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Article

Associations of Waist Circumference, Socioeconomic, Environmental, and Behavioral Factors with Chronic Kidney Disease in Normal Weight, Overweight, and Obese People

by
Tuyen Van Duong
1,
Pei-Yu Wu
1,
Evelyn Yang
2,
Yuh-Feng Lin
3,4,
Hung-Yi Chiou
5,6,7 and
Shwu-Huey Yang
1,8,9,*
1
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan
2
Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan
3
International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
4
Division of Nephrology, Department of Internal Medicine, Taipei Medical University−Shuang Ho Hospital, New Taipei 23561, Taiwan
5
School of Public Health, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan
6
Health and Clinical Research Data Center, Data Center, Taipei Medical University, Taipei 11031, Taiwan
7
Master Program in Applied Molecular Epidemiology, Taipei Medical University, Taipei 11031, Taiwan
8
Research Center of Geriatric Nutrition, Taipei Medical University, Taipei 11031, Taiwan
9
Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(24), 5093; https://doi.org/10.3390/ijerph16245093
Submission received: 6 November 2019 / Revised: 6 December 2019 / Accepted: 12 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Chronic Kidney Disease)
Browse Figure
Versions Notes

Abstract

:
Background: Chronic kidney disease (CKD) places a heavy burden on the healthcare system worldwide. The risk factors may vary by body adiposity. We aimed to investigate the associations of socioeconomic, environmental, and behavioral factors with CKD in different groups of body mass indexes (BMI). Methods: A case-control study was conducted in 3280 participants (1048 CKD and 2232 non-CKD) from seven hospitals and nearby communities from May 2012 to August 2015. Personal characteristics, anthropometrics, environmental exposures, and health−related behaviors were assessed using a structured questionnaire. The logistic regression models were utilized for analysis. Results: Older age (odd ratio, OR = 2.85; p < 0.001), being men (OR = 4.23; p < 0.001), smoking (OR = 3.36; p < 0.001), stable income (OR = 0.33; p < 0.001), higher education (OR = 0.37~0.38; p < 0.001), and daily adequate water intake (OR = 0.64; p = 0.010) were associated with CKD in normal weight people. Older age (OR = 2.49; p < 0.001), being men (OR = 3.36; p < 0.001), education (OR = 0.44, p = 0.004), hypertension (OR = 2.93; p<0.001), diabetes (OR = 1.83; p = 0.004), and using traditional Chinese medicine (OR = 2.03, p = 0.014) were associated with CKD in overweight people. Older age (OR = 2.71; p < 0.001), being men (OR = 2.69; p < 0.001), hypertension (OR = 2.93; p < 0.001), diabetes (OR = 1.94; p = 0.001) were associated with CKD in obese people. Conclusions: The associated factors of CKD varied by different groups of BMI. These findings may help to develop potential interventions to manage CKD.

1. Introduction

Chronic kidney disease (CKD) is a major public health issue and significantly contributes to morbidity and mortality globally [1]. CKD places a heavy burden on the healthcare system in every country [2]. The global prevalence of CKD was 10–15% in the general populations [3,4,5], and about 36% in high-risk populations [5]. Taiwan experiences a high prevalence of CKD [6,7,8], and is one of leading countries with highest prevalence of end-stage renal disease [9]. Moreover, awareness of the disease and its risk factors is low in general populations in 12 countries from six world regions [5], and in Taiwan as well [7,10].
It is the consensus that the optimal management of CKD includes cardiovascular risk reduction, treatment of albuminuria, avoidance of potential nephrotoxins, and adjustments to drug dosing [11]. However, factors like socioeconomic, environmental, and behavioral factors have been believed to be important in management of CKD, but have not yet been delineated. From an international perspective, a multidisciplinary, multi−sector, and multifaceted action plan is needed to develop a strategy to prevent and manage CKD in order to combat its burden and complications [4,12]. In Taiwan, the multidisciplinary care helps to slow down the renal progression and improve survival rate [13]. In addition, the risk factors of CKD in people with normal weight, overweight, and obese might be varied. Therefore, we aimed to explore the association between personal characteristics, socioeconomic, environmental factors, and health-related behaviors with CKD in normal, overweight, and obese people.

2. Methods

2.1. Study Design and Settings

A case-control study was conducted in seven hospitals and the communities nearby from May 2012 to August 2015. Hospitals selected for study included Tri-Service General Hospital (TSGH), Cardinal Tien Hospital (CTH), Shuang Ho Hospital (SHH), China Medical University Hospital (CMUH), Kaohsiung Medical University Hospital (KMUH), Changhua Christian Hospital (CCH), Kaohsiung Chang Gung Memorial Hospital (KCGMH).

2.2. Sampling and Sample Size

Participants recruited were Taiwanese citizens aged 18 years or older, who understand Mandarin Chinese. We excluded participants who were diagnosed as CKD stage 5 or end-stage renal disease (ESRD), or who lacked renal function parameters. Cases were patients with chronic kidney disease stage 1 to stage 4. Controls were non-CKD patients, relatives of CKD patients, healthy people who underwent annual health checks, and in the communities around the selected hospitals. The final sample for analysis was 3280 participants with N = 1048 cases, and N = 2232 controls (Figure 1).

2.3. Instruments and Assessments

Participants’ characteristics: Participants were asked to provide their age (years), gender (male vs. female), blood type (O, A, B, AB), marital status (single, married/cohabited, separated/divorced/widow), education attainment (elementary and below, junior high school, senior high school, college/university and above), occupation (unemployed, employed), monthly household income (unstable income, stable income), and medical history (hypertension, diabetes mellitus, hyperlipidemia).
Anthropometrics: Body weight, height, and waist circumference (WC) were measured. Abdominal obesity was defined as WC ≥ 90 cm for men and WC ≥ 80 cm for women [14,15]. Body mass index (BMI) was calculated as weight (kg)/[height (m)]2. BMI was classified into normal weight (BMI < 24.0 kg/m2), overweight (24.0 kg/m2 ≤ BMI < 27.0 kg/m2), and obese (BMI ≥ 27.0 kg/m2) [16].
Environmental exposures: Participants were asked to provide information regarding past expose to environmental risk factors such as pesticides, animals (keeping pets or poultry, slaughtering or selling chicken, ducks, etc.), chemicals (asbestos, heavy metal lead, mercury, polychlorinated biphenyls, etc.), and organic solvents or compounds (e.g., gasoline, derivatives, plywood adhesives, paints, methane, rosin, etc.).
Health-related behaviors: The behaviors assessed included daily intake of water (<1.5 L/day vs. ≥1.5 L/day), using traditional Chinese medicine products (yes vs. no), smoking tobacco (yes vs. no), drinking alcohol (yes vs. no), and chewing betel nut (yes vs. no). Betel quid and areca nut, called betel nut, is widely used as plant chewing gum in Asian communities [17]. It was summarized that betel nut chewing was associated with increased CKD risk [18]. To evaluate physical activity level, the short version of the International Physical Activity Questionnaire (IPAQ), a widely used method, was utilized [19]. Patients were asked to provide information on their time spent (days per week, and minutes per day) on different levels of physical intensity (vigorous, moderate, walking, and sitting). The overall physical activity score was given by calculating the sum of minutes spent on activities at different levels of vigorous, moderate, walking, and sitting over the last seven days multiplied by 8.0, 4.0, and 3.3, 1.0, respectively [19]. The common method using metabolic equivalent task scored in minute per week (named as MET-min/wk) was used to represent the physical activity [20].
CKD classification: Kidney function parameters were analyzed in the hospital laboratories and the results were shown in medical records. The estimated glomerular filtration rate (eGFR, mL/min/1.73 m2) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD−EPI) equation [21]. eGFR = 141 × min (SCr/κ, 1)α × max (SCr/κ, 1)−1.209 × 0.993Age × (1.018 if female) × (1.159 if black)], where κ = 0.7 (female) and 0.9 (male), α = −0.329 (female) and −0.411 (male), serum creatinine (SCr, mg/dL), min indicated the minimum of SCr/κ or 1, and max indicated the maximum of SCr/κ or 1.
Nurses then checked to confirm the stage of CKD for each participant. CKD was classified into different stages: Stage 1 as an eGFR ≥ 90.0 mL/min/1.73 m2, and the presence of kidney damage (e.g., proteinuria dipsticks ≥1+, urine protein-to-creatinine ratio [UPCR] ≥ 150, or urine albumin-to-creatinine ratio [UACR] ≥ 30); Stage 2 as an eGFR = 60.0–89.9 mL/min/1.73 m2, and the presence of kidney damage (e.g., proteinuria dipsticks ≥ 1+, UPCR ≥ 150, or UACR ≥ 30); Stage 3a as an eGFR = 45.0–59.9 mL/min/1.73 m2; Stage 3b as an eGFR = 30.0–44.9 mL/min/1.73 m2; Stage 4 as an eGFR = 15.0–29.9 mL/min/1.73 m2; and Stage 5 as an eGFR < 15.0 mL/min/1.73 m2 [22]. Participants were defined as non-CKD only if they had an eGFR ≥ 60.0 mL/min/1.73 m2, and did not have any evidence of kidney damage [22].

2.4. Data Collection Procedures

Interviewers were seven research assistants from seven hospitals. They received 4 h of training for data collection. Patients and healthy people participated in the study voluntarily and were checked by research assistants for eligibility. The face-to-face interviews were conducted in hospitals or in community activity stations. After interviews, blood specimens were collected by registered nurses and then were analyzed in hospital laboratories to determine renal function parameters. The same laboratory criteria and protocol were adopted for all hospitals involved. The diagnosis of CKD was based on the hospital laboratory results. All the misclassification of patients from interviews or lack of renal function parameters were excluded from final sample. The study procedure was recapped in Figure 1.

2.5. Ethical Approvals

The study protocol was approved by the ethical committee of Taipei Medical University Joint Institutional Review Board of Taipei Medical University (TMU-JIRB No. 201204036). All participants signed the written informed consent form before their participation.

2.6. Data Analysis

The studied variables were described as mean and standard deviation, frequency and percentage, median and interquartile range. The independent-samples T-test and one-way ANOVA test, and the Mann Whitney test were used to compare the distribution of studied variables between non-CKD and CKD groups, appropriately. Finally, the bivariate logistic regression model was used to examine the associations of participants’ characteristics, medical history, health-related behaviors with CKD in the overall sample, in the group with normal weight, and in the overweight/obese group. Variables selected into the multivariate logistic regression model were those that showed the association with CKD at p < 0.20 from the bivariate model [23]. In order to avoid multicollinearity in the multivariate analysis, the Spearman correlation was utilized to check the correlations between selected variables. Analysis was conducted using the IBM SPSS software version 20.0 for Windows (IBM Corp., Armonk, NY, USA). The significant level was set at p-value < 0.05.

3. Results

The average age of the study population was 60.5 ± 13.2 years, 47.3% were men, 29.2% were overweight, and 24.6% were obesity. The prevalence of CKD was varied by different categories of age, gender, blood type, BMI, WC, marital status, education, occupation, household income, history of diseases, exposure to pesticide and animal, daily intake of plain water, smoking, chewing betel nut, and physical activities (Table 1).
In the overall sample, results of simple regression analysis showed that age, gender, blood type, BMI, WC, marital status, education, occupation, income, hypertension, diabetes, hyperlipidemia, exposure to pesticide and animal, daily intake of plain water, smoking, and chewing betel nut were significantly associated with CKD (Table 2). Furthermore, the correlations between variables (associated with CKD at p < 0.20) were examined. Moderate correlations were found between WC and BMI (r = 0.52), age and education (r = −0.31), gender and smoking (r = 0.48), smoking and betel nut (r = 0.47) (Table S1). Age, gender, WC, betel nut, and other factors were analyzed in the multivariate analysis. We found that factors showing significantly positive association with CKD were age ≥65 years (odd ratio, OR, 2.43; 95% confidence interval, 95% CI, 1.93–3.07; p < 0.001), men (OR, 2.96; 95% CI, 2.32–3.78; p < 0.001), abdominal obesity (OR, 1.52; 95% CI, 1.21–1.91; p < 0.001), hypertension (OR, 4.35; 95% CI, 3.46–5.47; p < 0.001), diabetes mellitus (OR, 1.36; 95% CI, 1.07–1.72; p = 0.011), and exposure to animals (OR, 1.37; 95% CI, 1.04–1.80; p = 0.027; Table 3). Factors showing the negative association with CKD were married/cohabited status (OR, 0.60; 95% CI, 0.38–0.96; p = 0.031), stable income (OR, 0.61; 95% CI, 0.48–0.76; p < 0.001), and drinking ≥ 1.5 L/day plain water (OR, 0.69; 95% CI, 0.56–0.87; p = 0.001; Table 3).
In the normal weight group, results of simple regression analysis showed that age, gender, WC, marital status, education, occupation, income, hypertension, diabetes, hyperlipidemia, exposure to animals, daily intake of plain water, and smoking were significantly associated with CKD (Table 2). Moderate correlations were existed between age and education (r = −0.32), age and history of hypertension (r = −0.33), gender and smoking (r = 0.46), smoking and chewing betel nut (r = 0.44) (Table S1). Age, gender, chewing betel nut, and other factors were analyzed in the multivariate analysis. We found that the factors significantly positively associated with CKD were age ≥65 years (OR, 2.85; 95% CI, 2.00–4.06; p < 0.001), men (OR, 4.23; 95% CI, 2.88–6.19; p < 0.001). The factors showing the negative association with CKD were stable income (OR, 0.33; 95% CI, 0.23–0.47; p < 0.001), and drinking ≥1.5 L/day of plain water (OR, 0.64; 95% CI, 0.46–0.90; p = 0.010; Table 3).
In the overweight group, results of simple regression analysis showed that age, gender, WC, marital status, education, occupation, income, hypertension, diabetes, hyperlipidemia, and smoking were significantly associated with CKD (Table 2). Moderate correlations were existed between gender and smoking (r = 0.46), smoking and chewing betel nut (r = 0.45) (Table S1). Gender, chewing betel nut, and other factors were analyzed in the multivariate analysis. We found that the factors showing significantly positive association with CKD were age ≥65 years (OR, 2.49; 95% CI, 1.62–3.82; p < 0.001), being men (OR, 3.36; 95% CI, 2.07–5.45; p < 0.001), hypertension (OR, 2.93; 95% CI, 1.95–4.40; p < 0.001), diabetes (OR, 1.83; 95% CI, 1.21–2.78; p = 0.004), using traditional Chinese medicine (TCM) products (OR, 2.03; 95% CI, 1.15–3.56; p = 0.014). Factors showing negative associations with CKD was education at vocational/college/ or university level (OR, 0.44; 95% CI, 0.25–0.77; p = 0.004; Table 3).
In the obese group, results of simple regression analysis showed that age, gender, blood type, WC, education, income, history of hypertension, diabetes, hyperlipidemia, exposure to pesticides, daily intake of plain water, and smoking were significantly associated with CKD (Table 2). Moderate correlations were observed between age and education (r = −0.34), gender and smoking (r = 0.51), gender and chewing betel nut (r = 0.33), smoking and chewing betel nut (r = 0.51; Table S1). Age, gender, and other factors were analyzed in the multivariate model. We found that the factors showing significantly positive association with CKD were age ≥65 years (OR, 2.71; 95% CI, 1.81–4.05; p < 0.001), being men (OR, 2.69; 95% CI, 1.75–4.16; p < 0.001), hypertension (OR, 2.93; 95% CI, 1.96–4.37; p < 0.001), diabetes (OR, 1.94; 95% CI, 1.29–2.91; p = 0.001; Table 3).

4. Discussion

The current study showed that people aged ≥65 years had a higher likelihood of CKD. Age was found to be a risk factor of CKD in previous studies [24,25,26]. Additionally, our study showed that men have a higher probability of having CKD than women. Note that, across all regions, it has been shown that men were closely associated with the occurrence of CKD [27]; by contrast, in other parts of the world such as in China, Switzerland, and Iran, women had a higher risk of CKD than men [24,28,29]. In China, authors analyzed people with eGFR ≥ 60.0 mL/min/1.73 m2 [24], while we analyzed people with CKD at stage 1 to stage 4, the different selection criteria might affect the results. In Switzerland and Iran, the different genetic background might contribute to this contradiction [30]. Based on this evidence, we conclude that gender should be taken into account when developing strategical approaches to prevent and treat CKD and its complications [31]. Moreover, we found that people with higher education and stable income had a lower likelihood of having CKD, a finding consistent with previous studies showing that low socioeconomic status (low education, occupation, and income) was strongly associated with a higher risk of having CKD [32,33].
In the multivariate model, being married or cohabited had a lower likelihood of having CKD as compared with being unmarried in the overall sample. This could be explained by the previous evidence that being unmarried or living alone was associated with higher systolic blood pressure [34], a high prevalence of hypertension [35], and lower hypertension awareness and control rate [36,37]. Hypertension has been proven to be a strong predictor of CKD [24]. In addition, married people had lower prevalence of diabetes and smoking [38]. Diabetes [39,40], and smoking [26] were recognized as important predictors of CKD. Taken together, married or cohabited people had lower blood pressure, higher hypertension awareness and control, and lower prevalence of diabetes and smoking, which, in turn, led to a lower risk of CKD as compared with unmarried people.
Our study illustrated that people with hypertension and diabetes had a higher likelihood of CKD. It has been proven that hypertension is a cause and complication of CKD [24,41,42,43]. In addition, diabetes was one of the most common causes of CKD [39,40,43]. On the other hand, insulin resistance was independently associated with cardiovascular risks in ESRD patients [44]. Therefore, there is a consensus that better management of hypertension, and diabetes is required to improve CKD patient care [45,46,47].
Our data showed that, general overweight and obesity was positively associated with a higher likelihood of CKD in the overall sample. The previous evidence showed that obesity measured by different adiposity indices (percentage body fat, visceral fat index, body mass index, waist circumference, and waist-to-height ratio) was significantly associated with increased risk of having CKD [48]. In addition, results of bivariate analysis showed that elevated WC was significantly associated with higher prevalence of CKD in the overall sample, in overweight, and in obese individuals as well. This was partly supported by the evidence that the effect of obesity in triggering CKD was only significant in the obese population [49].
Our study showed that people exposed to animals had a higher CKD occurrence. This might be explained by environmental factors also being a common cause of CKD [39]. In addition, people who had a daily intake of plain water ≥1.5 L of plain water had a lower likelihood of developing CKD. Water is an essential nutrient for body hydration [50]. A previous study showed that increasing daily water consumption slowed down the progression of CKD [51]. Moreover, overweight people using traditional Chinese medicine (TCM) products had a higher rate of CKD as compared to those did not use. A number of studies found the adverse effect of TCM on CKD [52]. However, the evidence is insufficient, the practice of TCM in varied, rigorous, well−designed studies is required to provide evidence-based practices to improve the safety and efficacy [52].
Current smoking was associated with a higher prevalence of CKD in the current study. Smoking has been recognized as a risk factor for CKD in both men and women [26], and smoking increased the risk for cardiovascular events, ESRD, and mortality in CKD patients [53,54]. Alcohol consumption was not associated with CKD in our study. This could be explained that the quality of alcohol was not measured in the current study. The previous study showed that alcohol intake was associated with incident CKD [55]. It is suggested that limited alcohol consumption could minimize the health risks [56] and delay CKD progression [57].
This study had some limitations. Firstly, a causal relationship cannot be drawn from a cross-sectional design. However, the findings from this study might be useful for future epidemiological studies or public health programs. Secondly, study indicators were subjectively assessed using a structured questionnaire. However, considering that (1) interviewers were well-trained for data collection, and (2) Taiwanese people have high self-awareness in personal health under universal health coverage policy. These factors may reduce the interview bias. Future studies with a larger sample and better study design are suggested to comprehensively explore the risk factors and assure the causality.

5. Conclusions

In normal weight people, older age, being men, and smoking were associated with a higher prevalence of CKD, while stable income and drinking enough daily plain water were associated with a lower prevalence of CKD. In overweight people, older age, being men, history of hypertension, diabetes, using TCM products, and smoking were associated with a higher prevalence of CKD, while higher education status was found to be a protective factor of CKD. In obese people, older age, being men, history of hypertension, diabetes, and smoking were associated with a higher rate of CKD. The evidence obtained from this study may help to improve multifaceted strategical interventions to prevent and manage CKD.

Supplementary Materials

The following are available online at https://www.mdpi.com/1660-4601/16/24/5093/s1, Table S1. The Spearman correlation among the variables associated with chronic kidney disease at p < 0.20.

Author Contributions

Conceptualization, T.V.D., P.-Y.W., E.Y., Y.-F.L., H.-Y.C., S.-H.Y.; data curation, T.V.D., P.-Y.W., E.Y., Y.-F.L., H.-Y.C., S.-H.Y.; formal analysis, T.V.D.; funding acquisition, Y.-F.L.; investigation, T.V.D., P.-Y.W., E.Y., Y.-F.L., H.-Y.C., S.-H.Y.; methodology, T.V.D., P.-Y.W., E.Y., Y.-F.L., H.-Y.C., S.-H.Y.; resources, Y.-F.L., H.-Y.C., S.-H.Y.; software, T.V.D.; supervision, Y.-F.L., H.-Y.C., S.-H.Y.; validation, T.V.D., P.-Y.W., E.Y., Y.-F.L., H.-Y.C., S.-H.Y.; visualization, T.V.D.; writing-original draft preparation, T.V.D., P.-Y.W., E.Y., Y.-F.L., H.-Y.C., S.-H.Y.; writing-review and editing, T.V.D., P.-Y.W., E.Y., Y.-F.L., H.-Y.C., S.-H.Y.

Funding

The research was funded by the Health Promotion Administration, Ministry of Health and Welfare, Taiwan (DOH101-HP-1103, DOH102-HP-1103, MOHW103-HPA-H-114-134101, MOHW104-HPA-H-114-134101). The funder had no role in the decision to collect data, data analysis, or reporting of the results.

Acknowledgments

The authors would like to thank the medical staff, research assistants who helped with data collection.

Conflicts of Interest

The authors declare no conflicts of interest.

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Ijerph 16 05093 g001 550
Figure 1. Study flow chart. TSGH, Tri-Service General Hospital; CTH, Cardinal Tien Hospital; SHH, Shuang Ho Hospital; CMUH, China Medical University Hospital; KMUH, Kaohsiung Medical University Hospital; CCH, Changhua Christian Hospital; KCGMH, Kaohsiung Chang Gung Memorial Hospital; WC, waist circumference; BMI, body mass index; CKD, chronic kidney disease; ESRD, end stage renal disease.
Figure 1. Study flow chart. TSGH, Tri-Service General Hospital; CTH, Cardinal Tien Hospital; SHH, Shuang Ho Hospital; CMUH, China Medical University Hospital; KMUH, Kaohsiung Medical University Hospital; CCH, Changhua Christian Hospital; KCGMH, Kaohsiung Chang Gung Memorial Hospital; WC, waist circumference; BMI, body mass index; CKD, chronic kidney disease; ESRD, end stage renal disease.
Ijerph 16 05093 g001
Table
Table 1. Participants’ characteristics.
Table 1. Participants’ characteristics.
VariablesTotal
(N = 3280)		Non−CKD
(N = 2232)		CKD
(N = 1048)
n (%)n (%)n (%)p-value *
Age, year, mean ± SD60.5 ± 13.257.6 ± 12.266.7 ± 13.2<0.001
Age groups <0.001
<652022 (61.6)1599 (71.6)423 (40.4)
≥651258 (38.4)633 (28.4)625 (59.6)
Gender <0.001
Women1728 (52.7)1361 (61.0)367 (35.0)
Men1552 (47.3)871 (39.0)681 (65.0)
Blood type 0.002
O1247 (44.5)853 (44.4)394 (44.7)
A758 (27.1)534 (27.8)224 (25.4)
B626 (22.3)400 (20.8)226 (25.7)
AB170 (6.1)133 (6.9)37 (4.2)
BMI, kg/m2 <0.001
BMI < 24.01516 (46.2)1128 (50.5)388 (37.0)
24.0 ≤ BMI < 27.0956 (29.2)647 (29.0)309 (29.5)
BMI ≥ 27.0808 (24.6)457 (20.5)351 (33.5)
WC, cm <0.001
Normal1565 (55.5)1193 (60.6)372 (43.8)
Abdominal obesity1253 (44.5)776 (39.4)477 (56.2)
Marital status <0.001
Single241 (7.4)186 (8.4)55 (5.3)
Married/Cohabited2667 (81.7)1822 (82.0)845 (81.0)
Divorce/separate/widow356 (10.9)213 (9.6)143 (13.7)
Education <0.001
Elementary and below958 (29.3)533 (24.0)425 (40.6)
Secondary school423 (12.9)266 (12.0)157 (15.0)
High school845 (25.9)619 (27.9)226 (21.6)
Vocational/College/University1042 (31.9)803 (36.2)239 (22.8)
Occupation <0.001
Unemployed209 (6.4)105 (4.7)104 (10.1)
Employed3034 (93.6)2111 (95.3)923 (89.9)
Monthly household income <0.001
Unstable income1177 (37.4)642 (30.5)535 (51.5)
Stable income1970 (62.6)1466 (69.5)504 (48.5)
Medical history
Hypertension <0.001
No1934 (60.4)1620 (75.1)314 (30.1)
Yes1267 (39.6)538 (24.9)729 (69.9)
Diabetes <0.001
No2328 (72.7)1698 (78.7)630 (60.4)
Yes873 (27.3)460 (21.3)413 (39.6)
Hyperlipidemia <0.001
No2618 (81.8)1842 (85.4)776 (74.4)
Yes583 (18.2)316 (14.6)267 (25.6)
Environmental factors
Exposure to pesticides 0.007
No2922 (96.4)1972 (97.0)950 (95.1)
Yes109 (3.6)60 (3.0)49 (4.9)
Exposure to animals 0.017
No2429 (80.1)1653 (81.3)776 (77.7)
Yes602 (19.9)379 (18.7)223 (22.3)
Exposure to chemicals 0.153
No2960 (97.7)1990 (97.9)970 (97.1)
Yes71 (2.3)42 (2.1)29 (2.9)
Exposure to solvents 0.120
No2901 (95.7)1953 (96.1)948 (94.9)
Yes130 (4.3)79 (3.9)51 (5.1)
Health-related behaviors
Daily intake of plain water <0.001
<1.5 L/day1604 (48.9)1020 (45.7)584 (55.7)
≥1.5 L/day1676 (51.1)1212 (54.3)464 (44.3)
Using TCM products 0.195
No2559 (83.3)1707 (83.9)852 (82.1)
Yes513 (16.7)327 (16.1)186 (17.9)
Smoking tobacco <0.001
No2514 (78.8)1834 (85.2)680 (65.4)
Yes677 (21.2)318 (14.8)359 (34.6)
Drinking alcohol 0.349
No2601 (81.8)1761 (82.2)840 (80.8)
Yes580 (18.2)381 (17.8)199 (19.2)
Chewing betel nut <0.001
No2914 (91.9)1985 (93.2)929 (89.2)
Yes256 (8.1)144 (6.8)112 (10.8)
PA, METs-min/wk1080.0 (594.0–2034.0)1116.0 (600.0–2118.0)1032.0 (594.0–1813.0)0.041
Abbreviations: CKD, chronic kidney disease; SD, standard deviation; BMI, body mass index; WC, waist circumference; TCM, traditional Chinese medicine; PA−METs, physical activity measured in metabolic equivalents (min/week). * Data were presented as mean ± SD, frequency and percentage, median (interquartile range) and p-values were calculated using independent sample t-test, Chi-square test, and Mann Whitney test, appropriately.
Table
Table 2. The associated factors of CKD in the overall sample, in the groups with normal weight, overweight, and obesity using simple logistic regression models.
Table 2. The associated factors of CKD in the overall sample, in the groups with normal weight, overweight, and obesity using simple logistic regression models.
VariablesTotal
(N = 3280)		 BMI < 24.0
(N = 1516)		 24.0 ≤ BMI < 27.0
(N = 956)		 BMI ≥ 27.0
(N = 808)
OR (95% CI)pOR (95% CI)pOR (95% CI)pOR (95% CI)p
Age groups
  <65Reference Reference Reference Reference
  ≥653.73 (3.20–4.35)<0.0014.43 (3.47–5.66)<0.0014.26 (3.20–5.67)<0.0012.77 (2.07–3.71)<0.001
Gender
  WomenReference Reference Reference Reference
  Men2.90 (2.49–3.38)<0.0013.52 (2.77–4.48)<0.0012.39 (1.80–3.17)<0.0012.33 (1.75–3.10)<0.001
Blood type
  OReference Reference Reference Reference
  A0.91 (0.75–1.11)0.3360.96 (0.71–1.29)0.7770.85 (0.58–1.23)0.3900.93 (0.64–1.36)0.722
  B1.22 (1.00–1.50)0.0510.97 (0.70–1.35)0.8571.40 (0.97–2.01)0.0721.48 (1.00–2.19)0.050
  AB0.60 (0.41–0.88)0.0100.67 (0.35–1.25)0.2040.62 (0.32–1.19)0.1480.47 (0.23–0.97)0.042
BMI, kg/m2
  BMI < 24.0Reference
  24.0 ≤ BMI < 27.01.39 (1.16–1.66)<0.001
  BMI ≥ 27.02.23 (1.86–2.68)<0.001
WC, cm
  NormalReference Reference Reference Reference
  Abdominal obesity1.97 (1.68–2.32)< 0.0011.45 (1.05–2.01)0.0261.52 (1.12–2.05)0.0071.76 (1.14–2.72)0.011
Marital status
  SingleReference Reference Reference Reference
  Married/Cohabited1.57 (1.15–2.14)0.0052.12 (1.28–3.49)0.0031.94 (0.92–4.08)0.0810.91 (0.53–1.54)0.716
  Divorce/separate/widow2.27 (1.57–3.28)<0.0012.90 (1.62–5.18)<0.0012.74 (1.19–6.29)0.0171.59 (0.82–3.08)0.168
Education
  Elementary and belowReference Reference Reference Reference
  Secondary school0.74 (0.59–0.94)0.0120.76 (0.52–1.11)0.1570.73 (0.46–1.14)0.1610.73 (0.48–1.11)0.137
  High school0.46 (0.38–0.56)<0.0010.38 (0.28–0.53)<0.0010.59 (0.41–0.84)0.0040.54 (0.38–0.79)0.001
  Vocational/College/University0.37 (0.31–0.45)<0.0010.37 (0.27–0.50)<0.0010.44 (0.31–0.62)<0.0010.42 (0.29–0.61)<0.001
Occupation
  UnemployedReference Reference Reference Reference
  Employed0.44 (0.33–0.59)<0.0010.40 (0.26–0.62)<0.0010.36 (0.21–0.60)<0.0010.67 (0.40–1.14)0.138
Monthly household income
  Unstable incomeReference Reference Reference Reference
  Stable income0.41 (0.35–0.48)<0.0010.35 (0.27–0.45)<0.0010.55 (0.42–0.73)<0.0010.45 (0.34–0.60)<0.001
Medical history
Hypertension
  NoReference Reference Reference Reference
  Yes6.99 (5.93–8.24)<0.0018.98 (6.91–11.67)<0.0014.14 (3.10–5.54)<0.0017.12 (5.11–9.91)<0.001
Diabetes
  NoReference Reference Reference Reference
  Yes2.42 (2.06–2.84)<0.0012.42 (1.85–3.18)<0.0012.12 (1.59–2.83)<0.0012.07 (1.54–2.77)<0.001
Hyperlipidemia
  NoReference Reference Reference Reference
  Yes2.01 (1.67–2.41)<0.0011.89 (1.40–2.55)<0.0011.55 (1.09–2.20)0.0152.20 (1.58–3.05)<0.001
Environmental factors
Exposure to pesticides
  NoReference Reference Reference Reference
  Yes1.70 (1.15–2.49)0.0071.19 (0.58–2.44)0.6301.28 (0.59–2.78)0.5272.06 (1.10–3.85)0.023
Exposure to animals
  NoReference Reference Reference Reference
  Yes1.25 (1.04–1.51)0.0171.35 (1.01–1.81)0.0431.10 (0.78–1.56)0.5881.21 (0.85–1.71)0.291
Exposure to Chemicals
  NoReference Reference Reference Reference
  Yes1.42 (0.88–2.29)0.1551.05 (0.49–2.29)0.8961.59 (0.62–4.07)0.3351.90 (0.77–4.70)0.165
Exposure to solvents
  NoReference Reference Reference Reference
  Yes1.33 (0.93–1.91)0.1211.39 (0.79–2.43)0.2541.67 (0.83–3.37)0.1500.96 (0.50–1.84)0.902
Health-related behaviors
Daily intake of plain water
  <1.5 L/dayReference Reference Reference Reference
  ≥1.5 L/day0.67 (0.58–0.78)<0.0010.57 (0.45–0.72)<0.0010.80 (0.61–1.05)0.1150.64 (0.48–0.84)0.002
Using TCM products
  NoReference Reference Reference Reference
  Yes1.14 (0.94–1.39)0.1960.94 (0.69–1.29)0.7011.41 (0.98–2.03)0.0641.24 (0.85–1.81)0.271
Smoking tobacco
  NoReference Reference Reference Reference
  Yes3.05 (2.56–3.63)<0.0013.36 (2.53–4.47)<0.0012.70 (1.96–3.70)<0.0012.51 (1.82–3.45)<0.001
Drinking alcohol
  NoReference Reference Reference Reference
  Yes1.10 (0.91–1.32)0.3501.25 (0.92–1.70)0.1570.97 (0.68–1.37)0.8410.91 (0.64–1.28)0.587
Chewing betel nut
  NoReference Reference Reference Reference
  Yes1.66 (1.28–2.15)<0.0011.53 (0.95–2.48)0.0831.44 (0.91–2.26)0.1201.52 (0.99–2.35)0.057
PA, METs-min/wk
  1st tertileReference Reference Reference Reference
  2nd tertile0.93 (0.77–1.13)0.4640.82 (0.60–1.11)0.1970.97 (0.68–1.38)0.8721.14 (0.78–1.65)0.501
  3rd tertile1.01 (0.84–1.23)0.8851.00 (0.74–1.35)0.9931.08 (0.75–1.55)0.6781.12 (0.76–1.65)0.564
Abbreviations: CKD, chronic kidney disease; BMI, body mass index; OR, odds ratio; CI, confidence interval; WC, waist circumference; TCM, traditional Chinese medicine; PA, physical activity; METs, metabolic equivalents (min/week).
Table
Table 3. The associated factors of CKD in overall sample, in the groups with normal weight, overweight, and obesity using multiple logistic regression models.
Table 3. The associated factors of CKD in overall sample, in the groups with normal weight, overweight, and obesity using multiple logistic regression models.
VarialesTotal
(N = 3280)		 BMI < 24.0
(N = 1516)		 24.0 ≤ BMI < 27.0
(N = 956)		 BMI ≥ 27.0
(N = 808)
OR (95% CI)pOR (95% CI)pOR (95% CI)pOR (95% CI)p
Age groups
  <65Reference Reference Reference Reference
  ≥652.43 (1.93–3.07)<0.0012.85 (2.00–4.06)<0.0012.49 (1.62–3.82)<0.0012.71 (1.81–4.05)<0.001
Gender
  WomenReference Reference Reference Reference
  Men2.96 (2.32–3.78)<0.0014.23 (2.88–6.19)<0.0013.36 (2.07–5.45)<0.0012.69 (1.75–4.16)<0.001
Blood type
  OReference Reference Reference
  A0.96 (0.74–1.26)0.775 0.85 (0.51–1.40)0.5170.80 (0.49–1.31)0.379
  B1.17 (0.89–1.55)0.264 1.53 (0.93–2.51)0.0941.45 (0.89–2.35)0.137
  AB0.71 (0.43–1.16)0.170 0.65 (0.28–1.50)0.3110.64 (0.28–1.45)0.284
WC, cm
  NormalReference Reference Reference Reference
  Abdominal obesity1.52 (1.21–1.91)<0.0011.31 (0.83–2.06)0.2431.32 (0.86–2.03)0.1991.34 (0.88–2.03)0.172
Marital status
  SingleReference Reference Reference Reference
  Married/Cohabited0.60 (0.38–0.96)0.0310.98 (0.46–2.07)0.9480.74 (0.27–2.05)0.5600.85 (0.31–2.32)0.754
  Divorce/separate/widow0.86 (0.49–1.50)0.5911.44 (0.60–3.45)0.4130.91 (0.28–2.90)0.8691.15 (0.37–3.59)0.806
Education
  Elementary and below Reference
  Secondary school 0.68 (0.36–1.27)0.226
  High school 0.63 (0.36–1.12)0.119
  Vocational/College/University 0.44 (0.25–0.77)0.004
Occupation
  UnemployedReference Reference Reference Reference
  Employed0.71 (0.45–1.12)0.1420.63 (0.31–1.30)0.2120.66 (0.30–1.46)0.3060.64 (0.30–1.38)0.257
Monthly household income
  Unstable incomeReference Reference Reference Reference
  Stable income0.61 (0.48–0.76)<0.0010.33 (0.23–0.47)<0.0010.96 (0.63–1.46)0.8390.82 (0.55–1.22)0.321
Medical history
Hypertension
  NoReference Reference Reference
  Yes4.35 (3.46–5.47)<0.001 2.93 (1.95–4.40)<0.0012.93 (1.96–4.37)<0.001
Diabetes
  NoReference Reference Reference Reference
  Yes1.36 (1.07–1.72)0.0111.05 (0.71–1.55)0.8161.83 (1.21–2.78)0.0041.94 (1.29–2.91)0.001
Hyperlipidemia
  NoReference Reference Reference Reference
  Yes1.29 (0.98–1.69)0.0701.44 (0.92–2.25)0.1111.16 (0.68–1.97)0.5901.09 (0.64–1.83)0.759
Environmental factors
Exposure to pesticides
  NoReference Reference
  Yes1.38 (0.76–2.51)0.287 1.22 (0.44–3.37)0.702
Exposure to animals
  NoReference Reference
  Yes1.37 (1.04–1.80)0.0271.48 (0.98–2.24)0.060
Exposure to Chemicals
  NoReference Reference
  Yes1.07 (0.51–2.25)0.857 1.57 (0.37–6.73)0.542
Exposure to solvents
  NoReference Reference
  Yes1.21 (0.70–2.11)0.490 1.06 (0.35–3.23)0.921
Health-related behaviors
Daily intake of plain water
  <1.5 L/dayReference Reference Reference Reference
  ≥1.5 L/day0.69 (0.56–0.87)0.0010.64 (0.46–0.90)0.0100.72 (0.48–1.07)0.1000.71 (0.48–1.05)0.087
Using TCM products
  NoReference Reference
  Yes1.35 (0.99–1.83)0.059 2.03 (1.15–3.56)0.014
Drinking alcohol
  No Reference Reference
  Yes 0.93 (0.59–1.47)0.7500.89 (0.52–1.51)0.665
Chewing betel nut
  NoReference Reference Reference
  Yes0.84 (0.57–1.24)0.3720.97 (0.49–1.94)0.9360.92 (0.46–1.86)0.826
PA, METs-min/wk
  1st tertile Reference
  2nd tertile 0.88 (0.57–1.35)0.566
  3rd tertile 1.08 (0.72–1.63)0.708
Abbreviations: CKD, chronic kidney disease; BMI, body mass index; OR, odds ratio; CI, confidence interval; WC, waist circumference; TCM, traditional Chinese medicine; PA, physical activity; METs, metabolic equivalents (min/week).

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MDPI and ACS Style

Duong, T.V.; Wu, P.-Y.; Yang, E.; Lin, Y.-F.; Chiou, H.-Y.; Yang, S.-H. Associations of Waist Circumference, Socioeconomic, Environmental, and Behavioral Factors with Chronic Kidney Disease in Normal Weight, Overweight, and Obese People. Int. J. Environ. Res. Public Health 2019, 16, 5093. https://doi.org/10.3390/ijerph16245093

AMA Style

Duong TV, Wu P-Y, Yang E, Lin Y-F, Chiou H-Y, Yang S-H. Associations of Waist Circumference, Socioeconomic, Environmental, and Behavioral Factors with Chronic Kidney Disease in Normal Weight, Overweight, and Obese People. International Journal of Environmental Research and Public Health. 2019; 16(24):5093. https://doi.org/10.3390/ijerph16245093

Chicago/Turabian Style

Duong, Tuyen Van, Pei-Yu Wu, Evelyn Yang, Yuh-Feng Lin, Hung-Yi Chiou, and Shwu-Huey Yang. 2019. "Associations of Waist Circumference, Socioeconomic, Environmental, and Behavioral Factors with Chronic Kidney Disease in Normal Weight, Overweight, and Obese People" International Journal of Environmental Research and Public Health 16, no. 24: 5093. https://doi.org/10.3390/ijerph16245093

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