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Vaccines
Special Issues
Basic Virological Aspects of SARS-CoV-2
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Basic Virological Aspects of SARS-CoV-2

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2382

Special Issue Editors

Dr. Andreu Comas-Garcia

E-Mail Website
Guest Editor
Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico
Interests: respiratory viruses; virology; epidemiology; vaccines; viral evolution
Dr. Sofía Bernal-Silva

E-Mail Website
Guest Editor
Deprtamento de Microbiología y Centro de Investigación en Ciencias de la Salud y Biomedicina, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico
Interests: respiratory viruses; virology; epidemiology; HPV; CMV
Prof. Dr. S. Louise Cosby

E-Mail Website
Guest Editor
1. School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast BT9 7BL, UK
2. Virology, Veterinary Sciences Division, Agri-Food and Biosciences Institute, Belfast BT4 3SD, UK
Interests: pathogenic mechanisms of RNA viruses (morbilliviruses, respiratory syncytial virus, coronavirus); recombinant vaccine design; genetic markers of virus susceptibility and assessment in small/large animal models; paramyxoviruses; pathogenic mechanisms of measles virus; morbilliviruses; respiratory syncytial virus; coronavirus; vaccine design; vaccination
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

SARS-CoV-2 is a virus that has completely changed our world in the three years since it first emerged. Indeed, the COVID-19 pandemic generated a new challenge to obtain high-quality information in a short period of time. This new information required about SARS-CoV-2 needed to be focused on understanding the physiopathology of the COVID-19 disease, identifying biomarkers, and designing a vaccine and treatments. The scope of this Special Issue is to gather information about the basic virology aspects of SARS-CoV-2 and their impact on the design of vaccines and/or drugs. Further, the basic virology aspect can be focused on to understand the physiopathology of COVID-19 disease. 

Before the COVID-19 pandemic, SARS viruses had a relative slow evolution rate. However, globalization, unequal strategies to control or mitigate the pandemic around the world, and the generation of several vaccines increased the evolution rate. This evolution, centered in the scape of the immune system, had a great impact on the persistence of the pandemic and a critical decrease in vaccines’ effectiveness. Therefore, understanding the basic virological aspect of this virus through high-quality information will allow us to generate better strategies against this virus.

Dr. Andreu Comas-Garcia
Dr. Sofía Bernal-Silva
Prof. Dr. S. Louise Cosby
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • SARS-CoV-2
  • molecular virology
  • vaccines
  • evolution
  • molecular mechanism

Published Papers (1 paper)

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Research

16 pages, 6444 KiB  
Article
Incipient Parallel Evolution of SARS-CoV-2 Deltacron Variant in South Brazil
by Fernando Hayashi Sant’Anna, Tiago Finger Andreis, Richard Steiner Salvato, Ana Paula Muterle Varela, Juliana Comerlato, Tatiana Schäffer Gregianini, Regina Bones Barcellos, Fernanda Marques de Souza Godinho, Paola Cristina Resende, Gabriel da Luz Wallau, Thaís Regina y Castro, Bruna Campestrini Casarin, Andressa de Almeida Vieira, Alexandre Vargas Schwarzbold, Priscila de Arruda Trindade, Gabriela Luchiari Tumioto Giannini, Luana Freese, Giovana Bristot, Carolina Serpa Brasil, Bruna de Oliveira Rocha, Paloma Bortolini Martins, Francine Hehn de Oliveira, Cock van Oosterhout and Eliana Wendlandadd Show full author list remove Hide full author list
Vaccines 2023, 11(2), 212; https://doi.org/10.3390/vaccines11020212 - 18 Jan 2023
Cited by 1 | Viewed by 1920
Abstract
With the coexistence of multiple lineages and increased international travel, recombination and gene flow are likely to become increasingly important in the adaptive evolution of SARS-CoV-2. These processes could result in genetic introgression and the incipient parallel evolution of multiple recombinant lineages. However, [...] Read more.
With the coexistence of multiple lineages and increased international travel, recombination and gene flow are likely to become increasingly important in the adaptive evolution of SARS-CoV-2. These processes could result in genetic introgression and the incipient parallel evolution of multiple recombinant lineages. However, identifying recombinant lineages is challenging, and the true extent of recombinant evolution in SARS-CoV-2 may be underestimated. This study describes the first SARS-CoV-2 Deltacron recombinant case identified in Brazil. We demonstrate that the recombination breakpoint is at the beginning of the Spike gene. The 5′ genome portion (circa 22 kb) resembles the AY.101 (Delta), and the 3′ genome portion (circa 8 kb nucleotides) is most similar to the BA.1.1 (Omicron). Furthermore, evolutionary genomic analyses indicate that the new strain emerged after a single recombination event between lineages of diverse geographical locations in December 2021 in South Brazil. This Deltacron, AYBA-RS, is one of the dozens of recombinants described in 2022. The submission of only four sequences in the GISAID database suggests that this lineage had a minor epidemiological impact. However, the recent emergence of this and other Deltacron recombinant lineages (XD, XF, and XS) suggests that gene flow and recombination may play an increasingly important role in the COVID-19 pandemic. We explain the evolutionary and population genetic theory that supports this assertion, concluding that this stresses the need for continued genomic surveillance. This monitoring is vital for countries where multiple variants are present, as well as for countries that receive significant inbound international travel. Full article
(This article belongs to the Special Issue Basic Virological Aspects of SARS-CoV-2)
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