Brain Tumors Treatment: Current and Future Challenges from Drug Formulations to Delivery Methods
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".
Deadline for manuscript submissions: 16 August 2024 | Viewed by 311
Special Issue Editors
Interests: natural products; drug delivery systems; nanocarriers; topical administration; oral administration; brain delivery
Special Issues, Collections and Topics in MDPI journals
Interests: brain tumor; medulloblastoma; glioma; pediatric tumor; epigenetics; metabolism
Special Issue Information
Dear Colleagues,
Drug delivery to the brain remains a substantial challenge in the fight against brain tumors. Most primary brain tumors, in particular high-grade gliomas, continue to be untreatable and therefore, have a dismal prognosis. The presence of the blood–brain barrier, a specialized structure at the microvasculature level that regulates the transport of molecules across the blood vessels into the brain parenchyma, is among the key factors that have made the development of targeted therapies against brain tumors such a difficult task.
In addition, the blood-brain barrier is characterized by a high level of heterogeneity both intratumor and intertumor. In other words, designing a successful drug delivery method requires a deep understanding of the pathophysiology around the blood–brain barrier in different tumor types. Currently, only around 5% of the available tumor therapies have a molecular weight lower than 500 Da and high lipophilicity, which are necessary requirements to reach the brain via systemic administration.
We are pleased to invite you to contribute to this Special Issue, titled ‘Brain Tumor Treatment: Current and Future Challenges From Drug Formulations to Delivery Methods’.
The main purpose of this Special Issue is to gather original experimental insights or thought-provoking review articles that aim to shed light on the molecular regulation governing blood–brain barrier pathophysiology and its interplay with current treatments for brain tumors and to emphasize the need for new drug delivery techniques and formulations to improve the survival of patients, possibly proposing new avenues for therapeutic approaches for brain tumors.
Prof. Dr. Anna Rita Bilia
Dr. Sara Badodi
Dr. Loredana Guglielmi
Guest Editors
Manuscript Submission Information
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Keywords
- blood–brain barrier pathophysiology in different tumors
- pediatric brain tumors
- adult brain tumors
- considerations for adult vs. pediatric drug delivery development
- nanocarriers and nanoparticles
- focused ultrasound
- convection enhanced delivery
- intranasal delivery
- intra-arterial delivery
- combination strategies
