Next Article in Journal
Transportin-3 Facilitates Uncoating of Influenza A Virus
Next Article in Special Issue
Unraveling the Immune Microenvironment of Thymic Epithelial Tumors: Implications for Autoimmunity and Treatment
Previous Article in Journal
The Characters of Non-Coding RNAs and Their Biological Roles in Plant Development and Abiotic Stress Response
Previous Article in Special Issue
Thymic Epithelial Neoplasms: Focusing on the Epigenetic Alterations
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 8
10.3390/ijms23084125
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Clinical and Molecular Insights of Radiation-Induced Breast Sarcomas: Is There Hope on the Horizon for Effective Treatment of This Aggressive Disease?

Int. J. Mol. Sci. 2022, 23(8), 4125; https://doi.org/10.3390/ijms23084125
by Stefania Kokkali 1,2,*, Jose Duran Moreno 3, Jerzy Klijanienko 4 and Stamatios Theocharis 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2022, 23(8), 4125; https://doi.org/10.3390/ijms23084125
Submission received: 3 March 2022 / Revised: 31 March 2022 / Accepted: 1 April 2022 / Published: 8 April 2022
(This article belongs to the Special Issue Molecular Advances in Cancer Therapy)

Round 1

Reviewer 1 Report

The review article “Clinical and molecular insights of radiation-induced breast sarcomas: is there hope on the horizon for effective treatment of this aggressive disease?” is well-structured and covers a low incident but relevant topic. The clinical and histopathological characteristics of RIBS are discussed, as well as their management and prognosis, emphasizing their distinct characteristics versus primary breast sarcomas.

Some minor general points to be addressed:

The references cover the last 20 years (or more). Authors should review if references older than 2000 are needed.

Figure 2 is allowed to be published? Is any ethical letter needed? The X-axis lacks legend. The red blood should be removed. The numbers within the circles are not clear.  The image quality should be 300 dpi.

The atypical vascular lesion (AVL), should be defined the first time appearing.

The abstract does not cover the content of the manuscript.

 

 

 

Author Response

Thank you very much for your time reviewing this manuscript and your comments. We replied to all of them and modified the manuscript accordinlgy.

Author Response File: Author Response.doc

Reviewer 2 Report

Kokkali et al. comprehensively review the scientific literature surrounding radiation-induced breast sarcomas and discuss the effectiveness of potential treatments for RIBS. Overall, the review is well organized and thorough. I have minor comments that should be addressed before this review is accepted for publication. 

  1. Bars must be included in both images in Figure 2.
  2. In section 3 where the authors discuss RIBS in BRCA-mutation carriers, a brief statement should be added on the function of BRCA proteins in genomic instability and potential concerns regarding the use of radiotherapy in these patients. Similar changes should be included when discussing P53 mutations in Li-Fraumeni syndrome and other genetic alterations. 
  3. PTEN mutations occur at a high frequency in breast cancer patients. Is there a link between PTEN and RIBS? 

Author Response

Thank you very much for your time reviewing this manuscript and your comments. All your points are answered in the attached document and modifications were made accordingly in the manuscript.

Author Response File: Author Response.doc

Back to TopTop