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Vaccines
Special Issues
Humoral and Cellular Response after Vaccination
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Humoral and Cellular Response after Vaccination

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: 30 November 2024 | Viewed by 747

Special Issue Editors

Dr. Adrian Onu

E-Mail Website
Guest Editor
1. “Cantacuzino” Institute, 050096 Bucharest, Romania
2. Faculty of Pharmacy, Titu Maiorescu University, 040317 Bucharest, Romania
Interests: vaccine technology; biotechnology; immune response; proteomics; protein biophysics
Dr. Iuliana Caras

E-Mail Website
Guest Editor
Cantacuzino, National Medical-Military Institute for Research and Development, 050096 Bucharest, Romania
Interests: immune response; innate immunity; dendritic cells; toll-like receptors

Special Issue Information

Dear Colleagues,

Efficient vaccination relies on inducing a robust adaptive immune response, both cellular and humoral, each playing a specific role in preventing or controlling infection. The challenge in developing an effective vaccine lies in finding the right balance between the different types of immune response required. To evaluate a vaccine, a range of methods have been developed. Immunization markers are constantly evolving, and sometimes newer markers from large data sets, identified through principal component analysis, replace traditional ones. In addition to the polarization of the immune response, the impact of immunization on innate immunity (trained immunity) calls for the use of additional instruments and concepts to assess vaccine effectiveness.

This special issue seeks to provide an overview of the current methodology for evaluating vaccines, from the design phase to clinical trials. The proposed articles aim to offer relevant insights into these concepts in the field of modern vaccination.

Dr. Adrian Onu
Dr. Iuliana Caras
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vaccine
  • infectious disease
  • humoral immunity
  • cellular immunity
  • innate immunity
  • trained immunity
  • pathogen
  • virus

Published Papers (1 paper)

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Research

14 pages, 892 KiB  
Article
Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG Sialylation
by Priti Gupta, Tibor Sághy, Miriam Bollmann, Tao Jin, Claes Ohlsson, Hans Carlsten, Carmen Corciulo and Cecilia Engdahl
Vaccines 2024, 12(5), 479; https://doi.org/10.3390/vaccines12050479 - 29 Apr 2024
Viewed by 252
Abstract
Age alters the host’s susceptibility to immune induction. Humoral immunity with circulating antibodies, particularly immunoglobulin G (IgG), plays an essential role in immune response. IgG glycosylation in the fragment crystallizable (Fc) region, including sialylation, is important in regulating the effector function by interacting [...] Read more.
Age alters the host’s susceptibility to immune induction. Humoral immunity with circulating antibodies, particularly immunoglobulin G (IgG), plays an essential role in immune response. IgG glycosylation in the fragment crystallizable (Fc) region, including sialylation, is important in regulating the effector function by interacting with Fc gamma receptors (FcγRs). Glycosylation is fundamentally changed with age and inflammatory responses. We aimed to explore the regulation of humoral immunity by comparing responses to antigen-induced immune challenges in young and adult mice using a local antigen-induced arthritis mouse model. This study examines the differences in immune response between healthy and immune-challenged states across these groups. Our initial assessment of the arthritis model indicated that adult mice presented more severe knee swelling than their younger counterparts. In contrast, we found that neither histological assessment, bone mineral density, nor the number of osteoclasts differs. Our data revealed an age-associated but not immune challenge increase in total IgG; the only subtype affected by immune challenge was IgG1 and partially IgG3. Interestingly, the sialylation of IgG2b and IgG3 is affected by age and immune challenges but not stimulated further by immune challenges in adult mice. This suggests a shift in IgG towards a pro-inflammatory and potentially pathogenic state with age and inflammation. Full article
(This article belongs to the Special Issue Humoral and Cellular Response after Vaccination)
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