An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Mounthwash Formulation
2.3. Sample Size and Randomization
2.4. Clinical Procedures
2.5. Clinical and Patient-Reported Outcomes
2.6. Statistical Analysis
3. Results
3.1. Population
3.2. Clinical and Salivary Outcomes
3.3. Adverse Effects and Patient-Centered Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Test Group (n = 32) | Control Group (n = 32) | p Value Test vs. Control |
---|---|---|---|
Age (years) | 3.9 ± 0.9 | 3.7 ± 1.0 | 0.426 |
Range | 2–5 | 2–5 | - |
Females | 15 (46.9) | 17 (53.1) | 0.617 |
Variables | Group | Baseline | 2 Weeks | Δ0–2 weeks | 4 Weeks | Δ0–4 weeks |
---|---|---|---|---|---|---|
FMPS (%) | Test | 60.9 ± 9.5 a | 22.9 ± 6.0 b | 38.0 ± 9.5 | 9.8 ± 2.9 b | 51.1 ± 10.5 |
Control | 57.6 ± 10.7 a | 38.5 ± 11.4 b | 19.1 ± 10.5 | 25.8 ± 7.3 b | 31.8 ± 12.4 | |
Difference between groups | NS | <0.01 | <0.001 | |||
FMBS (%) | Test | 27.8 ± 10.5 a | 9.6 ± 4.1 b | 20.2 ± 10.3 | 3.9 ± 2.7 b | 25.9 ± 10.6 |
Control | 31.6 ± 9.8 a | 19.8 ± 8.7 b | 11.8 ± 9.5 | 12.2 ± 4.4 b | 19.4 ± 8.9 | |
Difference between groups | NS | <0.001 | <0.001 |
Variable | Time | Test Group | Control Group | p Value | |||||
---|---|---|---|---|---|---|---|---|---|
2–3 Years (n = 11) A | 4–5 Years (n = 21) B | 2–3 Years (n = 13) C | 4–5 Years (n = 19) D | A vs. B | A vs. C | B vs. D | C vs. D | ||
FMPS (%) | Baseline a (T0) | 60.8 ± 9.0 | 61.0 ± 9.9 | 57.6 ± 12.1 | 58.7 ± 10.0 | NS | NS | NS | NS |
2 weeks b (T1) | 23.2 ± 5.8 | 22.8 ± 6.2 | 41.6 ± 12.5 | 36.5 ± 10.4 | NS | <0.001 | <0.001 | NS | |
p T0 vs. T1 | <0.001 | <0.001 | 0.002 | 0.001 | |||||
4 weeks b (T2) | 8.8 ± 3.2 | 10.2 ± 2.6 | 28.0 ± 5.2 | 24.4 ± 8.2 | NS | <0.001 | <0.001 | NS | |
p T1 vs. T2 | 0.001 | <0.001 | 0.005 | 0.006 | |||||
FMBS (%) | Baseline a (T0) | 32.3 ± 9.3 | 28.5 ± 11.1 | 32.4 ± 10.3 | 31.1 ± 9.7 | NS | NS | NS | NS |
2 weeks b (T1) | 9.4 ± 3.0 | 9.7 ± 4.5 | 21.8 ± 9.5 | 18.5 ± 8.1 | NS | <0.001 | 0.001 | NS | |
p T0 vs. T1 | < 0.001 | 0.002 | NS | 0.006 | |||||
4 weeks b (T2) | 4.8 ± 3.7 | 3.5 ± 1.8 | 12.7 ± 4.1 | 11.9 ± 4.6 | NS | <0.001 | <0.001 | NS | |
p T1 vs. T2 | NS | 0.001 | 0.018 | 0.002 |
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Berta, G.N.; Romano, F.; Vallone, R.; Abbadessa, G.; Di Scipio, F.; Defabianis, P. An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach. Materials 2021, 14, 3801. https://doi.org/10.3390/ma14143801
Berta GN, Romano F, Vallone R, Abbadessa G, Di Scipio F, Defabianis P. An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach. Materials. 2021; 14(14):3801. https://doi.org/10.3390/ma14143801
Chicago/Turabian StyleBerta, Giovanni Nicolao, Federica Romano, Roberta Vallone, Giuliana Abbadessa, Federica Di Scipio, and Patrizia Defabianis. 2021. "An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach" Materials 14, no. 14: 3801. https://doi.org/10.3390/ma14143801