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Vaccines
Special Issues
Immune Response after Vaccination in Patients with Inflammatory Diseases
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Immune Response after Vaccination in Patients with Inflammatory Diseases

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Innate and Adaptive Immunity in Vaccination".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1405

Special Issue Editors

Prof. Dr. Małgorzata Wisłowska

E-Mail Website
Guest Editor
Department of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland
Interests: the influence of immunomodulatory drugs; biological and synthetic targeted drugs; on immune response
Dr. Jakub Wroński

E-Mail
Guest Editor Assistant
Department of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland
Interests: the impact of immunomodulatory drugs; biological and synthetic targeted drugs; on the immunogenicity of vaccinations in patients with autoimmune inflammatory rheumatic diseases

Special Issue Information

Dear Colleagues,

Patients with autoimmune inflammatory diseases are among immune-incompetent patients. Altered functioning of the immune system and the use of immunomodulatory drugs make this group of patients more vulnerable to infections. The use of vaccines as a preventive measure against selected infectious diseases in patients with autoimmune inflammatory diseases is thus of paramount importance. Unfortunately, the same factors that make these patients more susceptible to infections also influence the post-vaccination response.

This Special Issue aims to feature papers that underscore aspects of the immune response after vaccination in patients with autoimmune inflammatory diseases, focusing on the immunogenicity of vaccines, the impact of immunomodulatory drugs on post-vaccination humoral and cellular responses, immunological mechanisms that influence the response in patients with autoimmune inflammatory diseases, and the translation of this knowledge into clinical practice. We welcome submissions of original research articles (both clinical and translational studies) as well as reviews.

We look forward to receiving your manuscripts.

Prof. Dr. Małgorzata Wisłowska
Guest Editor

Dr. Jakub Wroński
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunogenicity
  • cellular response
  • humoral response
  • vaccines
  • autoimmune diseases
  • inflammatory diseases
  • immunomodulatory treatment
  • disease-modifying antirheumatic drugs
  • biological drugs
  • targeted synthetic drugs

Published Papers (1 paper)

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Research

16 pages, 1958 KiB  
Article
A Study on Mortality Predictors in Hemodialysis Patients Infected with COVID-19: Impact of Vaccination Status
by Voin Brkovic, Gorana Nikolic, Marko Baralic, Milica Kravljaca, Marija Milinkovic, Jelena Pavlovic, Mirjana Lausevic and Milan Radovic
Vaccines 2024, 12(1), 2; https://doi.org/10.3390/vaccines12010002 - 19 Dec 2023
Cited by 1 | Viewed by 1203
Abstract
The global outbreak of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted significant public health concerns. This study focuses on 442 chronic hemodialysis patients diagnosed with COVID-19, emphasizing the impact of vaccination status on clinical outcomes. The study [...] Read more.
The global outbreak of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted significant public health concerns. This study focuses on 442 chronic hemodialysis patients diagnosed with COVID-19, emphasizing the impact of vaccination status on clinical outcomes. The study investigates the correlation between vaccination status and laboratory findings, aiming to identify predictive factors for mortality. Results indicate that vaccination status plays a crucial role in outcomes. Full vaccination, evidenced by two or three doses, is associated with better outcomes, including reduced incidence of bilateral pneumonia and lower risks of complications such as hemorrhage and thrombosis. Laboratory analyses reveal significant differences between vaccinated and unvaccinated patients in parameters like C-reactive protein, ferritin, and white blood cell counts. Univariate and multivariate Cox proportional hazards regression analyses identify several factors influencing mortality, including comorbidities, pneumonia development, and various inflammatory markers. In conclusion among hemodialysis patients affected by COVID-19 infection, vaccination with at least three doses emerges as a protective factor against fatal outcomes. Independent predictors of mortality are CRP levels upon admission, maximum CRP values during the illness and cardiovascular comorbidities. Noteworthy lymphocytopenia during infection exhibits a notable level of specificity and sensitivity in predicting mortality. Full article
(This article belongs to the Special Issue Immune Response after Vaccination in Patients with Inflammatory Diseases)
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