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Vaccines
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Porcine Vaccines: Enhancing Health, Productivity, and Welfare
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Porcine Vaccines: Enhancing Health, Productivity, and Welfare

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 3281

Special Issue Editor

Dr. Tongqing An

E-Mail Website
Guest Editor
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
Interests: PRRSV; PRV; molecular epidemiology; vaccine; diagnosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to invite you to submit your next publication to the journal Vaccines for a Special Issue entitled “Porcine Vaccines: Enhancing Health, Productivity, and Welfare”. Porcine reproductive and respiratory syndrome, porcine viral diarrhea, African swine fever, circovirus-related diseases, and others, seriously harm and restrict the healthy development of the pig industry. In recent years, many variants of porcine viruses have emerged and immunologically escaped from the current available vaccines, causing new challenges in the prevention of porcine diseases and required the updating of existing vaccines, antigens, or adjuvants. DIVA vaccines, multivalent vaccines, and antigen-precise-designed vaccines are the focus of current porcine vaccine research. In addition, oral, spray, and other needle-free vaccination delivery methods have seen strong demand for animal disease control in the future.

This Special Issue will focus on porcine vaccines, including vaccine design, development, effect evaluation, small-animal replacement models, DIVA, vaccination delivery methods, and so on. Original research articles, and comprehensive reviews are welcome. We look forward to receiving your contributions.

Prof. Dr. Tongqing An
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

24 pages, 3931 KiB  
Article
Deletion of MGF505-2R Gene Activates the cGAS-STING Pathway Leading to Attenuation and Protection against Virulent African Swine Fever Virus
by Sun-Young Sunwoo, Raquel García-Belmonte, Marek Walczak, Gonzalo Vigara-Astillero, Dae-Min Kim, Krzesimir Szymankiewicz, Maciej Kochanowski, Lihong Liu, Dongseob Tark, Katarzyna Podgórska, Yolanda Revilla and Daniel Pérez-Núñez
Vaccines 2024, 12(4), 407; https://doi.org/10.3390/vaccines12040407 - 11 Apr 2024
Viewed by 522
Abstract
African swine fever virus (ASFV) is the etiological agent causing African swine fever (ASF), affecting domestic pigs and wild boar, which is currently the biggest animal epidemic in the world and a major threat to the swine sector. At present, some safety concerns [...] Read more.
African swine fever virus (ASFV) is the etiological agent causing African swine fever (ASF), affecting domestic pigs and wild boar, which is currently the biggest animal epidemic in the world and a major threat to the swine sector. At present, some safety concerns about using LAVs against ASFV still exist despite a commercial vaccine licensed in Vietnam. Therefore, the efforts to identify virulence factors and their mechanisms, as well as to generate new vaccine prototypes, are of major interest. In this work, we have identified the MGF505-2R gene product as an inhibitor of the cGAS/STING pathway, specifically through its interaction with STING protein, controlling IFN-β production. In addition, immunization of a recombinant virus lacking this gene, Arm/07-ΔMGF505-2R, resulted in complete attenuation, demonstrating its involvement in ASFV virulence. Finally, immunization with Arm/07-ΔMGF505-2R induced the generation of antibodies and proved to be partially protective against virulent ASFV strains. These results identify MGF505-2R, as well as its mechanism of action, as a gene contributing to understanding the molecular mechanisms of ASFV virulence, which will be of great value in the design of future vaccine prototypes. Full article
(This article belongs to the Special Issue Porcine Vaccines: Enhancing Health, Productivity, and Welfare)
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24 pages, 8483 KiB  
Article
Application of Recombinant Lactic Acid Bacteria (LAB) Live Vector Oral Vaccine in the Prevention of F4+ Enterotoxigenic Escherichia coli
by Jiangxu Yu, Jiyang Fu, Hongshuo Liu, Chao Kang, Zesong Wang, Yancheng Jin, Shuxuan Wu, Tianzhi Li, Ruicheng Yang, Meilin Jin, Huanchun Chen and Xiangru Wang
Vaccines 2024, 12(3), 304; https://doi.org/10.3390/vaccines12030304 - 14 Mar 2024
Viewed by 817
Abstract
Enterotoxigenic Escherichia coli (ETEC) causes severe diarrhea in piglets. The current primary approach for ETEC prevention and control relies on antibiotics, as few effective vaccines are available. Consequently, an urgent clinical demand exists for developing an effective vaccine to combat this disease. Here, [...] Read more.
Enterotoxigenic Escherichia coli (ETEC) causes severe diarrhea in piglets. The current primary approach for ETEC prevention and control relies on antibiotics, as few effective vaccines are available. Consequently, an urgent clinical demand exists for developing an effective vaccine to combat this disease. Here, we utilized food-grade Lactococcus lactis NZ3900 and expression plasmid pNZ8149 as live vectors, together with the secreted expression peptide Usp45 and the cell wall non-covalent linking motif LysM, to effectively present the mutant LTA subunit, the LTB subunit of heat-labile enterotoxin, and the FaeG of F4 pilus on the surface of recombinant lactic acid bacteria (LAB). Combining three recombinant LAB as a live vector oral vaccine, we assessed its efficacy in preventing F4+ ETEC infection. The results demonstrate that oral immunization conferred effective protection against F4+ ETEC infection in mice and piglets lacking maternal antibodies during weaning. Sow immunization during late pregnancy generated significantly elevated antibodies in colostrum, which protected piglets against F4+ ETEC infection during lactation. Moreover, booster immunization on piglets during lactation significantly enhanced their resistance to F4+ ETEC infection during the weaning stage. This study highlights the efficacy of an oral LAB vaccine in preventing F4+ ETEC infection in piglets by combining the sow immunization and booster immunization of piglets, providing a promising vaccination strategy for future prevention and control of ETEC-induced diarrhea in piglets. Full article
(This article belongs to the Special Issue Porcine Vaccines: Enhancing Health, Productivity, and Welfare)
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17 pages, 5610 KiB  
Article
New Formulation of a Subunit Vaccine Candidate against Lawsonia intracellularis Increases Humoral and Cellular Immune Responses
by Santiago Salazar, María Francisca Starck, Milton F. Villegas, Jannel Acosta, Oliberto Sánchez, Eduardo Ramos, Estefanía Nova-Lamperti, Jorge R. Toledo, Paula Gädicke, Álvaro Ruiz, Alaín González and Raquel Montesino
Vaccines 2023, 11(12), 1817; https://doi.org/10.3390/vaccines11121817 - 04 Dec 2023
Viewed by 1270
Abstract
Previously, we designed a subunit vaccine candidate based on three L. intracellularis antigens with promising results in pigs. In this study, antigens were produced individually to achieve an even antigen ratio in the formulation. The emulsion characterization included the drop size and the [...] Read more.
Previously, we designed a subunit vaccine candidate based on three L. intracellularis antigens with promising results in pigs. In this study, antigens were produced individually to achieve an even antigen ratio in the formulation. The emulsion characterization included the drop size and the mechanical and thermal stability. Immune response was evaluated by indirect and sandwich ELISAs, qPCR, and flow cytometry. The vaccine candidate’s safety was assessed by histopathology and monitoring the clinical behavior of animals. The average production yielded for the chimeric antigen as inclusion bodies was around 75 mg/L. The formulation showed mechanical and thermal stability, with a ratio Hu/Ho > 0.85 and a drop size under 0.15 nm. Antigens formulated at a ratio of 1:1:1 induced a significant immune response in inoculated pigs that persisted until the end of the experiment (week 14). The dose of 200 μg significantly activated cellular response measured by transcriptional and translational levels of cytokines. The cell proliferation assay revealed an increment of lymphocytes T CD4+ at the same dose. Animals gained weight constantly and showed proper clinical behavior during immunization assays. This research demonstrated the immunological robustness of the new subunit vaccine candidate against Porcine Proliferative Enteropathy evenly formulated with three chimeric antigens of L. intracellularis. Full article
(This article belongs to the Special Issue Porcine Vaccines: Enhancing Health, Productivity, and Welfare)
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