Special Issue "Neutrophils and Host Immunity"
Deadline for manuscript submissions: 31 March 2024 | Viewed by 11391
Interests: neutrophils biology; influenza virus infection; bacterial pneumonia; host-pathogen interaction; sepsis; acute respiratory distress syndrome (ARDS); immunosenescence; obesity; antimicrobial peptides
Interests: host-pathogen interactions; bacterial pathogenesis; neutrophil biology; innate and adaptive immune responses; vaccine response; lung infections; immunosenescence and pneumonia
Recent years have seen a surge in research focusing on Neutrophils as one of the central key players in orchestrating both, the innate and adaptive host immune response. Given their vast array of effector functions, these cells are required for the host defense and are traditionally known as “first responders” to reach the site of infection or inflammation. Not only do they kill and clear invading pathogens through different antimicrobial functions, including recently discovered neutrophils extracellular traps (NETs) formation, but also play a critical role in tissue homeostasis and regeneration following inflammation. Apart from their role in innate immunity, neutrophils have recently been acknowledged to play an important role in shaping host adaptive immune response to infectious agents and vaccines. However, dysregulated neutrophil responses can trigger significantly host pathology and autoimmune disease. With the emerging knowledge in neutrophil biology research, it is becoming apparent that besides the infectious agents, there are other host factors including environment-related stress, underlying co-morbidities, and Immunosenescence which impact neutrophil activity and phenotype.
This Special Issue aims to expand the current knowledge and include new contributions to the understanding of the role of neutrophils in overall host immunity. This special issue seeks to include original research articles and reviews that highlight or discover the role of neutrophils in host protection, immunopathology, autoimmune disease, shaping or modulating adaptive immunity either post-infection or in response to the vaccine, and different strategies employed by pathogens to avoid neutrophil-mediated killing. Observations of immune pathologies related to neutrophil effector functions without substantial mechanistic insight will also be considered but should be of a novel significance to the field. Novel information regarding the role of neutrophils in shaping host response to cancers are highly encouraged. Papers highlighting the effect of age or inflammation on neutrophil phenotype and its effect on host susceptibility to various infections are appreciated. Authors are also encouraged to submit relevant findings ruling out certain aspects of neutrophil functions or signaling pathways while shaping up host immune response.
We look forward to receiving your contributions.
Dr. Jitendra Kumar Tripathi
Dr. Manmeet Pal Singh Bhalla
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- neutrophil biology
- Neutrophil Extracellular traps (NETs)
- neutrophil recruitment
- pneumonia and sepsis
- immunology of infectious diseases
- innate immunity
- Reactive oxygen species
- age-associated decline in neutrophil functions
- role of neutrophils in vaccine response