Cellular and Molecular Mechanisms that Control and Regulate Immune Responses after Liver Transplantations

Dear Colleagues,

The era of success in solid organ transplantation started with the clarification of the immunologic mechanisms that govern graft rejection and induction of immune tolerance. The advent of immunosuppressive therapy resulted in sustained prolonged graft and patient survival.

Cellular and humoral rejection in liver transplantation is a factor that threatens long-term graft survival. Furthermore, idiopathic graft fibrosis in a patient with, a seemingly uneventful postoperative course, is a major problem that is occasionally encountered. Subclinical cellular and humoral rejection may be the underlying mechanism of idiopathic graft fibrosis. However, the evidence regarding this theory is inconclusive.

Although there are many research teams around the world working on the mechanisms of immune responses in liver transplantation, the majority of transplantation research mainly focuses on the technical aspects of the procedure.  

It is our opinion that all the research in the field of transplant immunology should be concentrated on a single or a series of concise contemporary issues. Together with this objective in mind, we invite colleagues around the world to submit their basic science and original research studies, and review articles to this Special Issue entitled “Cellular and Molecular Mechanisms that Control and Regulate Immune Responses after Liver Transplantations” to be published in Vaccines, which has a high impact and is a highly respected journal in the field. We welcome molecular and basic science research as well as clinical observations and experiences in the field.

We hope that researchers in the field will have the highest interest in our special. We are looking forwards to all of the studies being submitted to our Special Issue.

Prof. Dr. Sami Akbulut
Prof. Dr. Tevfik Tolga Şahin
Guest Editors

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• liver transplantation
• deceased donor liver transplantation
• living donor liver transplantation
• graft versus host disease
• immune tolerance
• T-cell-mediated rejection (TCMR)
• antibody-mediated rejection (AMR)
• immunosuppressive medications
• cellular and molecular mechanisms of action of immunosuppressants