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Vaccines
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Monoclonal Antibodies for Targeted Biological Treatment of Severe Asthma
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Monoclonal Antibodies for Targeted Biological Treatment of Severe Asthma

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 6276

Special Issue Editor

Dr. Corrado Pelaia

E-Mail Website
Guest Editor
Department of Health Sciences, University “Magna Græcia” of Catanzaro, Catanzaro, Italy
Interests: asthma; lung immunology; COPD and COVID-19
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Asthma is a chronic respiratory disorder consisting of usually variable bronchial obstruction and hyperresponsiveness. Several endotypes play a crucial role in the pathobiology of asthma, causing heterogeneous clinical manifestations. Within this context, many targets for biological treatment of severe asthma, such as immunoglobulins E (IgE), pro-inflammatory cytokines and their receptors, have been identified. Specifically, omalizumab (anti-IgE), mepolizumab (anti-IL-5), reslizumab (anti-IL-5), benralizumab (anti-IL-5 receptor) and dupilumab (anti-IL-4/IL-3 receptors) are available in clinical practice, providing excellent clinical and functional effects even in a real-life environment. Furthermore, other biologics that target innate cytokines, such as IL-33 and thymic stromal lymphopoietin (TSLP), are under development. The aim is implementing phenotype/endotype-specific treatments, in order to delineate a personalized therapeutic approach tailored on the patient and chosen on the basis of existing and emerging biomarkers

Dr. Corrado Pelaia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • type2-asthma
  • IgE
  • IL-5
  • IL-4
  • IL-13
  • IL-33
  • TSLP
  • monoclonal antibodies
  • personalized medicine

Published Papers (1 paper)

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Review

12 pages, 704 KiB  
Review
Biological Therapy of Severe Asthma with Dupilumab, a Dual Receptor Antagonist of Interleukins 4 and 13
by Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Giuseppe Armentaro, Cecilia Calabrese, Angela Sciacqua, Luca Gallelli and Alessandro Vatrella
Vaccines 2022, 10(6), 974; https://doi.org/10.3390/vaccines10060974 - 19 Jun 2022
Cited by 8 | Viewed by 5620
Abstract
Interleukin-4 (IL-4) and interleukin-13 (IL-13) are key cytokines involved in the pathophysiology of both immune-inflammatory and structural changes underlying type 2 asthma. IL-4 plays a pivotal role in Th2 cell polarization, immunoglobulin E (IgE) synthesis and eosinophil recruitment into the airways. IL-13 synergizes [...] Read more.
Interleukin-4 (IL-4) and interleukin-13 (IL-13) are key cytokines involved in the pathophysiology of both immune-inflammatory and structural changes underlying type 2 asthma. IL-4 plays a pivotal role in Th2 cell polarization, immunoglobulin E (IgE) synthesis and eosinophil recruitment into the airways. IL-13 synergizes with IL-4 in inducing IgE production and also promotes nitric oxide (NO) synthesis, eosinophil chemotaxis, bronchial hyperresponsiveness and mucus secretion, as well as the proliferation of airway resident cells such as fibroblasts and smooth muscle cells. The biological effects of IL-4 and IL-13 are mediated by complex signaling mechanisms activated by receptor dimerization triggered by cytokine binding to the α-subunit of the IL-4 receptor (IL-4Rα). The fully human IgG4 monoclonal antibody dupilumab binds to IL-4Rα, thereby preventing its interactions with both IL-4 and IL-13. This mechanism of action makes it possible for dupilumab to effectively inhibit type 2 inflammation, thus significantly reducing the exacerbation of severe asthma, the consumption of oral corticosteroids (OCS) and the levels of fractional exhaled NO (FeNO). Dupilumab has been approved not only for the add-on therapy of severe asthma, but also for the biological treatment of atopic dermatitis and nasal polyposis. Full article
(This article belongs to the Special Issue Monoclonal Antibodies for Targeted Biological Treatment of Severe Asthma)
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