Understanding Immune Responses to COVID-19 Vaccines

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "COVID-19 Vaccines and Vaccination".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1224

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Department of RDAT, the Regina Elena National Cancer Institute IRCCS, Via Elio Chianesi 53, 00144 Rome, Italy
Interests: viral (HPV) carcinogenesis; oxidative stress; ultraviolet radiation; skin carcinogenesis; cancer progression; cancer microenvironment; proteins' oxidation and carcinogenesis
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Special Issue Information

Dear Colleagues,

The availability of safe and effective vaccines for the SARS-CoV-2 virus proved crucial in containing and mitigating the COVID-19 pandemic globally. Despite the significant work conducted by the scientific and social communities and the great results achieved in containing the disease, there is a long way to go. Several critical biological and clinical issues must be addressed, including the emergence of variants and the short duration of protective immunity. These issues are not the only critical areas of inquiry, and questions relating to patients with disabilities, patients in critical age groups, and other frail individuals are yet to be adequately addressed.

To discuss and share the latest research results and develop new ideas, we are launching a Special Issue, entitled ‘Understanding Immune Responses to COVID-19 Vaccines’ which is actually the 2nd edition of ‘Immune Responses to COVID-19 Vaccines’.

Dr. Federico De Marco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • variants and the short duration of protective immunity
  • immune responses
  • COVID-19 vaccines

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Published Papers (1 paper)

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Research

13 pages, 1287 KiB  
Article
Comparative Analysis of SARS-CoV-2 Antibody Responses across Global and Lesser-Studied Vaccines
by José Victor Zambrana, Carlos Saenz, Hannah E. Maier, Mayling Brenes, Andrea Nuñez, Anita Matamoros, Mabel Hernández, Keyla Dumas, Cristhian Toledo, Leonardo Peralta, Aubree Gordon and Angel Balmaseda
Vaccines 2024, 12(3), 326; https://doi.org/10.3390/vaccines12030326 - 19 Mar 2024
Viewed by 937
Abstract
Few data are available on antibody response for some SARS-CoV-2 vaccines, and there is a lack of ability to compare vaccine responses in the same population. This cross-sectional study conducted in Nicaragua examines the SARS-CoV-2 antibody responses in individuals, previously exposed to high [...] Read more.
Few data are available on antibody response for some SARS-CoV-2 vaccines, and there is a lack of ability to compare vaccine responses in the same population. This cross-sectional study conducted in Nicaragua examines the SARS-CoV-2 antibody responses in individuals, previously exposed to high infection rates who have received various vaccines. The vaccines under comparison include well-known ones like Pfizer (BNT162b2) and AstraZeneca (ChAdOx1-S), alongside less-studied vaccines including Soberana (Soberana 02), Abdala (CIGB-66), and Sputnik V/Sputnik Light. Overall, 3195 individuals participated, with 2862 vaccinated and 333 unvaccinated. We found that 95% of the unvaccinated were seropositive, with much lower titers than the vaccinated. Among the vaccinated, we found that Soberana recipients mounted the highest anti-spike response (mean difference (MD) = 36,498.8 [20,312.2, 52,685.5]), followed by Abdala (MD = 25,889.9 [10,884.1, 40,895.7]), BNT162b2 (MD = 12,967.2 [7543.7, 18,390.8]) and Sputnik with AstraZeneca as the reference group, adjusting for age, sex, vaccine status, days after last dose, and self-reported COVID-19. In addition, we found that subjects with complete vaccination series had higher antibody magnitude than those with incomplete series. Overall, we found no evidence of waning in the antibody magnitude across vaccines. Our study supports the conclusion that populations with high infection rates still benefit substantially from vaccination. Full article
(This article belongs to the Special Issue Understanding Immune Responses to COVID-19 Vaccines)
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