Vaccine Strategies for HPV-Related Cancers

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: 31 July 2024 | Viewed by 2950

Special Issue Editor


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Guest Editor
1. Departments of Family Medicine and Obstetrics & Gynecology, University of Michigan, Ann Arbor, MI, USA
2. Department of Biomedical Engineering, U-M College of Engineering, University of Michigan, Ann Arbor, MI, USA
3. Department of Women's and Gender Studies, U-M College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, USA
Interests: HPV associated diseases; screening and prevention of cervical cancer
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Special Issue Information

Dear Colleagues,

Human papillomavirus (HPV) vaccines were purposefully designed to cover HPV 16 and 18, which are associated with about 70% of cervical cancers and about 90% of HPV-associated head & neck and anal cancers. Enough time has elapsed to see early indicators of the reduction in cancers associated with HPV. Other types of HPV will be clinically unmasked as the natural infection types are blocked. Following the change in distribution of HPV types causing the associated cancers will be important to note so that the modeling studies for future prognostic health planning can be modified. HPV vaccine administration appears to be sufficient at one dose for children 9 years of age. Increasing population coverage with a single dose offers more efficiency and equity in vaccine distribution. Understanding person-level and population-level barriers and facilitators to the original vaccine uptake are needed. Separately, the development of pan-HPV vaccines as the next generation vaccine is imperative. Continuing to leave oncogenic HPV types out of the vaccine perpetuates HPV-associated cancer inequities.

Dr. Diane M. Harper
Guest Editor

Manuscript Submission Information

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Keywords

  • HPV vaccine uptake
  • single dose immunization
  • clinical unmasking
  • HPV-associated cancers

Published Papers (2 papers)

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Research

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16 pages, 788 KiB  
Article
Understanding Barriers to Human Papillomavirus Vaccination among Parents of 9–10-Year-Old Adolescents: A Qualitative Analysis
by Denny Fe G. Agana-Norman, Monica Martinez Martinez, Manjushree Shanmugasundaram and Abbey B. Berenson
Vaccines 2024, 12(3), 245; https://doi.org/10.3390/vaccines12030245 - 27 Feb 2024
Viewed by 1506
Abstract
HPV vaccination rates remain low among US adolescents, with only 54% completing the series in 2019. The vaccine is recommended at age 11–12 but can be given as early as age 9. Although it has been found that offering the vaccine earlier improves [...] Read more.
HPV vaccination rates remain low among US adolescents, with only 54% completing the series in 2019. The vaccine is recommended at age 11–12 but can be given as early as age 9. Although it has been found that offering the vaccine earlier improves completion rates by age 13, parents remain reluctant to allow their younger children to initiate this vaccine. The purpose of this study was to better understand parental beliefs regarding receipt of the HPV vaccine among their children at ages 9–10. A 40 min phone interview was completed with 21 participants who were asked about their vaccine viewpoints. Even after receiving one-on-one education from a patient navigator, many caretakers expressed inadequate knowledge of the HPV vaccine and limited exposure to both positive and negative influences. The biggest concern was vaccine side effects, often resulting from a lack of medical understanding. Most parents were reluctant to vaccinate their children at a school-based clinic or pharmacy and believed that the government should not mandate HPV vaccination for public school attendance. Our study provides insight into parental beliefs and attitudes about HPV vaccination at age 9–10 years and barriers that need to be addressed. Full article
(This article belongs to the Special Issue Vaccine Strategies for HPV-Related Cancers)

Review

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15 pages, 317 KiB  
Review
Human Papillomavirus Vaccination in Pediatric, Adolescent, and Young Adult Cancer Survivors—Opportunity to Address Gaps in Cancer Prevention and Survivorship
by Melissa A. Kluczynski, Elisa M. Rodriguez, Cailey S. McGillicuddy and Nicolas F. Schlecht
Vaccines 2024, 12(2), 114; https://doi.org/10.3390/vaccines12020114 - 24 Jan 2024
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Abstract
The risks of secondary cancers associated with human papillomavirus (HPV) infection are as much as three times higher for survivors of pediatric, adolescent, and young adult cancer (PYAC) compared to the general population. Despite this, HPV vaccination rates among PYAC survivors remain low. [...] Read more.
The risks of secondary cancers associated with human papillomavirus (HPV) infection are as much as three times higher for survivors of pediatric, adolescent, and young adult cancer (PYAC) compared to the general population. Despite this, HPV vaccination rates among PYAC survivors remain low. Whereas pediatric oncology providers endorse HPV vaccination of PYAC survivors, many lack the resources or opportunities to intervene. The responsibility of HPV vaccination, therefore, falls to primary care providers and practices. This article provides an overview of the challenges with HPV vaccination that are distinct to PYAC survivors and discusses potential strategies to increase HPV vaccine coverage in this population. Full article
(This article belongs to the Special Issue Vaccine Strategies for HPV-Related Cancers)

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: HPV Vaccination in Pediatric and Young Adult Cancer Survivors – Opportunity to Address Gaps in Cancer Prevention and Survivorship
Author: Schlecht
Highlights: • Despite increased risk for HPV-related secondary cancers among pediatric-and-young-adult cancer (PYAC) survivors, HPV vaccination rates remain low in this population. • Whereas pediatric oncology providers endorse HPV vaccination of PYAC survivors, the responsibility typically remains with primary care providers. • Cancer transition of care models that integrate evidence-based strategies offer an opportunity for increasing HPV vaccination rates among PYAC survivors.

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