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Vaccines
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Anticancer Therapies: Drugs or Efficient Targets
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Anticancer Therapies: Drugs or Efficient Targets

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cancer Vaccines and Immunotherapy".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 1885

Special Issue Editors

Dr. Jian-Ye Zhang

E-Mail Website
Guest Editor
School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China
Interests: apoptosis; pharmacy cells; cancers; medicinal and pharmaceutical chemistry
Dr. Fernando Ferreira

E-Mail Website
Co-Guest Editor
Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal
Interests: veterinary oncology; veterinary virology; cellular and molecular biology; oncogenic mechanisms; molecular oncology; chromatin remodeling; cell-virus interactions; vaccines and cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last few decades, huge advances have been achieved in the treatment of different types of cancer. This Special Issue aims to explore and discuss the following two aspects: firstly, we need to understand the tumor-specific immune status of specific organs. The main factors promoting tumor growth are the intrinsic characteristics of tumor cells and the organs where the tumor locates. The organ where the tumor is located is a key factor affecting the balance of response or non-response to immunotherapy, which needs to be further explored. Secondly, it is necessary to explore how to use biomarkers to optimize personality therapy. At present, biomarkers related to immunotherapy face both opportunities and challenges, such as detection platform, reagent, cut-off value, single or compound prediction, etc., all of which need to be further explored.

This Special Issue will discuss the discovery of the development of therapeutics against cancers. Articles, reviews, case reports, and other types of submissions are welcome.

Dr. Jian-Ye Zhang
Dr. Fernando Ferreira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • immunotherapy
  • cancers
  • specific organs
  • tumor cells

Published Papers (1 paper)

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Research

11 pages, 253 KiB  
Article
The Correlation of Papanicolaou Smears and Clinical Features to Identify the Common Risk Factors for Cervical Cancer: A Retrospective and Descriptive Study from a Tertiary Care Hospital in Trinidad
by Srikanth Umakanthan, Maryann M. Bukelo, Saudah Ghany, La Donna Gay, Tia Gilkes, Jamila Freeman, Andre Francis, Kyle Francis, Gabriel Gajadhar and Junea Fraser
Vaccines 2023, 11(3), 697; https://doi.org/10.3390/vaccines11030697 - 18 Mar 2023
Cited by 1 | Viewed by 1577
Abstract
Background: Cervical cancer, the fourth most frequent cancer in women, is associated with the human papillomavirus (HPV). This study identifies risk factors and clinical findings for abnormal cervical cytology and histopathology in the Trinidad and Tobago populations. Some risk factors include early age [...] Read more.
Background: Cervical cancer, the fourth most frequent cancer in women, is associated with the human papillomavirus (HPV). This study identifies risk factors and clinical findings for abnormal cervical cytology and histopathology in the Trinidad and Tobago populations. Some risk factors include early age of first coitus, a high number of sexual partners, high parity, smoking, and using certain medications, such as oral contraception. This study aims to identify the significance of Papanicolaou (pap) smears and the common risk factors that contribute to the development of premalignant and malignant cervical lesions. Method: A three-year retrospective, descriptive study of cervical cancer was conducted at the Eric Williams Medical Sciences Complex. The subject population included 215 female patients aged 18 years and older with the following documented abnormal cervical cytology: (ASCUS), ASC-H, LSIL, HSIL, Atypical Glandular cells, HPV, Adenocarcinoma, and Invasive Squamous Cell Carcinoma. Histopathology records were analysed for thirty-three of these patients. Patients’ information was recorded on data collection sheets adapted from the North Central Regional Health Authority’s cytology laboratory standardised reporting format request form. Results and Findings: The data were analysed via Statistical Package for Social Sciences (SPSS) software edition 23 using frequency tables and descriptive analysis. The mean sample age of the population was 36.7 years, the first age of coitus was 18.1 years, the number of sexual partners was 3.8, and the number of live births was 2. LSIL was the most popular abnormal finding, 32.6%, followed by HSIL, 28.8%, and ASCUS, 27.4%. Most histopathological reports resulted in CIN I and II. Conclusions: The significant risk factors observed for cytology abnormalities and premalignant lesions were early age of coitus, a high number of sexual partners, and no use of contraception. Patients mostly presented as asymptomatic despite obtaining abnormal cytology results. Hence, regular pap smear screening should continue to be highly encouraged. Full article
(This article belongs to the Special Issue Anticancer Therapies: Drugs or Efficient Targets)
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