Frequency Mixing Magnetic Detection Setup Employing Permanent Ring Magnets as a Static Offset Field Source
Abstract
:1. Introduction
2. Materials and Methods
2.1. Frequency Mixing Magnetic Detection (FMMD)
2.2. Experimental Setup
2.2.1. Magnetic Reader
2.2.2. Electromagnet Offset Module (EMOM)
2.2.3. FEM Simulations of PMOM Configuration
2.2.4. Measurement Head Design with Permanent Magnet
2.3. Magnetic Nanoparticles
3. Results and Discussion
3.1. Simulation Results
3.2. Measurement Head Excitation and Static Offset Field Characterization
3.3. Static Offset Dependant Measurement Signal
3.4. Sensitivity Comparison
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Chen, Y.-T.; Kolhatkar, A.G.; Zenasni, O.; Xu, S.; Lee, T.R. Biosensing Using Magnetic Particle Detection Techniques. Sensors 2017, 17, 2300. [Google Scholar] [CrossRef]
- Rezvani Jalal, N.; Mehrbod, P.; Shojaei, S.; Labouta, H.I.; Mokarram, P.; Afkhami, A.; Madrakian, T.; Los, M.J.; Schaafsma, D.; Giersig, M.; et al. Magnetic Nanomaterials in Microfluidic Sensors for Virus Detection: A Review. ACS Appl. Nano Mater. 2021, 4, 4307–4328. [Google Scholar] [CrossRef]
- Ali, A.; Shah, T.; Ullah, R.; Zhou, P.; Guo, M.; Ovais, M.; Tan, Z.; Rui, Y. Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications. Front. Chem. 2021, 9, 629054. [Google Scholar] [CrossRef]
- Herynek, V.; Babič, M.; Kaman, O.; Charvátová, H.; Veselá, M.; Šefc, L. Development of Novel Nanoparticles for MPI. Int. J. Magn. Part. Imaging 2020, 6, 2009019. [Google Scholar] [CrossRef]
- AbouSeada, N.; Ahmed, M.A.; Elmahgary, M.G. Synthesis and Characterization of Novel Magnetic Nanoparticles for Photocatalytic Degradation of Indigo Carmine Dye. Mater. Sci. Energy Technol. 2022, 5, 116–124. [Google Scholar] [CrossRef]
- Hedayatnasab, Z.; Abnisa, F.; Daud, W.M.A.W. Review on Magnetic Nanoparticles for Magnetic Nanofluid Hyperthermia Application. Mater. Des. 2017, 123, 174–196. [Google Scholar] [CrossRef]
- Engelmann, U.M.; Roeth, A.A.; Eberbeck, D.; Buhl, E.M.; Neumann, U.P.; Schmitz-Rode, T.; Slabu, I. Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells. Sci. Rep. 2018, 8, 13210. [Google Scholar] [CrossRef] [Green Version]
- Fabris, F.; Lima, E.; De Biasi, E.; Troiani, H.E.; Vásquez Mansilla, M.; Torres, T.E.; Fernández Pacheco, R.; Ibarra, M.R.; Goya, G.F.; Zysler, R.D.; et al. Controlling the Dominant Magnetic Relaxation Mechanisms for Magnetic Hyperthermia in Bimagnetic Core–Shell Nanoparticles. Nanoscale 2019, 11, 3164–3172. [Google Scholar] [CrossRef] [PubMed]
- Engelmann, U.M.; Fitter, J.L.; Baumann, M. Assessing Magnetic Fluid Hyperthermia: Magnetic Relaxation Simulation, Modeling of Nanoparticle Uptake inside Pancreatic Tumor Cells and in Vitro Efficacy; Infinite Science Publishing: Hingham, MA, USA, 2019. [Google Scholar]
- Rytov, R.A.; Bautin, V.A.; Usov, N.A. Towards Optimal Thermal Distribution in Magnetic Hyperthermia. Sci. Rep. 2022, 12, 3023. [Google Scholar] [CrossRef]
- Buzug, T.M.; Borgert, J. Magnetic Particle Imaging: A Novel SPIO Nanoparticle Imaging Technique. In Springer Proceedings in Physics; Springer: Berlin/Heidelberg, Germany, 2012; ISBN 978-3-642-24132-1. [Google Scholar]
- Mattern, A.; Sandig, R.; Joos, A.; Löwa, N.; Kosch, O.; Weidner, A.; Wells, J.; Wiekhorst, F.; Dutz, S. Magnetic Nanoparticle-Gel Materials for Development of MPI and MRI Phantoms. Int. J. Magn. Part. Imaging 2018, 4, 1811001. [Google Scholar] [CrossRef]
- Le, T.-A.; Zhang, X.; Hoshiar, A.K.; Yoon, J. Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery. Sensors 2017, 17, 2050. [Google Scholar] [CrossRef] [Green Version]
- Guigou, C.; Lalande, A.; Millot, N.; Belharet, K.; Grayeli, A.B. Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges. Brain Sci. 2021, 11, 358. [Google Scholar] [CrossRef] [PubMed]
- Nieciecka, D.; Rękorajska, A.; Cichy, D.; Końska, P.; Żuk, M.; Krysiński, P. Synthesis and Characterization of Magnetic Drug Carriers Modified with Tb3+ Ions. Nanomaterials 2022, 12, 795. [Google Scholar] [CrossRef] [PubMed]
- Mehrafrooz, B.; Pedram, M.Z.; Ghafar-Zadeh, E. An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane. Sensors 2018, 18, 381. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Guo, R.; Wang, S.; Huang, F.; Chen, Q.; Li, Y.; Liao, M.; Lin, J. Rapid Detection of Salmonella Typhimurium Using Magnetic Nanoparticle Immunoseparation, Nanocluster Signal Amplification and Smartphone Image Analysis. Sens. Actuators B Chem. 2019, 284, 134–139. [Google Scholar] [CrossRef]
- Wu, K.; Liu, J.; Saha, R.; Su, D.; Krishna, V.D.; Cheeran, M.C.-J.; Wang, J.-P. Magnetic Particle Spectroscopy for Detection of Influenza A Virus Subtype H1N1. ACS Appl. Mater. Interfaces 2020, 12, 13686–13697. [Google Scholar] [CrossRef]
- Chung, H.J.; Castro, C.M.; Im, H.; Lee, H.; Weissleder, R. A Magneto-DNA Nanoparticle System for Rapid Detection and Phenotyping of Bacteria. Nat Nanotechnol 2013, 8, 369–375. [Google Scholar] [CrossRef] [Green Version]
- Liu, P.; Jonkheijm, P.; Terstappen, L.W.M.M.; Stevens, M. Magnetic Particles for CTC Enrichment. Cancers 2020, 12, 3525. [Google Scholar] [CrossRef]
- Jyoti, D.; Gordon-Wylie, S.W.; Reeves, D.B.; Paulsen, K.D.; Weaver, J.B. Distinguishing Nanoparticle Aggregation from Viscosity Changes in MPS/MSB Detection of Biomarkers. Sensors 2022, 22, 6690. [Google Scholar] [CrossRef]
- Lim, J.; Yeap, S.P.; Che, H.X.; Low, S.C. Characterization of Magnetic Nanoparticle by Dynamic Light Scattering. Nanoscale Res. Lett. 2013, 8, 381. [Google Scholar] [CrossRef]
- Garraud, N.; Dhavalikar, R.; Unni, M.; Savliwala, S.; Rinaldi, C.; Arnold, D.P. Benchtop Magnetic Particle Relaxometer for Detection, Characterization and Analysis of Magnetic Nanoparticles. Phys. Med. Biol. 2018, 63, 175016. [Google Scholar] [CrossRef] [PubMed]
- Pourshahidi, A.M.; Engelmann, U.M.; Offenhäusser, A.; Krause, H.J. Resolving Ambiguities in Core Size Determination of Magnetic Nanoparticles from Magnetic Frequency Mixing Data. J. Magn. Magn. Mater. 2022, 563, 169969. [Google Scholar] [CrossRef]
- Engelmann, U.M.; Pourshahidi, A.M.; Shalaby, A.; Krause, H.J. Probing Particle Size Dependency of Frequency Mixing Magnetic Detection with Dynamic Relaxation Simulation. J. Magn. Magn. Mater. 2022, 563, 169969. [Google Scholar] [CrossRef]
- Ludwig, F.; Guillaume, A.; Schilling, M.; Frickel, N.; Schmidt, A.M. Determination of Core and Hydrodynamic Size Distributions of CoFe2O4 Nanoparticle Suspensions Using Ac Susceptibility Measurements. J. Appl. Phys. 2010, 108, 033918. [Google Scholar] [CrossRef]
- Krause, H.-J.; Wolters, N.; Zhang, Y.; Offenhäusser, A.; Miethe, P.; Meyer, M.H.F.; Hartmann, M.; Keusgen, M. Magnetic Particle Detection by Frequency Mixing for Immunoassay Applications. J. Magn. Magn. Mater. 2007, 311, 436–444. [Google Scholar] [CrossRef]
- Pietschmann, J.; Dittmann, D.; Spiegel, H.; Krause, H.-J.; Schröper, F. A Novel Method for Antibiotic Detection in Milk Based on Competitive Magnetic Immunodetection. Foods 2020, 9, 1773. [Google Scholar] [CrossRef] [PubMed]
- Pietschmann, J.; Spiegel, H.; Krause, H.-J.; Schillberg, S.; Schröper, F. Sensitive Aflatoxin B1 Detection Using Nanoparticle-Based Competitive Magnetic Immunodetection. Toxins 2020, 12, 337. [Google Scholar] [CrossRef]
- Achtsnicht, S.; Neuendorf, C.; Faßbender, T.; Nölke, G.; Offenhäusser, A.; Krause, H.-J.; Schröper, F. Sensitive and Rapid Detection of Cholera Toxin Subunit B Using Magnetic Frequency Mixing Detection. PLoS ONE 2019, 14, e0219356. [Google Scholar] [CrossRef]
- Meyer, M.H.F.; Hartmann, M.; Krause, H.-J.; Blankenstein, G.; Mueller-Chorus, B.; Oster, J.; Miethe, P.; Keusgen, M. CRP Determination Based on a Novel Magnetic Biosensor. Biosens. Bioelectron. 2007, 22, 973–979. [Google Scholar] [CrossRef]
- Meyer, M.H.F.; Krause, H.-J.; Hartmann, M.; Miethe, P.; Oster, J.; Keusgen, M. Francisella Tularensis Detection Using Magnetic Labels and a Magnetic Biosensor Based on Frequency Mixing. J. Magn. Magn. Mater. 2007, 311, 259–263. [Google Scholar] [CrossRef]
- Rettcher, S.; Jungk, F.; Kühn, C.; Krause, H.-J.; Nölke, G.; Commandeur, U.; Fischer, R.; Schillberg, S.; Schröper, F. Simple and Portable Magnetic Immunoassay for Rapid Detection and Sensitive Quantification of Plant Viruses. Appl. Environ. Microbiol. 2015, 81, 3039–3048. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hong, H.-B. Detection of Two Different Influenza A Viruses Using a Nitrocellulose Membrane and a Magnetic Biosensor. J. Immunol. Methods 2011, 365, 95–100. [Google Scholar] [CrossRef]
- Pourshahidi, A.M.; Achtsnicht, S.; Nambipareechee, M.M.; Offenhäusser, A.; Krause, H.-J. Multiplex Detection of Magnetic Beads Using Offset Field Dependent Frequency Mixing Magnetic Detection. Sensors 2021, 21, 5859. [Google Scholar] [CrossRef] [PubMed]
- Engelmann, U.M.; Shalaby, A.; Shasha, C.; Krishnan, K.M.; Krause, H.-J. Comparative Modeling of Frequency Mixing Measurements of Magnetic Nanoparticles Using Micromagnetic Simulations and Langevin Theory. Nanomaterials 2021, 11, 1257. [Google Scholar] [CrossRef]
- Achtsnicht, S.; Pourshahidi, A.M.; Offenhäusser, A.; Krause, H.-J. Multiplex Detection of Different Magnetic Beads Using Frequency Scanning in Magnetic Frequency Mixing Technique. Sensors 2019, 19, 2599. [Google Scholar] [CrossRef] [PubMed]
- What Does Y35 Stand for?—Supermagnete.De. Available online: https://www.supermagnete.de/eng/faq/What-does-Y35-stand-for (accessed on 27 September 2022).
Region | Temperature [°C] | Nonlinear Magnetic Moment Amplitude [nAm2] | ||||
---|---|---|---|---|---|---|
EMOM-Pulsed | EMOM-Cont. | PMOM | EMOM-Pulsed | EMOM-Cont. | PMOM | |
a | 43.75 | 44.31 | 39.00 | 34.16 | 32.84 | 33.73 |
b | 46.37 | 52.10 | 38.60 | 101.03 | 104.07 | 103.03 |
c | 50.62 | 69.90 | 38.25 | 67.56 | 62.97 | 67.83 |
d | 51.60 | 74.56 | 38.50 | 59.41 | 54.33 | 62.714 |
Mixing term | Feature | Syn70-EMOM Feature Location [mT] | Syn70-PMOM Feature Location [mT] | Difference [%] |
---|---|---|---|---|
f1 + f2 | Maximum | 15.06 | 14.95 | 0.73 |
f1 + 2·f2 | Zero | 12.03 | 12.2 | 1.41 |
Minimum | 16.13 | 16.36 | 1.42 | |
f1 + 3·f2 | Maximum | 8.35 | 8.41 | 0.71 |
Zero | 14.60 | 14.83 | 1.5 | |
Minimum | 16.56 | 16.80 | 1.4 | |
f1 + 4·f2 | 1st Zero | 6.57 | 6.65 | 1.2 |
Minimum | 11.54 | 11.52 | 0.17 | |
2nd Zero | 15.57 | 15.63 | 0.38 | |
Maximum | 16.99 | 17.11 | 0.70 |
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Pourshahidi, A.M.; Achtsnicht, S.; Offenhäusser, A.; Krause, H.-J. Frequency Mixing Magnetic Detection Setup Employing Permanent Ring Magnets as a Static Offset Field Source. Sensors 2022, 22, 8776. https://doi.org/10.3390/s22228776
Pourshahidi AM, Achtsnicht S, Offenhäusser A, Krause H-J. Frequency Mixing Magnetic Detection Setup Employing Permanent Ring Magnets as a Static Offset Field Source. Sensors. 2022; 22(22):8776. https://doi.org/10.3390/s22228776
Chicago/Turabian StylePourshahidi, Ali Mohammad, Stefan Achtsnicht, Andreas Offenhäusser, and Hans-Joachim Krause. 2022. "Frequency Mixing Magnetic Detection Setup Employing Permanent Ring Magnets as a Static Offset Field Source" Sensors 22, no. 22: 8776. https://doi.org/10.3390/s22228776