The Possible Precipitating Role of SARS-CoV-2 in a Case of Late-Onset Hemichorea Due to a Hyperosmolar Hyperglycemic State: Case Report and Brief Literature Review
Abstract
:1. Introduction
2. Case Report (Figure 1)
3. Brief Review of the Literature
3.1. Role of Hyperosmolar Hyperglycemic State
3.2. SARS-CoV-2 and Movement Disorders
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Cytokine Type | Detection | Normal Range |
---|---|---|
IL-15 | 9.3 pg/mL | 1.9–2.6 pg/mL |
IL-6 | 3.3 pg/mL | 1–3.1 pg/mL |
IL-8 | 94.2 pg/mL | 15.2–38.4 pg/mL |
TNFα | 1.5 pg/mL | <0.5 pg/mL |
CXCL10/IP10 | 633 pg/mL | 6–132 pg/mL |
IL-2 receptor α | 148 pg/mL | 5.7–19.4 pg/mL |
Neurofilaments | 2570 pg/mL | 62–514 pg/mL |
Name of the Study | Gender, Age | Risk Factors | Glycemia at First Evaluation | Symptoms at First Evaluation | Late-Onset Hemichorea/Hemiballism | Treatment | Outcome |
---|---|---|---|---|---|---|---|
Abe et al. [25] | M, 73 yrs | DM (not specified), hypertension | 151 mg/dL HbA1c 17.2% | Numbness in right upper and lower limbs | 2 weeks later | Haloperidol | Improvement |
Abe et al. [25] | M, 16 yrs | DM 1 | 312 mg/dL HbA1c 17.9% | Numbness in left upper and lower limbs | A month later | Haloperidol | Improvement |
Abe at al. [25] | W, 84 yrs | DM (not specified), hypertension | 107 mg/dL HbA1c 7.4% (previous 12.3%) | Transient weakness of right hand | 10 days later | Haloperidol | Improvement |
Lin, Huang [26] | M, 73 yrs | DM (not specified) | 815 mg/dL HbA1c 17.3% | Episode of non-ketotic hyperglycemia (symptoms not specified) | A month later | Haloperidol, clonazepam | Progressive resolution |
Bizet et al. [27] | W, 66 yrs | DM 2, hypertension, dyslipidemia | 984 mg/dL | Episode of non-ketotic hyperglycemia (symptoms not specified) | 3 months later | Risperidone | Resolution |
Aguiar et al. [28] | W, 69 yrs | DM (not specified) | Not available | Episode of non-ketotic hyperglycemia (symptoms not specified) | 2 weeks later | Not available | Not available |
Lim et al. [29] | W, 70 yrs | DM 2 | 46 mmol/L HbA1c 16.3% | Lethargy and confusion | 2 weeks later | Tetrabenazine | Improvement |
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Sperotto, R.; Ceccarelli, L.; Tereshko, Y.; Merlino, G.; Gigli, G.L.; Valente, M. The Possible Precipitating Role of SARS-CoV-2 in a Case of Late-Onset Hemichorea Due to a Hyperosmolar Hyperglycemic State: Case Report and Brief Literature Review. Medicina 2023, 59, 1949. https://doi.org/10.3390/medicina59111949
Sperotto R, Ceccarelli L, Tereshko Y, Merlino G, Gigli GL, Valente M. The Possible Precipitating Role of SARS-CoV-2 in a Case of Late-Onset Hemichorea Due to a Hyperosmolar Hyperglycemic State: Case Report and Brief Literature Review. Medicina. 2023; 59(11):1949. https://doi.org/10.3390/medicina59111949
Chicago/Turabian StyleSperotto, Roberto, Laura Ceccarelli, Yan Tereshko, Giovanni Merlino, Gian Luigi Gigli, and Mariarosaria Valente. 2023. "The Possible Precipitating Role of SARS-CoV-2 in a Case of Late-Onset Hemichorea Due to a Hyperosmolar Hyperglycemic State: Case Report and Brief Literature Review" Medicina 59, no. 11: 1949. https://doi.org/10.3390/medicina59111949