Microbial Antigen Delivery

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: closed (31 July 2018) | Viewed by 9443

Special Issue Editor

Department of Microbiology and Immunology, Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
Interests: extremophiles; haloarchaea; microbial genomics; purple membrane; gas vesicle nanoparticles; vaccines and therapeutics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Many strategies are currently being developed to expand the repertoire of preventative and therapeutic vaccines against a variety of diseases. Diverse microbial systems are being utilized, from Archaea to Bacteria, Fungi, and Viruses, which offer advantages over traditional vaccines. Notable among them are recombinant vectors, liposomes and nanoparticles, and other customizable delivery vehicles that are designed to increase immunogenicity and efficacy, while reducing toxicity and adverse effects. Compared to live-attenuated, inactivated or killed pathogens, microbial antigen delivery systems may offer greater safety, increased stability, optimized presentation, enhanced adjuvant effect, and improved immunogenicity, potentially reducing the immunization and dosage requirements. They hold the promise of eliciting a full adaptive immune response as well as long-term systemic humoral and cell-mediated immunity. As a result, microbial antigen delivery systems may help cure some of the most widespread and pervasive as well as rare and orphaned diseases. Of particular importance in the 21st century are emerging and re-emerging infectious diseases, long-standing tropical infectious diseases, and hematological malignancies and solid tumors. This special issue of Vaccines will cover topics relevant to new and developing systems for microbial antigen delivery.

Prof. Dr. Shiladitya DasSarma
Guest Editor

Manuscript Submission Information

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  • expression systems
  • customizable delivery vehicles
  • adjuvant effects
  • immunogenicity
  • therapeutic vaccines
  • cancer vaccines

Published Papers (1 paper)

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Newcastle Disease Virus Vectored Bivalent Vaccine against Virulent Infectious Bursal Disease and Newcastle Disease of Chickens
Vaccines 2017, 5(4), 31; https://doi.org/10.3390/vaccines5040031 - 26 Sep 2017
Cited by 19 | Viewed by 8993
Newcastle disease virus (NDV) strain F is a lentogenic vaccine strain used for primary vaccination in day-old chickens against Newcastle disease (ND) in India and Southeast Asian countries. Recombinant NDV-F virus and another recombinant NDV harboring the major capsid protein VP2 gene of [...] Read more.
Newcastle disease virus (NDV) strain F is a lentogenic vaccine strain used for primary vaccination in day-old chickens against Newcastle disease (ND) in India and Southeast Asian countries. Recombinant NDV-F virus and another recombinant NDV harboring the major capsid protein VP2 gene of a very virulent infectious bursal disease virus (IBDV); namely rNDV-F and rNDV-F/VP2, respectively, were generated using the NDV F strain. The rNDV-F/VP2 virus was slightly attenuated, as compared to the rNDV-F virus, as evidenced from the mean death time and intracerebral pathogenicity index analysis. This result indicates that rNDV-F/VP2 behaves as a lentogenic virus and it is stable even after 10 serial passages in embryonated chicken eggs. When chickens were vaccinated with the rNDV F/VP2, it induced both humoral and cell mediated immunity, and was able to confer complete protection against very virulent IBDV challenge and 80% protection against virulent NDV challenge. These results suggest that rNDV-F could be an effective and inherently safe vaccine vector. Here, we demonstrate that a bivalent NDV-IBDV vaccine candidate generated by reverse genetics method is safe, efficacious and cost-effective, which will greatly aid the poultry industry in developing countries. Full article
(This article belongs to the Special Issue Microbial Antigen Delivery)
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