Drug Monitoring of Antibiotics in the Era of Precision Dosing
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Clinical Pharmaceutics".
Deadline for manuscript submissions: 10 June 2024 | Viewed by 109
Special Issue Editors
2. Clinical Pharmacology Unit, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy
Interests: drug monitoring; antibiotics; precision dosing; pharmacokinetics; pharmacodynamics; PK/PD relationship; clinical pharmacology; clinical pharmacokinetics; population pharmacokinetics
2. Clinical Pharmacology Unit, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy
Interests: drug monitoring; antibiotics; precision dosing; pharmacokinetics; pharmacodynamics; PK/PD relationship; clinical pharmacology; population pharmacokinetics; model-informed precision dosing
Special Issue Information
Dear Colleagues,
Drug monitoring of antibiotics is a fundamental tool for the attainment of the PK/PD targets associated with favourable clinical outcomes and a reduction in the toxicity of established and novel drugs. Nowadays, precision dosing of antibiotics is spreading in clinical practice, thanks to the diffusion of gold-standard techniques of drug quantitation like LC-MS/MS. The specific quantification of antibiotics enables the reliable set up of population pharmacokinetic models to guide clinician dosing adjustments in specific patient populations. Expert clinical pharmacologists’ measurement and interpretation of drug concentrations is essential to support the antimicrobial stewardship, along with the informed opinion of fellow infectivologists and microbiologists, to unlock the full clinical benefit of a therapeutic intervention.
In this Special Issue of Pharmaceutics, we aim to publish novel clinical evidence and/or reviews supporting dosing optimization of antibiotic treatments by therapeutic drug monitoring and PK/PD pharmacokinetics principles for precision dosing recommendations.
Dr. Francesca Mattioli
Dr. Giammarco Baiardi
Guest Editors
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Keywords
- drug monitoring
- antibiotics
- precision dosing
- TDM-guided dosing
- PK/PD relationship
- HPLC
- LC-MS/MS
- antimicrobial stewardship
- clinical pharmacology
- population pharmacokinetics
- model-informed precision dosing
