Microfluidic Vascularized Tissue Model-Based Drug Transport and Pharmacokinetics

Dear Colleagues,

We are pleased to invite you to publish your research in this new Special Issue of the Pharmaceutics journal, titled "Microfluidic Vascularized Tissue Model-Based Drug Transport and Pharmacokinetics".

The significance of the research area lies in the transformative potential it offers to the entire drug development process. Microfluidic vascularized tissue models address several critical challenges, for example, enhanced physiological relevance, improved drug screening and toxicity testing, personalized medicine approaches, reduction in animal testing, etc.

The articles included in this Special Issue will present a comprehensive exploration of this exciting research area, highlighting the transformative impact of microfluidic vascularized tissue models on drug development and providing insights into their potential clinical applications.

This Special Issue, titled “Advanced Microfluidic Vascularized Tissue as a Platform for Drug Development”, in the Pharmaceutics journal aims to explore and showcase the cutting-edge research and advancements in the field of microfluidic vascularized tissue models and their application in drug development and related areas.

In this Special Issue, original research articles and reviews are welcome. The scope of this Special Issue could include, but is not limited to, the following topics:

1. Microfluidic vascularized tissue models: overview and development of various microfluidic systems that replicate vascularized tissue structures, including blood vessels, capillaries, and organ-on-a-chip models;
2. Drug screening and toxicity testing: studies demonstrating the use of microfluidic vascularized tissue models for drug screening, efficacy evaluation, and toxicity testing. This could encompass the testing of pharmaceutical compounds, novel drug candidates, and personalized medicine approaches;
3. Bioprinting and tissue engineering: advances in bioprinting technologies and tissue engineering techniques used to create complex vascularized tissue models in microfluidic platforms;
4. Organ-specific microfluidic models: focused research on specific organs or tissues, highlighting the relevance of vascularized models in drug development for diseases affecting these organs;
5. Drug transport and pharmacokinetics: investigations into drug transport, distribution, and pharmacokinetic studies using microfluidic vascularized tissue models;
6. Incorporation of immune and inflammatory responses: studies integrating immune cells and inflammatory responses in microfluidic vascularized tissue models to assess drug efficacy and immunomodulatory effects;
7. Microfluidic–biomaterial interactions: exploration of biomaterial interactions within microfluidic vascularized tissue models and their implications for drug development;
8. Regulatory and ethical considerations: discussions on the regulatory and ethical aspects of using advanced microfluidic vascularized tissue models in drug development and their potential translation to clinical applications;
9. Industrial applications and commercialization: studies showcasing the practical applications of microfluidic vascularized tissue models in the pharmaceutical industry and their potential for commercialization.

Overall, this Special Issue aims to bring together high-quality research articles, reviews, and perspectives from experts in the field to advance the understanding and utilization of microfluidic vascularized tissue models as a powerful tool in drug development and translational research. It will serve as a valuable resource for researchers, academics, and industry professionals interested in the forefront of pharmaceutical research and innovation.

We look forward to receiving your contributions.

Dr. Cucullo Luca
Dr. Snehal Raut
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• microfluidic
• organ-on-a-chip
• disease modeling
• drug screening