Vaccination against Infectious Diseases in Livestock

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Infectious Diseases".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1650

Special Issue Editors


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Guest Editor
Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA
Interests: vaccine development; adjuvants; dendritic cells; influenza; immunopathology

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Guest Editor
Department of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, IA, USA
Interests: vaccine development; bovine immunology; bovine respiratory disease; mucosal immunity; innate immune memory

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Guest Editor
Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania
Interests: immunology; immunopathology; vaccines; infectious diseases; zoonotic diseases

Special Issue Information

Dear Colleagues,

Livestock are a major source of protein needed to feed a growing global population and are important for the livelihood of many people in lower and middle-income countries. Vaccination is a critical strategy for the control of infectious diseases that threaten the health and well-being of food animals. Vaccination of livestock is also a major One Health issue as it helps to prevent the spread of zoonotic diseases and is a tool to reduce the use of antibiotics. This special issue of Vaccines explores recent advances in the development of vaccines for livestock and highlights new vaccine technologies, the application of nanotechnology in the delivery and formulation of vaccines, and the use of alternative routes of vaccination through a combination of original papers and reviews. A special emphasis is placed on diseases of zoonotic and economic importance.     

Prof. Dr. Harm HogenEsch
Dr. Jodi McGill
Prof. Dr. Joram Buza
Guest Editors

Manuscript Submission Information

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Keywords

  • vaccines
  • vaccination
  • mucosal vaccination
  • nanoparticles
  • adjuvants
  • zoonoses
  • cattle
  • sheep
  • goats
  • swine
  • poultry
  • aquaculture

Published Papers (1 paper)

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Research

17 pages, 3660 KiB  
Article
Intradermal Vaccination against Influenza with a STING-Targeted Nanoparticle Combination Adjuvant Induces Superior Cross-Protective Humoral Immunity in Swine Compared with Intranasal and Intramuscular Immunization
by Juan F. Hernandez-Franco, Ganesh Yadagiri, Veerupaxagouda Patil, Dina Bugybayeva, Sara Dolatyabi, Ekachai Dumkliang, Mithilesh Singh, Raksha Suresh, Fatema Akter, Jennifer Schrock, Gourapura J. Renukaradhya and Harm HogenEsch
Vaccines 2023, 11(11), 1699; https://doi.org/10.3390/vaccines11111699 - 07 Nov 2023
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Abstract
The development of cross-protective vaccines against the zoonotic swine influenza A virus (swIAV), a potential pandemic-causing agent, continues to be an urgent global health concern. Commercially available vaccines provide suboptimal cross-protection against circulating subtypes of swIAV, which can lead to worldwide economic losses [...] Read more.
The development of cross-protective vaccines against the zoonotic swine influenza A virus (swIAV), a potential pandemic-causing agent, continues to be an urgent global health concern. Commercially available vaccines provide suboptimal cross-protection against circulating subtypes of swIAV, which can lead to worldwide economic losses and poor zoonosis deterrence. The limited efficacy of current swIAV vaccines demands innovative strategies for the development of next-generation vaccines. Considering that intramuscular injection is the standard route of vaccine administration in both human and veterinary medicine, the exploration of alternative strategies, such as intradermal vaccination, presents a promising avenue for vaccinology. This investigation demonstrates the first evaluation of a direct comparison between a commercially available multivalent swIAV vaccine and monovalent whole inactivated H1N2 swine influenza vaccine, delivered by intradermal, intranasal, and intramuscular routes. The monovalent vaccines were adjuvanted with NanoST, a cationic phytoglycogen-based nanoparticle that is combined with the STING agonist ADU-S100. Upon heterologous challenge, intradermal vaccination generated a stronger cross-reactive nasal and serum antibody response in pigs compared with intranasal and intramuscular vaccination. Antibodies induced by intradermal immunization also had higher avidity compared with the other routes of vaccination. Bone marrow from intradermally and intramuscularly immunized pigs had both IgG and IgA virus-specific antibody-secreting cells. These studies reveal that NanoST is a promising adjuvant system for the intradermal administration of STING-targeted influenza vaccines. Full article
(This article belongs to the Special Issue Vaccination against Infectious Diseases in Livestock)
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