Pharmacokinetics and Clinical Pharmacology of Biological Drugs
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Clinical Pharmaceutics".
Deadline for manuscript submissions: closed (30 October 2023) | Viewed by 201
Special Issue Editors
Interests: pharmacokinetics and clinical pharmacology
Special Issue Information
Dear Colleagues,
Biological drugs, also commonly known as biologics, are complex products derived from living organisms or cells. They are made using biotechnology methods and contain active substances that are typically large, complex molecules such as proteins, peptides, or nucleic acids. The use of biological drugs has grown in the past two decades to treat a wide range of diseases, including cancer, autoimmune disorders, and infectious diseases. Pharmacokinetic (PK) and pharmacodynamic (PD) properties play an important role in the consideration of these biologics for designing the dosage regimen, bio-similarity, and/or interchangeability of biological drugs. The pharmacokinetic properties of biologics, including monoclonal antibodies (mAbs) and other therapeutic proteins, can be quite different from small molecule drugs in different aspects, which makes the PK/PD model development more challenging and requires extra efforts to understand their ADME.
This Special Issue aims to invite researchers to share their research work demonstrating the pharmacokinetics and metabolism of biologics. This Special Issue will also cover broad interests in wielding diverse drug delivery systems to achieve the PK/PD optimization of biological drugs. This Special Issue also welcomes review articles concerning the clinical pharmacology of biologicals from experts.
We look forward to receiving your contributions.
Dr. Kanumuri Siva Rama Raju
Dr. Guru R. Valicherla
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacokinetics and metabolism
- biologicals
- pharmacokinetics and pharmacodynamic studies
- bioavailability
- drug delivery of biologics
