Long-Term Response of Pembrolizumab in a Patient with Metastatic Squamous Non-Small Cell Lung Cancer on Hemodialysis: Case Report and Review of the Literature
Abstract
:1. Introduction
2. Case Report
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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No | Age (Year) /Sex | Type of Lung Cancer (Stage) | ICI (Dosage and Duration) | Underlying Kidney Disease | Dialysis Duration after Starting ICI (mo) | TR | PFS (mo) | OS (mo) | Adverse Events | Reference |
---|---|---|---|---|---|---|---|---|---|---|
1 | 66/male | Non-small cell lung cancer (IVB) | Pembrolizumab (~15 doses; 200 mg every 3 weeks) | ESRD due to diabetes mellitus | ~11.3 | PR | 11.3 | NA | Grade 1 rash | Ishizuka et al. [7] |
2 | 72/male | Non-small cell lung cancer- adenocarcinoma (IIIB) | Pembrolizumab (discontinued after a single dose of 200 mg) | NA | 12.5 | CR | >12.5 | >12.5 | Mild ileus and aspiration pneumonia (suspected) | Osa et al. [9] |
3 | 63/male | Squamous cell carcinoma of lung (IV) | Nivolumab (3 doses; 200 mg every 2 weeks) | Membrano-proliferative glomerulo-nephritis and monoclonal nephropathy | ~2.4 | SD | 2.3 | 2.4 | None | Jain et al. [8] |
4 | NA | NA | Atezolizumab (12 doses; 1200 mg every 3 weeks) | NA | 12 | NA * | <9 | <12 | None | Strohbehn et al. [10] |
5 | NA | NA | Pembrolizumab (34 doses; 200 mg every 3 weeks) | NA | ~26 | NA * | >26 | >26 | Hypothyroidism | Strohbehn et al. [10] |
6 | 66/male | Squamous cell carcinoma of lung (initially IIB and progressed) | Pembrolizumab (34 doses; 200 mg every 3 weeks) | CKD due to IgA nephropathy | 49 | PR | 45 | 49 | None | This report |
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Yun, J.W.; Kwon, J.; Lim, T. Long-Term Response of Pembrolizumab in a Patient with Metastatic Squamous Non-Small Cell Lung Cancer on Hemodialysis: Case Report and Review of the Literature. Medicina 2023, 59, 325. https://doi.org/10.3390/medicina59020325
Yun JW, Kwon J, Lim T. Long-Term Response of Pembrolizumab in a Patient with Metastatic Squamous Non-Small Cell Lung Cancer on Hemodialysis: Case Report and Review of the Literature. Medicina. 2023; 59(2):325. https://doi.org/10.3390/medicina59020325
Chicago/Turabian StyleYun, Jae Won, Jung Kwon, and Taekyu Lim. 2023. "Long-Term Response of Pembrolizumab in a Patient with Metastatic Squamous Non-Small Cell Lung Cancer on Hemodialysis: Case Report and Review of the Literature" Medicina 59, no. 2: 325. https://doi.org/10.3390/medicina59020325