Drug Delivery Systems with a “Tumor-Triggered” Targeting or Intracellular Drug Release Property Based on DePEGylation
Abstract
:1. Introduction
2. pH-Sensitive DePEGylation for “Tumor-Triggered” Targeting or Intracellular Drug Release
2.1. Benzoic Imine Bond-Based DePEGylation for “Tumor-Triggered” Targeting or Intracellular Drug Release
2.2. TACMAA-Based DePEGylation for “Tumor-Triggered” Targeting or Intracellular Drug Release
2.3. Ortho Ester-Based DePEGylation for “Tumor-Triggered” Targeting or Intracellular Drug Release
2.4. Other pH-Sensitive Linkages-Based DePEGylation for “Tumor-Triggered” Targeting or Intracellular Drug Release
3. Other Stimuli-Sensitive DePEGylation for “Tumor-Triggered” Targeting or Intracellular Drug Release
3.1. Enzyme-Sensitive “Tumor-Triggered” Targeting or Intracellular Drug Release
3.2. Redox-Sensitive “Tumor-Triggered” Targeting or Intracellular Drug Release
3.3. Light-Trigged DePEGylation for Targeting or Intracellular Drug Release
4. Conclusions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
- Sung, H.; Ferlay, J.; Siege, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021, 71, 209–249. [Google Scholar] [CrossRef]
- Allen, T.M.; Cullis, P.R. Drug Delivery Systems: Entering the Mainstream. Science 2004, 303, 1818–1822. [Google Scholar] [CrossRef] [Green Version]
- Shi, J.; Kantoff, P.W.; Wooster, R.; Farokhzad, O.C. Cancer nanomedicine: Progress, challenges and opportunities. Nat. Rev. Cancer 2017, 17, 20–37. [Google Scholar] [CrossRef] [PubMed]
- Chen, H.B.; Gu, Z.J.; An, H.W.; Chen, C.Y.; Chen, J.; Cui, R.; Chen, S.Q.; Chen, W.H.; Chen, X.S.; Chen, X.Y.; et al. Precise nanomedicine for intelligent therapy of cancer. Sci. China Chem. 2018, 61, 503–1552. [Google Scholar] [CrossRef]
- Mitchell, M.J.; Billingsley, M.M.; Haley, R.M.; Wechsler, M.E.; Peppas, N.A.; Langer, R. Engineering precision nanoparticles for drug delivery. Nat. Rev. Drug Discov. 2021, 20, 101–124. [Google Scholar] [CrossRef] [PubMed]
- Sun, Q.; Sun, X.; Ma, X.; Zhou, Z.; Jin, E.; Zhang, B.; Shen, Y.; Van Kirk, E.A.; Murdoch, W.J.; Lott, J.R.; et al. Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs. Adv. Mater. 2014, 26, 7615–7621. [Google Scholar] [CrossRef] [PubMed]
- Sun, Q.; Zhou, Z.; Qiu, N.; Shen, Y. Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization. Adv. Mater. 2017, 29, 1606628. [Google Scholar] [CrossRef] [PubMed]
- Nel, A.E.; Mädler, L.; Velegol, D.; Xia, T.; Hoek, E.M.V.; Somasundaran, P.; Klaessig, F.; Castranova, V.; Thompson, M. Understanding biophysicochemical interactions at the nano-bio interface. Nat. Mater. 2009, 8, 543–557. [Google Scholar] [CrossRef] [PubMed]
- de Almeida, M.S.; Susnik, E.; Drasler, B.; Taladriz-Blanco, P.; Petri-Fink, A.; Rothen-Rutishauser, B. Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine. Chem. Soc. Rev. 2021, 50, 5397–5434. [Google Scholar] [CrossRef] [PubMed]
- Fam, S.Y.; Chee, C.F.; Yong, C.Y.; Ho, K.L.; Mariatulqabtiah, A.R.; Tan, W.S. Stealth Coating of Nanoparticles in Drug-Delivery Systems. Nanomaterials 2020, 10, 787. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Liu, W.L.; Zou, M.Z.; Qin, S.Y.; Cheng, Y.J.; Ma, Y.H.; Sun, Y.X.; Zhang, X.Z. Recent advances of cell membrane-coated nanomaterials for biomedical applications. Adv. Funct. Mater. 2020, 30, 2003559. [Google Scholar] [CrossRef]
- Tang, L.; He, S.; Yin, Y.; Liu, H.; Hu, J.; Cheng, J.; Wang, W. Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment. Pharmaceutics 2021, 13, 1888. [Google Scholar] [CrossRef] [PubMed]
- Li, C.X.; Qi, Y.D.; Feng, J.; Zhang, X.Z. Cell-Based Bio-Hybrid Delivery System for Disease Treatments. Adv. NanoBiomed Res. 2021, 1, 2000052. [Google Scholar] [CrossRef]
- Le, Q.V.; Lee, J.; Lee, H.; Shim, G.; Oh, Y.K. Cell membrane-derived vesicles for delivery of therapeutic agents. Acta Pharm. Sin. B 2021, 11, 2096–2113. [Google Scholar] [CrossRef]
- Li, Y.; Raza, F.; Liu, Y.; Wei, Y.; Rong, R.; Zheng, M.; Yuan, W.; Su, J.; Qiu, M.; Li, Y.; et al. Clinical progress and advanced research of red blood cells based drug delivery system. Biomaterials 2021, 279, 121202. [Google Scholar] [CrossRef] [PubMed]
- Ren, L.; Qiu, L.; Huang, B.; Yin, J.; Li, Y.; Yang, X.; Chen, G. Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform. Nanomaterials 2021, 11, 2513. [Google Scholar] [CrossRef] [PubMed]
- He, X.; Cao, H.; Wang, H.; Tan, T.; Yu, H.; Zhang, P.; Yin, Q.; Zhang, Z.; Li, Y. Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy. Nano Lett. 2017, 17, 5546–5554. [Google Scholar] [CrossRef] [PubMed]
- Liang, T.; Zhang, R.; Liu, X.; Ding, Q.; Wu, S.; Li, C.; Lin, Y.; Ye, Y.; Zhong, Z.; Zhou, M. Recent Advances in Macrophage-Mediated Drug Delivery Systems. Int. J. Nanomed. 2021, 16, 2703–2714. [Google Scholar] [CrossRef]
- Zhang, Y.; Wang, Q.; Ma, T.; Zhu, D.; Liu, T.; Lv, F. Tumor targeted combination therapy mediated by functional macrophages under fluorescence imaging guidance. J. Control. Release 2020, 328, 127–140. [Google Scholar] [CrossRef] [PubMed]
- Chu, D.; Dong, X.; Shi, X.; Zhang, C.; Wang, Z. Neutrophil-Based Drug Delivery Systems. Adv. Mater. 2018, 30, 1706245. [Google Scholar] [CrossRef]
- Che, J.; Najer, A.; Blakney, A.K.; McKay, P.F.; Bellahcene, M.; Winter, C.W.; Sintou, A.; Tang, J.; Keane, T.J.; Schneider, M.D.; et al. Neutrophils Enable Local and Non-Invasive Liposome Delivery to Inflamed Skeletal Muscle and Ischemic Heart. Adv. Mater. 2020, 32, 2003598. [Google Scholar] [CrossRef] [PubMed]
- Zheng, D.W.; Fan, J.X.; Liu, X.H.; Dong, X.; Pan, P.; Xu, L.; Zhang, X.Z. A Simply Modified Lymphocyte for Systematic Cancer Therapy. Adv. Mater. 2018, 30, 1801622. [Google Scholar] [CrossRef] [PubMed]
- Li, M.; Li, S.; Zhou, H.; Tang, X.; Wu, Y.; Jiang, W.; Tian, Z.; Zhou, X.; Yang, X.; Wang, Y. Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy. Nat. Commun. 2020, 11, 1126. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ma, Y.; Zhang, Y.; Han, R.; Li, Y.; Zhai, Y.; Qian, Z.; Gu, Y.; Li, S. A cascade synergetic strategy induced by photothermal effect based on platelet exosome nanoparticles for tumor therapy. Biomaterials 2022, 282, 121384. [Google Scholar] [CrossRef] [PubMed]
- Jo, J.; Emi, T.; Tabata, Y. Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect. Pharmaceutics 2021, 13, 1724. [Google Scholar] [CrossRef]
- Herrmann, I.K.; Wood, M.J.A.; Fuhrmann, G. Extracellular vesicles as a next-generation drug delivery platform. Nat. Nanotechnol. 2021, 16, 748–759. [Google Scholar] [CrossRef]
- Liu, J.; Ye, Z.; Xiang, M.; Chang, B.; Cui, J.; Ji, T.; Zhao, L.; Li, Q.; Deng, Y.; Xu, L.; et al. Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance. Biomaterials 2019, 223, 119475. [Google Scholar] [CrossRef]
- Gangadaran, P.; Ahn, B.C. Extracellular Vesicle- and Extracellular Vesicle Mimetics-Based Drug Delivery Systems: New Perspectives, Challenges, and Clinical Developments. Pharmaceutics 2020, 12, 442. [Google Scholar] [CrossRef]
- Zhang, J.; Yuan, Z.F.; Wang, Y.; Chen, W.H.; Luo, G.F.; Cheng, S.X.; Zhuo, R.X.; Zhang, X.Z. Multifunctional envelope-type mesoporous silica nanoparticles for tumor-triggered targeting drug delivery. J. Am. Chem. Soc. 2013, 135, 5068–5073. [Google Scholar] [CrossRef] [PubMed]
- Du, X.J.; Wang, J.L.; Iqbal, S.; Li, H.J.; Cao, Z.T.; Wang, Y.C.; Du, J.Z.; Wang, J. The effect of surface charge on oral absorption of polymeric nanoparticles. Biomater. Sci. 2018, 6, 642–650. [Google Scholar] [CrossRef]
- Du, J.Z.; Li, H.J.; Wang, J. Tumor-acidity-cleavable maleic acid amide (TACMAA): A powerful tool for designing smart nanoparticles to overcome delivery barriers in cancer nanomedicine. Acc. Chem. Res. 2018, 51, 2848–2856. [Google Scholar] [CrossRef] [PubMed]
- Xu, X.; Duan, J.; Lan, Q.; Kuang, Y.; Liao, T.; Liu, Y.; Xu, Z.; Chen, J.; Jiang, B.; Li, C. A dual-sensitive poly(amino acid)/hollow mesoporous silica nanoparticle-based anticancer drug delivery system with a rapid charge-reversal property. J. Drug Deliv. Sci. Technol. 2021, 66, 102817. [Google Scholar] [CrossRef]
- Greenwald, R.B.; Choe, Y.H.; McGuire, J.; Conover, C.D. Effective drug delivery by PEGylated drug conjugates. Adv. Drug Delivery Rev. 2003, 55, 217–250. [Google Scholar] [CrossRef]
- Li, W.; Zhan, P.; De Clercq, E.; Lou, H.; Liu, X. Current drug research on PEGylation with small molecular agents. Prog. Polym. Sci. 2013, 38, 421–444. [Google Scholar] [CrossRef]
- Pasut, G.; Veronese, F.M. State of the art in PEGylation: The great versatility achieved after forty years of research. J. Control. Release 2012, 161, 461–472. [Google Scholar] [CrossRef]
- Kozma, G.T.; Shimizu, T.; Ishida, T.; Szebeni, J. Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals. Adv. Drug Deliv. Rev. 2020, 154–155, 163–175. [Google Scholar] [CrossRef]
- Suk, J.S.; Xu, Q.; Kim, N.; Hanes, J.; Ensign, L.M. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv. Drug Deliv. Rev. 2016, 99, 28–51. [Google Scholar] [CrossRef] [Green Version]
- Senevirathne, S.A.; Washington, K.E.; Biewera, M.C.; Stefan, M.C. PEG based anti-cancer drug conjugated prodrug micelles for the delivery of anti-cancer agents. J. Mater. Chem. B 2016, 4, 360–370. [Google Scholar] [CrossRef]
- Wang, K.; Luo, G.F.; Liu, Y.; Li, C.; Cheng, S.X.; Zhuo, R.X.; Zhang, X.Z. Redox-sensitive shell cross-linked PEG–polypeptide hybrid micelles for controlled drug release. Polym. Chem. 2012, 3, 1084–1090. [Google Scholar] [CrossRef]
- Wang, K.; Liu, Y.; Li, C.; Cheng, S.X.; Zhuo, R.X.; Zhang, X.Z. Cyclodextrin-Responsive Micelles Based on Poly(ethylene glycol)-Polypeptide Hybrid Copolymers as Drug Carriers. ACS Macro Lett. 2013, 2, 201–205. [Google Scholar] [CrossRef]
- Maruyama, K. Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects. Adv. Drug Deliv. Rev. 2011, 63, 161–169. [Google Scholar] [CrossRef] [PubMed]
- Kuang, Y.; Liu, J.; Liu, Z.; Zhuo, R. Cholesterol-based anionic long-circulating cisplatin liposomes with reduced renal toxicity. Biomaterials 2012, 33, 1596–1606. [Google Scholar] [CrossRef] [PubMed]
- Shimizu, T.; Awata, M.; Lila, A.S.A.; Yoshioka, C.; Kawaguchi, Y.; Ando, H.; Ishima, Y.; Ishida, T. Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes. J. Control. Release 2021, 329, 1046–1053. [Google Scholar] [CrossRef] [PubMed]
- Shi, J.; Yu, L.; Ding, J. PEG-based thermosensitive and biodegradable hydrogels. Acta Biomater. 2021, 128, 42–59. [Google Scholar] [CrossRef]
- Ilhami, F.B.; Yang, Y.T.; Lee, A.W.; Chiao, Y.H.; Chen, J.K.; Lee, D.J.; Lai, J.Y.; Cheng, C.C. Hydrogen Bond Strength-Mediated Self-Assembly of Supramolecular Nanogels for Selective and Effective Cancer Treatment. Biomacromolecules 2021, 22, 4446–4457. [Google Scholar] [CrossRef] [PubMed]
- Guo, H.; Li, F.; Qiu, H.; Xu, W.; Li, P.; Hou, Y.; Ding, J.; Chen, X. Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer. Research 2020, 2020, 8970135. [Google Scholar] [CrossRef] [PubMed]
- Wang, J.L.; Du, X.J.; Yang, J.X.; Shen, S.; Li, H.J.; Luo, Y.L.; Iqbal, S.; Xu, C.F.; Ye, X.D.; Cao, J.; et al. The effect of surface poly(ethylene glycol) length on in vivo drug delivery behaviors of polymeric nanoparticles. Biomaterials 2018, 182, 104–113. [Google Scholar] [CrossRef] [PubMed]
- Behl, A.; Parmar, V.S.; Malhotra, S.; Chhillar, A.K. Biodegradable diblock copolymeric PEG-PCL nanoparticles: Synthesis, characterization and applications as anticancer drug delivery agents. Polymer 2020, 207, 122901. [Google Scholar] [CrossRef]
- Liu, J.; Liu, X.; Yuan, Y.; Li, Q.; Chang, B.; Xu, L.; Cai, B.; Qi, C.; Li, C.; Jiang, X.; et al. Supramolecular Modular Approach toward Conveniently Constructing and Multifunctioning a pH/Redox Dual-Responsive Drug Delivery Nanoplatform for Improved Cancer Chemotherapy. ACS Appl. Mater. Interfaces 2018, 10, 26473–26484. [Google Scholar] [CrossRef]
- Wang, Y.; Quinsaat, J.E.Q.; Ono, T.; Maeki, M.; Tokeshi, M.; Isono, T.; Tajima, K.; Satoh, T.; Sato, S.; Miura, Y.; et al. Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol). Nat. Commun. 2020, 11, 6089. [Google Scholar] [CrossRef] [PubMed]
- Dai, J.; Dong, X.; Wang, Q.; Lou, X.; Xia, F.; Wang, S. PEG-Polymer Encapsulated Aggregation-Induced EmissionNanoparticles for Tumor Theranostics. Adv. Healthc. Mater. 2021, 10, 2101036. [Google Scholar] [CrossRef] [PubMed]
- Kunath, K.; von Harpe, A.; Petersen, H.; Fischer, D.; Voigt, K.; Kissel, T.; Bickel, U. The Structure of PEG-Modified Poly(Ethylene Imines) Influences Biodistribution and Pharmacokinetics of Their Complexes with NF-κB Decoy in Mice. Pharm. Res. 2002, 19, 810–817. [Google Scholar] [CrossRef] [PubMed]
- Xu, X.; Duan, J.; Liu, Y.; Kuang, Y.; Duan, J.; Liao, T.; Xu, Z.; Jiang, B.; Li, C. Multi-stimuli responsive hollow MnO2-based drug delivery system for magnetic resonance imaging and combined chemo-chemodynamic cancer therapy. Acta Biomater. 2021, 126, 445–462. [Google Scholar] [CrossRef] [PubMed]
- Chen, Z.; Liao, T.; Wan, L.; Kuang, Y.; Liu, C.; Duan, J.; Xu, X.; Xu, Z.; Jiang, B.; Li, C. Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery. Nano Res. 2021, 14, 4264–4273. [Google Scholar] [CrossRef]
- Wan, L.; Chen, Z.; Deng, Y.; Liao, T.; Kuang, Y.; Liu, J.; Duan, J.; Xu, Z.; Jiang, B.; Li, C. A novel intratumoral pH/redox-dual-responsive nanoplatform for cancer MR imaging and therapy. J. Colloid Interface Sci. 2020, 573, 263–277. [Google Scholar] [CrossRef] [PubMed]
- Kuang, Y.; Chen, H.; Chen, Z.; Wan, L.; Liu, J.; Xu, Z.; Chen, X.; Jiang, B.; Li, C. Poly(amino acid)/ZnO/mesoporous silica nanoparticle based complex drug delivery system with a charge-reversal property for cancer therapy. Colloids Surf. B Biointerfaces 2019, 181, 461–469. [Google Scholar] [CrossRef] [PubMed]
- Kong, L.; Campbell, F.; Kros, A. DePEGylation strategies to increase cancer nanomedicine efficacy. Nanoscale Horiz. 2019, 4, 378–387. [Google Scholar] [CrossRef] [Green Version]
- Quan, C.Y.; Chen, J.X.; Wang, H.Y.; Li, C.; Chang, C.; Zhang, X.Z.; Zhuo, R.X. Core-shell nanosized assemblies mediated by the α-β cyclodextrin dimer with a tumor-triggered targeting property. ACS Nano 2010, 4, 4211–4219. [Google Scholar] [CrossRef]
- Shi, L.; Zhang, J.; Zhao, M.; Tang, S.; Cheng, X.; Zhang, W.; Li, W.; Liu, X.; Peng, H.; Wang, Q. Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery. Nanoscale 2021, 13, 10748–10764. [Google Scholar] [CrossRef]
- Varlas, S.; Lawrenson, S.B.; Arkinstall, L.A.; O’Reilly, R.K.; Foster, J.C. Self-assembled nanostructures from amphiphilic block copolymers prepared via ring-opening metathesis polymerization (ROMP). Prog. Polym. Sci. 2020, 107, 101278. [Google Scholar] [CrossRef]
- Sethuraman, V.A.; Bae, Y.H. TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors. J. Control. Release 2007, 118, 216–224. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Liberti, M.V.; Locasale, J.W. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem. Sci. 2016, 41, 211–218. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Gu, J.; Cheng, W.P.; Liu, J.; Lo, S.Y.; Smith, D.; Qu, X.; Yang, Z. pH-triggered reversible “stealth” polycationic micelles. Biomacromolecules 2008, 9, 255–262. [Google Scholar] [CrossRef] [PubMed]
- Sun, W.; Davis, P.B. Reducible DNA nanoparticles enhance in vitro gene transfer via an extracellular mechanism. J. Control. Release 2010, 146, 118–127. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hu, X.; Wang, Y.; Peng, B. Chitosan-Capped Mesoporous Silica Nanoparticles as pH-Responsive Nanocarriers for Controlled Drug Release. Chem.-Asian J. 2014, 9, 319–327. [Google Scholar] [CrossRef] [PubMed]
- Gong, Y.H.; Li, C.; Yang, J.; Wang, H.Y.; Zhuo, R.X.; Zhang, X.Z. Photoresponsive “Smart Template” via Host-Guest Interaction for Reversible Cell Adhesion. Macromolecules 2011, 44, 7499–7502. [Google Scholar] [CrossRef]
- Wei, H.; Cheng, S.X.; Zhang, X.Z.; Zhuo, R.X. Thermo-sensitive polymeric micelles based on poly(N-isopropylacrylamide) as drug carriers. Prog. Polym. Sci. 2009, 34, 893–910. [Google Scholar] [CrossRef]
- Yang, S.; Zhu, F.; Wang, Q.; Liang, F.; Qu, X.; Gan, Z.; Yang, Z. Combinatorial targeting polymeric micelles for anti-tumor drug delivery. J. Mater. Chem. B 2015, 3, 4043–4051. [Google Scholar] [CrossRef]
- Xiao, D.; Jia, H.Z.; Zhang, J.; Liu, C.W.; Zhuo, R.X.; Zhang, X.Z. A Dual-Responsive Mesoporous Silica Nanoparticle for Tumor-Triggered Targeting Drug Delivery. Small 2014, 10, 591–598. [Google Scholar] [CrossRef]
- He, Q.; Shi, J. MSN anti-cancer nanomedicines: Chemotherapy enhancement, overcoming of drug resistance, and metastasis inhibition. Adv. Mater. 2014, 26, 391–411. [Google Scholar] [CrossRef]
- Kuang, Y.; Zhai, J.; Xiao, Q.; Zhao, S.; Li, C. Polysaccharide/mesoporous silica nanoparticle-based drug delivery systems: A review. Int. J. Biol. Macromol. 2021, 193, 457–473. [Google Scholar] [CrossRef] [PubMed]
- Zhang, M.; Liu, J.; Kuang, Y.; Li, Q.; Chen, H.; Ye, H.; Guo, L.; Xu, Y.; Chen, X.; Li, C.; et al. “Stealthy’’ chitosan/mesoporous silica nanoparticle based complex system for tumor–triggered intracellular drug release. J. Mater. Chem. B 2016, 4, 3387–3397. [Google Scholar] [CrossRef]
- Liao, T.; Liu, C.; Ren, J.; Chen, H.; Kuang, Y.; Jiang, B.; Chen, J.; Sun, Z.; Li, C. A chitosan/mesoporous silica nanoparticle-based anticancer drug delivery system with a “tumor-triggered targeting” property. Int. J. Biol. Macromol. 2021, 183, 2017–2029. [Google Scholar] [CrossRef]
- Shafabakhsh, R.; Yousefi, B.; Asemi, Z.; Nikfar, B.; Mansournia, M.A.; Hallajzadeh, J. Chitosan: A compound for drug delivery system in gastric cancer—A review. Carbohyd. Polym. 2020, 242, 116403. [Google Scholar] [CrossRef]
- Sogias, I.A.; Williams, A.C.; Khutoryanskiy, V.V. Why is Chitosan Mucoadhesive? Biomacromolecules 2008, 9, 1837–1842. [Google Scholar] [CrossRef] [PubMed]
- Mo, R.; Gu, Z. Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery. Mater. Today 2016, 19, 274–283. [Google Scholar] [CrossRef]
- Zheng, D.W.; Chen, J.L.; Zhu, J.Y.; Rong, L.; Li, B.; Lei, Q.; Fan, J.X.; Zou, M.Z.; Li, C.; Cheng, S.X.; et al. Highly Integrated Nano-Platform for Breaking the Barrier between Chemotherapy and Immunotherapy. Nano Lett. 2016, 16, 4341–4347. [Google Scholar] [CrossRef] [PubMed]
- Wang, X.G.; Dong, Z.Y.; Cheng, H.; Wan, S.S.; Chen, W.H.; Zou, M.Z.; Huo, J.W.; Deng, H.X.; Zhang, X.Z. A multifunctional metal-organic framework based tumor targeting drug delivery system for cancer therapy. Nanoscale 2015, 7, 16061–16070. [Google Scholar] [CrossRef] [PubMed]
- Wang, C.; Chen, X.; Yao, X.; Chen, L.; Chen, X. Dual acid-responsive supramolecular nanoparticles as new anticancer drug delivery systems. Biomater. Sci. 2016, 4, 104–114. [Google Scholar] [CrossRef]
- Wang, C.; Wang, J.; Chen, X.; Zheng, X.; Xie, Z.; Chen, L.; Chen, X. Phenylboronic Acid-Cross-Linked Nanoparticles with Improved Stability as Dual Acid-Responsive Drug Carriers. Macromol. Biosci. 2017, 17, 1600227. [Google Scholar] [CrossRef]
- Chen, H.; Chen, Z.; Kuang, Y.; Li, S.; Zhang, M.; Liu, J.; Sun, Z.; Jiang, B.; Chen, X.; Li, C. Stepwise-acid-active organic/inorganic hybrid drug delivery system for cancer therapy. Colloids Surf. B Biointerfaces 2018, 167, 407–414. [Google Scholar] [CrossRef]
- Chen, H.; Kuang, Y.; Liu, R.; Chen, Z.; Jiang, B.; Sun, Z.; Chen, X.; Li, C. Dual-pH-sensitive mesoporous silica nanoparticle-based drug delivery system for tumor-triggered intracellular drug release. J. Mater. Sci. 2018, 53, 10653–10665. [Google Scholar] [CrossRef]
- Hung, Y.N.; Liu, Y.L.; Chou, Y.H.; Hu, S.H.; Cheng, B.; Chiang, W.H. Promoted cellular uptake and intracellular cargo release of ICG/DOX-carrying hybrid polymeric nanoassemblies upon acidity-activated PEG detachment to enhance cancer photothermal/chemo combination therapy. Eur. Polym. J. 2022, 163, 110944. [Google Scholar] [CrossRef]
- Luo, G.F.; Chen, W.H.; Liu, Y.; Lei, Q.; Zhuo, R.X.; Zhang, X.Z. Multifunctional Enveloped Mesoporous Silica Nanoparticles for Subcellular Co-delivery of Drug and Therapeutic Peptide. Sci. Rep. 2014, 4, 6064. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Zhao, C.; Shao, L.; Lu, J.; Deng, X.; Wu, Y. Tumor Acidity-Induced Sheddable Polyethylenimine-Poly(trimethylene carbonate)/DNA/Polyethylene Glycol-2,3-Dimethylmaleicanhydride Ternary Complex for Efficient and Safe Gene Delivery. ACS Appl. Mater. Interfaces 2016, 8, 6400–6410. [Google Scholar] [CrossRef]
- Du, J.Z.; Sun, T.M.; Song, W.J.; Wu, J.; Wang, J. A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery. Angew. Chem. 2010, 49, 3621–3626. [Google Scholar] [CrossRef]
- Sun, C.Y.; Liu, Y.; Du, J.Z.; Cao, Z.T.; Xu, C.F.; Wang, J. Facile Generation of Tumor-pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery. Angew. Chem. 2016, 128, 1022–1026. [Google Scholar] [CrossRef]
- Zhou, Y.J.; Wan, W.J.; Tong, Y.; Chen, M.T.; Wang, D.D.; Wang, Y.; You, B.G.; Liu, Y.; Zhang, X.N. Stimuli-responsive nanoparticles for the codelivery of chemotherapeutic agents doxorubicin and siPD-L1 to enhance the antitumor effect. J. Biomed. Mater. Res. 2020, 108, 1710–1724. [Google Scholar] [CrossRef]
- Wang, M.; Ruan, L.; Zheng, T.; Wang, D.; Zhou, M.; Lu, H.; Gao, J.; Chen, J.; Hu, Y. A surface convertible nanoplatform with enhanced mitochondrial targeting for tumor photothermal therapy. Colloids Surf. B Biointerfaces 2020, 189, 110854. [Google Scholar] [CrossRef]
- Wang, X.; Li, M.; Hou, Y.; Li, Y.; Yao, X.; Xue, C.; Fei, Y.; Xiang, Y.; Cai, K.; Zhao, Y.; et al. Tumor-Microenvironment-Activated In Situ Self-Assembly of Sequentially Responsive Biopolymer for Targeted Photodynamic Therapy. Adv. Funct. Mater. 2020, 30, 2000229. [Google Scholar] [CrossRef]
- Zhong, W.; Pang, L.; Feng, H.; Dong, H.; Wang, S.; Cong, H.; Shen, Y.; Bing, Y. Recent advantage of hyaluronic acid for anti-cancer application: A review of “3S” transition approach. Carbohydr. Polym. 2020, 238, 116204. [Google Scholar] [CrossRef] [PubMed]
- Shao, S.; Hu, Q.; Wu, W.; Wang, M.; Huang, J.; Zhao, X.; Tang, G.; Liang, T. Tumor-triggered personalized microRNA cocktail therapy for hepatocellular carcinoma. Biomater. Sci. 2020, 8, 6579–6591. [Google Scholar] [CrossRef] [PubMed]
- Ji, R.; Cheng, J.; Yang, T.; Song, C.C.; Li, L.; Du, F.S.; Li, Z.C. Shell-Sheddable, pH-Sensitive Supramolecular Nanoparticles Based on Ortho Ester-Modified Cyclodextrin and Adamantyl PEG. Biomacromolecules 2014, 15, 3531–3539. [Google Scholar] [CrossRef] [PubMed]
- Yan, G.; Zhang, P.; Wang, J.; Wang, X.; Tang, R. Dynamic micelles with detachable PEGylation at tumoral extracellular pH for enhanced chemotherapy. Asian J. Pharm. Sci. 2020, 15, 728–738. [Google Scholar] [CrossRef] [PubMed]
- Yan, G.; Huang, Y.; Li, D.; Xu, Y.; Wang, J.; Wang, X.; Tang, R. Sequentially dynamic polymeric micelles with detachable PEGylation for enhanced chemotherapeutic efficacy. Eur. J. Pharm. Biopharm. 2019, 145, 54–64. [Google Scholar] [CrossRef]
- Wang, X.; Zheng, Y.; Xue, Y.B.; Wu, Y.; Liu, Y.; Cheng, X.; Tang, R. pH-sensitive and tumor-targeting nanogels based on ortho ester-modified PEG for improving the in vivo anti-tumor efficiency of doxorubicin. Colloid. Surf. B Biointerfaces 2021, 207, 112024. [Google Scholar] [CrossRef]
- Xu, J.; Hu, T.; Zhang, M.; Feng, P.; Wang, X.; Cheng, X.; Tang, R. A sequentially responsive nanogel via Pt(IV) crosslinking for overcoming GSH-mediated platinum resistance. J. Colloid Interf. Sci. 2021, 601, 85–97. [Google Scholar] [CrossRef]
- Yang, L.; Yan, G.; Wang, S.; Xu, J.; Fang, Q.; Xue, Y.; Yang, L.; Xu, X.; Tang, R. Dynamic precise dual-drug-backboned nano-prodrugs for selective chemotherapy. Acta Biomater. 2021, 129, 209–219. [Google Scholar] [CrossRef]
- Lv, X.; Wang, S.; Dong, Y.; Zhang, Y.; Wang, X.; Yan, G.; Wang, J.; Tang, R. Dynamic methotrexate nano-prodrugs with detachable PEGylation for highly selective synergistic chemotherapy. Colloid. Surf. B Biointerfaces 2021, 201, 111619. [Google Scholar] [CrossRef] [PubMed]
- Zhang, M.; Liu, J.; Kuang, Y.; Li, Q.; Zheng, D.W.; Song, Q.; Chen, H.; Chen, X.; Xu, Y.; Li, C.; et al. Ingenious pH-sensitive dextran/mesoporous silica nanoparticles based drug delivery systems for controlled intracellular drug release. Int. J. Biol. Macromol. 2017, 98, 691–700. [Google Scholar] [CrossRef]
- Wang, S.; Wang, H.; Liu, Z.; Wang, L.; Wang, X.; Su, L.; Chang, J. Smart pH- and reduction-dual-responsive folate-PEG-coated polymeric lipid vesicles for tumor-triggered targeted drug delivery. Nanoscale 2014, 6, 7635–7642. [Google Scholar] [CrossRef] [PubMed]
- Sun, L.; Wei, H.; Zhang, X.; Meng, C.; Kang, G.; Ma, W.; Ma, L.; Wang, B.; Yu, C. Synthesis of polymeric micelles with dual-functional sheddable PEG stealth for enhanced tumor-targeted drug delivery. Polym. Chem. 2020, 11, 4469–4476. [Google Scholar] [CrossRef]
- Kanamala, M.; Palmer, B.D.; Wilson, W.R.; Wu, Z. Characterization of a smart pH-cleavable PEG polymer towards the development of dual pH-sensitive liposomes. Int. J. Pharmaceut. 2018, 548, 288–296. [Google Scholar] [CrossRef]
- Cheng, Y.; Zou, T.; Dai, M.; He, X.Y.; Peng, N.; Wu, K.; Wang, X.Q.; Liao, C.Y.; Liu, Y. Doxorubicin loaded tumor-triggered targeting ammonium bicarbonate liposomes for tumor-specific drug delivery. Colloid. Surf. B Biointerfaces 2019, 178, 263–268. [Google Scholar] [CrossRef] [PubMed]
- Domiński, A.; Domińska, M.; Skonieczna, M.; Pastuch-Gawołek, G.; Kurcok, P. Shell-Sheddable Micelles Based on Poly(ethylene glycol)-hydrazone-poly[R,S]-3-hydroxybutyrate Copolymer Loaded with 8-Hydroxyquinoline Glycoconjugates as a Dual Tumor-Targeting Drug Delivery System. Pharmaceutics 2022, 14, 290. [Google Scholar] [CrossRef] [PubMed]
- Kim, H.K.; Van den Bossche, J.; Hyun, S.H.; Thompson, D.H. Acid-Triggered Release via dePEGylation of Fusogenic Liposomes Mediated by Heterobifunctional Phenyl-Substituted Vinyl Ethers with Tunable pH-Sensitivity. Bioconjugate Chem. 2012, 23, 2071–2077. [Google Scholar] [CrossRef] [Green Version]
- Kim, H.K.; Thompson, D.H.; Jang, H.S.; Chung, Y.J.; van den Bossche, J. pH-Responsive Biodegradable Assemblies Containing Tunable Phenyl-Substituted Vinyl Ethers for Use as Efficient Gene Delivery Vehicles. ACS Appl. Mater. Interfaces 2013, 5, 5648–5658. [Google Scholar] [CrossRef] [Green Version]
- Luo, Q.; Shi, W.; Wang, P.; Zhang, Y.; Meng, J.; Zhang, L. Tumor Microenvironment-Responsive Shell/Core Composite Nanoparticles for Enhanced Stability and Antitumor Efficiency Based on a pH-Triggered Charge-Reversal Mechanism. Pharmaceutics 2021, 13, 895. [Google Scholar] [CrossRef]
- Tseng, W.C.; Su, L.Y.; Fang, T.Y. pH responsive PEGylation through metal affinity for gene delivery mediated by histidine-grafted polyethylenimine. Biomed. Mater. Res. Part B Appl. Biomater. 2013, 101B, 375–386. [Google Scholar] [CrossRef]
- Kapalatiya, H.; Madav, Y.; Tambe, V.S.; Wairkar, S. Enzyme-responsive smart nanocarriers for targeted chemotherapy: An overview. Drug Deliv. Transl. Res. 2022, 12, 1293–1305. [Google Scholar] [CrossRef]
- Mondal, S.; Adhikari, N.; Banerjee, S.; Amin, S.A.; Jha, T. Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview. Eur. J. Med. Chem. 2020, 194, 112260. [Google Scholar] [CrossRef] [PubMed]
- Eliasen, R.; Andresen, T.L.; Larsen, J.B. Quantifying the heterogeneity of enzymatic dePEGylation of liposomal nanocarrier systems. Eur. J. Pharm. Biopharm. 2022, 171, 80–89. [Google Scholar] [CrossRef] [PubMed]
- Lei, Q.; Qiu, W.X.; Hu, J.J.; Cao, P.X.; Zhu, C.H.; Cheng, H.; Zhang, X.Z. Multifunctional Mesoporous Silica Nanoparticles with Thermal-Responsive Gatekeeper for NIR Light-Triggered Chemo/Photothermal-Therapy. Small 2016, 12, 4286–4298. [Google Scholar] [CrossRef] [PubMed]
- Ke, W.; Li, J.; Zhao, K.; Zha, Z.; Han, Y.; Wang, Y.; Yin, W.; Zhang, P.; Ge, Z. Modular Design and Facile Synthesis of Enzyme-Responsive PeptideLinked Block Copolymers for Efficient Delivery of Doxorubicin. Biomacromolecules 2016, 17, 3268–3276. [Google Scholar] [CrossRef]
- Ke, W.; Zha, Z.; Mukerabigwi, J.F.; Chen, W.; Wang, Y.; He, C.; Ge, Z. Matrix Metalloproteinase-Responsive Multifunctional Peptide-Linked Amphiphilic Block Copolymers for Intelligent Systemic Anticancer Drug Delivery. Bioconjugate Chem. 2017, 28, 2190–2198. [Google Scholar] [CrossRef]
- Li, J.; Xiao, S.; Xu, Y.; Zuo, S.; Zha, Z.; Ke, W.; He, C.; Ge, Z. Smart Asymmetric Vesicles with Triggered Availability of Inner Cell-Penetrating Shells for Specific Intracellular Drug Delivery. ACS Appl. Mater. Interfaces 2017, 9, 17727–17735. [Google Scholar] [CrossRef]
- Wang, J.; Wang, H.; Cui, H.; Sun, P.; Yang, X.; Chen, Q. Circumvent PEGylation dilemma by implementing matrix metalloproteinase-responsive chemistry for promoted tumor gene therapy. Chin. Chem. Lett. 2020, 31, 3143–3148. [Google Scholar] [CrossRef]
- Gordon, M.R.; Zhao, B.; Anson, F.; Fernandez, A.; Singh, K.; Homyak, C.; Canakci, M.; Vachet, R.W.; Thayumanavan, S. Matrix Metalloproteinase-9-Responsive Nanogels for Proximal Surface Conversion and Activated Cellular Uptake. Biomacromolecules 2018, 19, 860–871. [Google Scholar] [CrossRef] [PubMed]
- Li, J.; Ge, Z.; Toh, K.; Liu, X.; Dirisala, A.; Ke, W.; Wen, P.; Zhou, H.; Wang, Z.; Xiao, S.; et al. Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer. Adv. Mater. 2021, 33, 2105254. [Google Scholar] [CrossRef] [PubMed]
- Bruun, J.; Larsen, T.B.; Jølck, R.I.; Eliasen, R.; Holm, R.; Gjetting, T.; Andresen, T.L. Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood-brain barrier and glioma cells. Int. J. Nanomed. 2015, 10, 5995–6008. [Google Scholar] [CrossRef] [Green Version]
- Hsua, P.H.; Almutairi, A. Recent progress of redox-responsive polymeric nanomaterials for controlled release. J. Mater. Chem. B 2021, 9, 2179–2188. [Google Scholar] [CrossRef] [PubMed]
- Mollazadeh, S.; Mackiewicz, M.; Yazdimamaghani, M. Recent advances in the redox-responsive drug delivery nanoplatforms: A chemical structure and physical property perspective. Mater. Sci. Eng. C 2021, 118, 111536. [Google Scholar] [CrossRef] [PubMed]
- Xu, Z.; Chen, L.; Zhang, Z.; Gu, W.; Li, Y. “Intelligent” nanoassembly for gene delivery: In vitro transfection and the possible mechanism. Int. J. Pharm. 2010, 383, 271–276. [Google Scholar] [CrossRef] [PubMed]
- Wang, K.; Liu, Y.; Yi, W.J.; Li, C.; Li, Y.Y.; Zhuo, R.X.; Zhang, X.Z. Novel shell-cross-linked micelles with detachable PEG corona for glutathione-mediated intracellular drug delivery. Soft Matter 2013, 9, 692–699. [Google Scholar] [CrossRef]
- Ai, X.; Sun, J.; Zhong, L.; Wu, C.; Niu, H.; Xu, T.; Lian, H.; Han, X.; Ren, G.; Ding, W.; et al. Star-Shape Redox-Responsive PEG-Sheddable Copolymer of Disulfide-Linked Polyethylene Glycol-Lysine-di-Tocopherol Succinate for Tumor-Triggering Intracellular Doxorubicin Rapid Release: Head-to-Head Comparison. Macromol. Biosci. 2014, 14, 1415–1428. [Google Scholar] [CrossRef]
- Hu, Q.; Wang, K.; Sun, X.; Li, Y.; Fu, Q.; Liang, T.; Tang, G. A redox-sensitive, oligopeptide-guided, self-assembling, and efficiency-enhanced (ROSE) system for functional delivery of microRNA therapeutics for treatment of hepatocellular carcinoma. Biomaterials 2016, 104, 192–200. [Google Scholar] [CrossRef]
- Sun, C.; Tan, Y.; Xu, H. From Selenite to Diselenide-Containing Drug Delivery Systems. ACS Mater. Lett. 2020, 2, 1173–1177. [Google Scholar] [CrossRef]
- Choi, Y.S.; Huh, K.M.; Shim, M.S.; Park, I.S.; Cho, Y.Y.; Lee, J.Y.; Lee, H.S.; Kang, H.C. Disrupting the Redox Balance with a Diselenide Drug Delivery System: Synergistic or Antagonistic? Adv. Funct. Mater. 2021, 31, 2007275. [Google Scholar] [CrossRef]
- Li, W.; Zhang, P.; Zheng, K.; Hu, Q.; Wang, Y. Redox-triggered intracellular dePEGylation based on diselenide-linked polycations for DNA delivery. J. Mater. Chem. B 2013, 1, 6418–6426. [Google Scholar] [CrossRef]
- Kumari, R.; Sunil, D.; Ningthoujam, R.S. Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: An up-to-date review. J. Control. Release 2020, 319, 135–156. [Google Scholar] [CrossRef]
- Li, J.; Meng, X.; Deng, J.; Lu, D.; Zhang, X.; Chen, Y.; Zhu, J.; Fan, A.; Ding, D.; Kong, D.; et al. Multifunctional Micelles Dually Responsive to Hypoxia and Singlet Oxygen: Enhanced Photodynamic Therapy via Interactively Triggered Photosensitizer Delivery. ACS Appl. Mater. Interfaces 2018, 10, 17117–17128. [Google Scholar] [CrossRef]
- Im, S.; Lee, J.; Park, D.; Park, A.; Kim, Y.M.; Kim, W.J. Hypoxia-Triggered Transforming Immunomodulator for Cancer Immunotherapy via Photodynamically Enhanced Antigen Presentation of Dendritic Cell. ACS Nano 2019, 13, 476–488. [Google Scholar] [CrossRef] [PubMed]
- Zhou, B.; Guo, Z.; Lin, Z.; Zhang, L.; Jiang, B.P.; Shen, X.C. Recent insights into near-infrared light-responsive carbon dots for bioimaging and cancer phototherapy. Inorg. Chem. Front. 2019, 6, 1116–1128. [Google Scholar] [CrossRef]
- Liang, C.; Xu, L.; Song, G.; Liu, Z. Emerging nanomedicine approaches fighting tumor metastasis: Animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy. Chem. Soc. Rev. 2016, 45, 6250–6269. [Google Scholar] [CrossRef] [PubMed]
- Tang, Y.; Wang, G. NIR light-responsive nanocarriers for controlled release. J. Photochem. Photobiol. C Photochem. Rev. 2021, 47, 100420. [Google Scholar] [CrossRef]
- Li, W.; Wang, Y.; Chen, L.; Huang, Z.; Hu, Q.; Ji, J. Light-regulated host-guest interaction as a new strategy for intracellular PEG-detachable polyplexes to facilitate nuclear entry. Chem. Commun. 2012, 48, 10126–10128. [Google Scholar] [CrossRef]
- Xiao, W.; Chen, W.H.; Xu, X.D.; Li, C.; Zhang, J.; Zhuo, R.X.; Zhang, X.Z. Design of a Cellular-Uptake-Shielding “Plug and Play” Template for Photo Controllable Drug Release. Adv. Mater. 2011, 23, 3526–3530. [Google Scholar] [CrossRef]
- Li, Y.; Lv, W.; Wang, L.; Zhang, Y.; Yang, L.; Wang, T.; Zhu, L.; Wang, Y.; Wang, W. Photo-triggered nucleus targeting for cancer drug delivery. Nano Res. 2021, 14, 2630–2636. [Google Scholar] [CrossRef]
- Deng, X.; Zheng, N.; Song, Z.; Yin, L.; Cheng, J. Trigger-responsive, fast-degradable poly(β-amino ester)s for enhanced DNA unpackaging and reduced toxicity. Biomaterials 2014, 35, 5006–5015. [Google Scholar] [CrossRef] [Green Version]
- Zhou, M.; Huang, H.; Wang, D.; Lu, H.; Chen, J.; Chai, Z.; Yao, S.Q.; Hu, Y. Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration. Nano Lett. 2019, 19, 3671–3675. [Google Scholar] [CrossRef]
- Kong, L.; Chen, Q.; Campbell, F.; Snaar-Jagalska, E.; Kros, A. Light-Triggered Cancer Cell Specific Targeting and Liposomal Drug Delivery in a Zebrafish Xenograft Model. Adv. Healthc. Mater. 2020, 9, 1901489. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Zhu, Y.; Chen, C.; Cao, Z.; Shen, S.; Li, L.; Li, D.; Wang, J.; Yang, X. On-demand PEGylation and dePEGylation of PLA-based nanocarriers via amphiphilic mPEG-TK-Ce6 for nanoenabled cancer chemotherapy. Theranostics 2019, 9, 8312–8320. [Google Scholar] [CrossRef] [PubMed]
- Chatterjee, S.; Hui, P.C. Review of Applications and Future Prospects of Stimuli-Responsive Hydrogel Based on Thermo-Responsive Biopolymers in Drug Delivery Systems. Polymers 2021, 13, 2086. [Google Scholar] [CrossRef] [PubMed]
- Atanase, L.I. Micellar Drug Delivery Systems Based on Natural Biopolymers. Polymers 2021, 13, 477. [Google Scholar] [CrossRef]
- Abdelhamid, H.N.; Mathew, A.P. Cellulose-Based Nanomaterials Advance Biomedicine: A Review. Int. J. Mol. Sci. 2022, 23, 5405. [Google Scholar] [CrossRef]
Stimuli of DePEGylation | Dynamic Interaction | Targeting Mode | Stimuli of Cargo Release | Carrier | Cargo | Biology Experiment | Ref. |
---|---|---|---|---|---|---|---|
pH | Benzoic imine | Positive charge | N.A. | Micelles | N.A. | In vitro | [63] |
GSH | MSNs | DOX | In vitro | [72] | |||
pH | NPs | DOX | In vitro | [79,80] | |||
MSNs | DOX | In vitro | [81,82] | ||||
Polymeric vehicle | ICG/DOX | In vitro | [83] | ||||
Targeting peptide | Temperature | Micelles | DOX | In vitro | [58] | ||
GSH | MSNs | DOX | In vitro | [69] | |||
MOFs | DOX | In vitro/in vivo | [78] | ||||
Positive charge/ targeting peptide | pH | MSNs | DOX | In vitro/in vivo | [73] | ||
TACMAA | Positive charge | GSH | MSNs | TPT | In vitro | [84] | |
NPs | siRNA/DOX | In vitro/in vivo | [88] | ||||
pH | Micelles | DTXL | In vitro/in vivo | [87] | |||
NPs | DNA | In vitro/in vivo | [85] | ||||
miRNA | In vitro/in vivo | [92] | |||||
HA | GSH | Micelles | ZnPc | In vitro/in vivo | [90] | ||
Mitochondrial targeting | N.A. | NPs | Carbon nanotubes | In vitro | [89] | ||
Ortho ester | Positive charge | pH | Micelles | DOX | In vitro/in vivo | [94,95] | |
PBA | GSH | Nanogels | Pt(IV) | In vitro/in vivo | [96] | ||
H2O2 | Nanogels | Pt(IV) | In vitro/in vivo | [97] | |||
N.A. | pH | Micelles | MTX/DOX | In vitro/in vivo | [98] | ||
pH/GSH | Micelles | Pt(IV) | In vitro/in vivo | [99] | |||
Hydrazone | FA | GSH | Polymeric lipid vesicles | DOX | In vitro | [101] | |
Micelles | DOX | In vitro | [102] | ||||
Imine | FA | Temperature/pH | Liposomes | DOX | In vitro | [104] | |
PIVE | Positive charge | pH | Liposomes | Calcein | In vitro | [106] | |
DNA | In vitro | [107] | |||||
Electrostatic interaction | Positive charge | N.A. | NPs | DSF | In vitro/in vivo | [108] | |
Coordination interaction | Positive charge | pH | NPs | DNA | In vitro | [109] | |
Enzyme | MMP-sensitive peptide | Targeting peptide | NIR | MSNs | ICG/DOX | In vitro/in vivo | [113] |
pH/esterase | Micelles | DOX | In vitro | [114] | |||
MMP-2 | Micelles | PTX | In vitro/in vivo | [115] | |||
Positive charge | MMP-2 | Vesicles | Calcein/PTX | In vitro | [116] | ||
NPs | DNA | In vitro/in vivo | [117] | ||||
Polymersomes | Colchicine/marimastat | In vitro/in vivo | [119] | ||||
GSH | Nanogels | DiI | In vitro | [118] | |||
Angiopep | pH | NPs | siRNA | In vitro | [120] | ||
Redox | Disulfide bond | N.A. | GSH | NPs | DNA | In vitro | [123] |
Micelles | DOX | In vitro | [124,125] | ||||
NPs | miRNA | In vitro/in vivo | [126] | ||||
Diselenide bond | N.A. | GSH | NPs | DNA | In vitro | [129] | |
Azo bond | Positive charge | NIR | Micelles | Ce6 | In vitro/in vivo | [131] | |
MSNs | CpG/Ce6 | In vitro/in vivo | [132] | ||||
Light | Host–guest interaction | N.A. | N.A. | NPs | DNA | In vitro | [136] |
DEACM bond | Targeting peptide | N.A. | NPs | Cb | In vitro | [138] | |
Nbz bond | Targeting peptide | pH/NIR | NPs | DOX | In vitro/in vivo | [140] | |
Targeting peptide/FA | N.A. | Liposomes | Propidium iodide | In vitro/in vivo | [141] | ||
TK bond | N.A. | GSH | NPs | Pt(IV) | In vitro/in vivo | [142] |
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Ren, Z.; Liao, T.; Li, C.; Kuang, Y. Drug Delivery Systems with a “Tumor-Triggered” Targeting or Intracellular Drug Release Property Based on DePEGylation. Materials 2022, 15, 5290. https://doi.org/10.3390/ma15155290
Ren Z, Liao T, Li C, Kuang Y. Drug Delivery Systems with a “Tumor-Triggered” Targeting or Intracellular Drug Release Property Based on DePEGylation. Materials. 2022; 15(15):5290. https://doi.org/10.3390/ma15155290
Chicago/Turabian StyleRen, Zhe, Tao Liao, Cao Li, and Ying Kuang. 2022. "Drug Delivery Systems with a “Tumor-Triggered” Targeting or Intracellular Drug Release Property Based on DePEGylation" Materials 15, no. 15: 5290. https://doi.org/10.3390/ma15155290