Topic Editors

Dr. Marco D'Arienzo
Health and Medical Sciences and Medical Physics Department, Saint Camillus International University, ASL Roma 6, Rome, Italy
Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
Dr. Gian Marco Contessa
Italian National Institute of Health, 00161 Rome, Italy

Ionizing and Non-ionizing Radiation: Advances in Healthcare, Environmental Safety and Occupational Radiation Protection

Abstract submission deadline
31 August 2024
Manuscript submission deadline
31 October 2024
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Topic Information

Dear Colleagues,

Recent decades have seen a dramatic acceleration in the development and adoption of new technologies using both ionizing and non-ionizing radiation.

Non-ionizing radiation is commonly used in healthcare applications such as laser surgery, endoscopy, UV light therapies, as well as magnetic resonance imaging. In addition, mobile telecommunication technologies transmit and receive electromagnetic fields that allow communication to occur. In particular, the scientific community has become increasingly interested in the exposure caused by 5G infrastructures over the past few years.

The use of ionizing radiation in healthcare has grown worldwide. The major advances of ionizing radiation in healthcare have led to groundbreaking innovations and improved patient care. In particular, radiation therapy has witnessed remarkable advances over the years, significantly transforming cancer treatment. As technology continues to advance, radiation therapy will likely play an increasingly central role in the comprehensive approach to cancer care, offering hope and improved prospects for patients worldwide.

Ionizing radiations also find applications in pharmacology, contributing to drug development and quality control. Radiolabeling techniques help researchers trace drug distribution and metabolism in vivo, facilitating a deeper understanding of pharmacokinetics. Furthermore, radiations are employed in sterilization processes to ensure the safety and sterility of medical devices and pharmaceutical products, safeguarding patient health.

Ultimately, the potential for CBRNe events (chemical, biological, radiological, nuclear, and explosive) to cause significant harm to human health and the environment is a critical concern for governments, emergency responders, and the public alike.  Radiological risks in CBRN events arise primarily from the malevolent use of a radiation source or unauthorized/accidental release of radioactive materials, such as those used in medical, industrial, or nuclear applications. As radiological risks continue to evolve, continuous research, innovation, and vigilance remain essential in countering CBRNe events effectively.

The purpose of this Topic is to bring together state-of-the-art achievements, developments, and advances on all aspects of ionizing and non-ionizing radiation and serve as a platform for colleagues to exchange novel ideas in this area.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). We encourage authors to submit original research articles and reviews on (but not limited to) the following topics:

  • Medical applications of ionizing and non-ionizing radiation;
  • Recent developments in the use of radiation in healthcare;
  • Ionizing radiation in pharmacology;
  • Radiation, health effects and protective measures;
  • Radiation dosimetry;
  • Radiation protection;
  • Advances in radiation oncology;
  • Recent advances in molecular radiotherapy;
  • Biological effects of radiation;
  • Radiological and nuclear safety;
  • CBRNe threats;
  • Radiological hazards in CBRNe events;
  • Medical radiation countermeasures for nuclear and radiological emergencies;
  • Non-Ionizing radiation safety;
  • Non-ionizing radiation in healthcare;
  • Environmental radioactivity;
  • Radon in the environment;
  • Cosmic radiation and cosmogenic radionuclides.

In this Topic, we are looking for submissions mainly dealing with recent advances and developments in the application of ionizing and non-ionizing radiation.

Dr. Marco D'Arienzo
Dr. Andrea Malizia
Dr. Gian Marco Contessa
Topic Editors


  • ionizing radiation
  • non-ionizing radiation
  • radiation dosimetry
  • radiation protection
  • environmental radioactivity
  • radiation therapy
  • radiation safety
  • cancer radiotherapy
  • radiobiology
  • radiological threats

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
5.2 7.4 2009 17.9 Days CHF 2900 Submit
3.6 3.6 2011 20.7 Days CHF 2600 Submit
International Journal of Molecular Sciences
5.6 7.8 2000 16.3 Days CHF 2900 Submit
- - 2021 24.5 Days CHF 1000 Submit
1.9 3.3 2015 29.6 Days CHF 1800 Submit
2.8 2.7 2013 19.5 Days CHF 2700 Submit is a multidiscipline platform providing preprint service that is dedicated to sharing your research from the start and empowering your research journey.

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Published Papers (1 paper)

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13 pages, 1439 KiB  
Proton Treatment Suppresses Exosome Production in Head and Neck Squamous Cell Carcinoma
Cancers 2024, 16(5), 1008; - 29 Feb 2024
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Proton therapy (PT) is emerging as an effective and less toxic alternative to conventional X-ray-based photon therapy (XRT) for patients with advanced head and neck squamous cell carcinomas (HNSCCs) owing to its clustered dose deposition dosimetric characteristics. For optimal efficacy, cancer therapies, including [...] Read more.
Proton therapy (PT) is emerging as an effective and less toxic alternative to conventional X-ray-based photon therapy (XRT) for patients with advanced head and neck squamous cell carcinomas (HNSCCs) owing to its clustered dose deposition dosimetric characteristics. For optimal efficacy, cancer therapies, including PT, must elicit a robust anti-tumor response by effector and cytotoxic immune cells in the tumor microenvironment (TME). While tumor-derived exosomes contribute to immune cell suppression in the TME, information on the effects of PT on exosomes and anti-tumor immune responses in HNSCC is not known. In this study, we generated primary HNSCC cells from tumors resected from HNSCC patients, irradiated them with 5 Gy PT or XRT, and isolated exosomes from cell culture supernatants. HNSCC cells exposed to PT produced 75% fewer exosomes than XRT- and non-irradiated HNSCC cells. This effect persisted in proton-irradiated cells for up to five days. Furthermore, we observed that exosomes from proton-irradiated cells were identical in morphology and immunosuppressive effects (suppression of IFN-γ release by peripheral blood mononuclear cells) to those of photon-irradiated cells. Our results suggest that PT limits the suppressive effect of exosomes on cancer immune surveillance by reducing the production of exosomes that can inhibit immune cell function. Full article
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