Special Issue "Natural Products for the Treatment of Rheumatic Diseases"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 25 February 2024 | Viewed by 2165

Special Issue Editors

Grupo de Investigación en Reumatología y Salud (GIR-S), Departamento de Biología, Facultad de Ciencias, Universidade da Coruña, 15071 A Coruña, Spain
Interests: chondrocytes; osteoarthritis; diabetes; aging; inflammation; hydrogen sulphide; brown algae
Unidad de Epigenética, Grupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, 15006 A Coruña, Spain.
Interests: epigenetics; osteoarthritis; nutraceuticals

Special Issue Information

Dear Colleagues,

Rheumatic diseases are a heterogeneous group of disorders mainly affecting joints and other surrounding tissues, but in some cases even organs. Some of these pathologies are among the most common diseases worldwide; however, many of them are chronic conditions with no cure.

Since there are more than 200 different diseases affecting the musculoskeletal system, their treatments are also varied in nature. Nevertheless, the main goals are management and relief of pain, reducing inflammation in affected tissues, reduction and prevention of joint damage, and preservation of joint mobility. With these aims, the used medications include analgesics, Non-Steroidal Anti-Inflammatory Agents (NSAIDs), steroids, Disease-Modifying Anti-Rheumatic Drugs (DMARDs), and biologic response modifiers. Unfortunately, prolonged administration of NSAIDs, steroids, and DMARDs is commonly associated with deleterious side effects.

Therefore, in the pursuit of new and safer approaches for rheumatic disease management, natural products have gained a great interest within food and non-food sectors due their healthy properties such as antioxidant, anti-inflammatory, anti-apoptotic and other qualities related to joint health. Thus, a growing number of studies suggest the benefits of supplementation with nutritional and herbal components, such as phenolics, flavonoids, and carotenoids, as well as different diets such as the vegan or traditional Mediterranean diets.

Herein, this Special Issue invites all researchers and clinicians to publish works concerning the use of natural bioactive compounds as a complementary and alternative treatment of musculoskeletal disorders. 

Dr. Carlos Vaamonde-García
Dr. María Carmen De Andrés
Guest Editors

Manuscript Submission Information

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  • mediterranean diet
  • flavonoids
  • phenolic compounds
  • carotenoids
  • oils
  • fatty acids
  • herbal byproducts
  • arthritis
  • osteoarthritis
  • systemic lupus erythematosus, gout

Published Papers (1 paper)

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20 pages, 3455 KiB  
Effects of Oleacein, a New Epinutraceutical Bioproduct from Extra Virgin Olive Oil, in LPS-Activated Murine Immune Cells
Pharmaceuticals 2022, 15(11), 1338; https://doi.org/10.3390/ph15111338 - 28 Oct 2022
Cited by 3 | Viewed by 1612
The present study was designed to evaluate the immunomodulatory effects of the secoiridoid from extra virgin olive oil, oleacein (OLA), deepening into the possible signaling pathways involved in LPS-activated murine peritoneal macrophages. Moreover, we have explored OLA-induced epigenetic changes in histone markers and [...] Read more.
The present study was designed to evaluate the immunomodulatory effects of the secoiridoid from extra virgin olive oil, oleacein (OLA), deepening into the possible signaling pathways involved in LPS-activated murine peritoneal macrophages. Moreover, we have explored OLA-induced epigenetic changes in histone markers and related cytokine production in murine LPS-stimulated murine splenocytes. Murine cells were treated with OLA in the presence or absence of LPS (5 μg/mL) for 18 or 24 h. OLA modulated the oxidative stress and the inflammatory response produced by LPS stimulation in murine peritoneal macrophages, by the inhibition of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β, IFN-γ, IL-17 and IL-18) and ROS production and the expression of pro-inflammatory enzymes such as iNOS, COX-2 and m-PGES1. These protective effects could be due to the activation of the Nrf-2/HO-1 axis and the inhibition of JAK/STAT, ERK and P38 MAPKs and inflammasome canonical and non-canonical signaling pathways. Moreover, OLA modulated epigenetic modifications throughout histone methylation deacetylation (H3K18ac) and (H3K9me3 and H3K27me) in LPS-activated spleen cells. In conclusion, our data present OLA as an interesting anti-inflammatory and antioxidant natural compound that is able to regulate histone epigenetic markers. Nevertheless, additional in vivo studies are required to further investigate the beneficial effects of this EVOO secoiridoid, which might be a promising epinutraceutical bioproduct for the management of immune-related inflammatory diseases. Full article
(This article belongs to the Special Issue Natural Products for the Treatment of Rheumatic Diseases)
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