Advances in Peptide Chemistry and Medicinal Application
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 87
Special Issue Editor
Interests: medicinal chemistry; drug design; peptide chemistry; peptidomimetics; small molecules; structure–activity relationships studies; cysteine protease inhibitors; neurotensin analogues
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the last decades, advances in peptide chemistry led to significant findings. The development of peptides and peptidomimetics has paved the way toward the molecular modulation mechanisms of receptors, protein–protein interactions, modulation of the catalytic activity of enzymes, therapeutic antibodies, hydrogels, etc.
Optimization of synthetic protocols has played a key role in the development of peptide derivatives. Advances in solid-phase peptide synthesis, large variety of coupling reagents, novel procedures for the use of eco-friendly agents and solvents, as well as the incorporation of unnatural amino acids and modifications along the peptide backbone, have led to an impressive number of derivatives covering multiple therapeutic areas.
Peptide-based ligands bind to a large panel of targets, resulting in strong affinity, significant biological diversity and wide margins of optimization.
However, several issues, such as protease-mediated degradation, toxicity, selectivity and oral absorption, negatively influence the development of peptide derivatives. Whilst important findings have been achieved, several challenges await the scientific community, and further efforts aimed to improve the drug-like properties of peptide-based compounds should be made.
This Special Issue aims to collect research and review articles regarding the development of peptide-based compounds. Synthesis optimization, structure–activity relationship (SAR) studies and biological investigations of both diagnostic and theranostic peptides and peptidomimetics are welcome. The development of novel amino acids, building blocks and hydrogels, as well as NMR studies, in silico prediction and fluorescent probes will also be taken into consideration.
Dr. Santo Previti
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- peptide-based compounds
- peptidomimetics
- drug discovery
- drug-like properties
- target modulation
- structure–activity relationship studies
- unnatural amino acids
- backbone modifications
- antibodies
- hydrogels
