Tuberculosis Vaccine Research: Inducing Immune Memory and Regulation
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: 30 April 2024 | Viewed by 1409
Special Issue Editor
2. Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
Interests: tuberculosis subunit vaccine and immune memory
Special Issue Information
Dear Colleagues,
The purpose of tuberculosis (TB) vaccine immunization is to induce long-term immunological memory that mediates protection from infection. Memory T cells would be expected to be an important correlate of immune protection against TB. It is known that following antigen stimulation, T cells are activated and develop into different subsets including effector T cells (TEFF), effector memory T cells, central memory T cells and tissue-resident memory T cells (TRM), etc. TEM, TCM and lung TRM were reported to mediate immune protection against M. tuberculosis respiratory infection in tests conducted by different labs. However, their role in vaccine-mediated immune protection is still unclear. More studies are needed to investigate the correlation between memory T cells and protection, especially in the human population. Moreover, there are many factors, including antigens and adjuvants, that play a role in the development of immune memory. The vaccination pathway and schedule also affect the development of immune memory. All these factors need to be explored to improve the protective effects of vaccine immunization for tuberculosis.
Prof. Dr. Bingdong Zhu
Guest Editor
Manuscript Submission Information
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Keywords
- tuberculosis
- vaccine
- immune memory
