Cancer Treatment Toxicities: Molecular Insights and Novel Therapeutic Approaches

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1673

Special Issue Editors


E-Mail Website
Guest Editor
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza 60430-270, Brazil
Interests: inflammation; cancer; cancer chemotherapy toxicities

E-Mail Website
Guest Editor
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza 60430-270, Brazil
Interests: inflammation; cancer; cancer chemotherapy toxicities

Special Issue Information

Dear Colleagues,

Cancer is a group of challenging diseases with high incidence and mortality. It is one of the leading causes of death in the world. According to the Global Cancer Observatory, 30.2 million new cases of cancer and 16.3 million deaths are expected by 2040. There are also an estimated 50 million current survivors of this pathology, many of whom have sequelae from the toxic effects of oncological treatments. Remarkably, the still-unsatisfactory knowledge of the pathogenesis of most of these side effects is reflected in the small number of protective therapeutic options. Consequently, adverse severe effects often lead to treatment discontinuation, compromising its overall effectiveness, and increasing the costs for the health system, becoming a critical public health problem.                    

Identifying molecular targets to develop novel therapeutic approaches opens perspectives for the effective clinical management of the side effects of cancer treatment, reducing morbidity and increasing patients’ quality of life.                   

The journal Pharmaceuticals welcomes high-quality reviews and original articles that focus on experimental, clinical, or translational research on the pathogenesis of cancer treatment toxicities and the discovery of novel therapeutic compounds to manage these side effects. The collection of manuscripts will be published as a Special Issue.

Dr. Roberto César Pereira Lima-Júnior
Dr. Deysi Viviana Tenazoa Wong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer treatment toxicities
  • side effects
  • pathogenesis
  • inflammation
  • pain
  • animal models
  • drug target discovery
  • preclinical and clinical drug research
  • natural compounds

Published Papers (1 paper)

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Review

20 pages, 2183 KiB  
Review
Targeting Hypoxia-Inducible Factor-1 (HIF-1) in Cancer: Emerging Therapeutic Strategies and Pathway Regulation
by Reem A. Qannita, Ayah I. Alalami, Amani A. Harb, Shereen M. Aleidi, Jalal Taneera, Eman Abu-Gharbieh, Waseem El-Huneidi, Mohamed A. Saleh, Karem H. Alzoubi, Mohammad H. Semreen, Mohammad Hudaib and Yasser Bustanji
Pharmaceuticals 2024, 17(2), 195; https://doi.org/10.3390/ph17020195 - 01 Feb 2024
Viewed by 1362
Abstract
Hypoxia-inducible factor-1 (HIF-1) is a key regulator for balancing oxygen in the cells. It is a transcription factor that regulates the expression of target genes involved in oxygen homeostasis in response to hypoxia. Recently, research has demonstrated the multiple roles of HIF-1 in [...] Read more.
Hypoxia-inducible factor-1 (HIF-1) is a key regulator for balancing oxygen in the cells. It is a transcription factor that regulates the expression of target genes involved in oxygen homeostasis in response to hypoxia. Recently, research has demonstrated the multiple roles of HIF-1 in the pathophysiology of various diseases, including cancer. It is a crucial mediator of the hypoxic response and regulator of oxygen metabolism, thus contributing to tumor development and progression. Studies showed that the expression of the HIF-1α subunit is significantly upregulated in cancer cells and promotes tumor survival by multiple mechanisms. In addition, HIF-1 has potential contributing roles in cancer progression, including cell division, survival, proliferation, angiogenesis, and metastasis. Moreover, HIF-1 has a role in regulating cellular metabolic pathways, particularly the anaerobic metabolism of glucose. Given its significant and potential roles in cancer development and progression, it has been an intriguing therapeutic target for cancer research. Several compounds targeting HIF-1-associated processes are now being used to treat different types of cancer. This review outlines emerging therapeutic strategies that target HIF-1 as well as the relevance and regulation of the HIF-1 pathways in cancer. Moreover, it addresses the employment of nanotechnology in developing these promising strategies. Full article
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