Antiradical, Chemopreventive and Antimicrobial Effects of Bioactive Natural Substances

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 3095

Special Issue Editor


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Guest Editor
Department of Pharmacognosy with the Medicinal Plant Garden, Faculty of Pharmacy, Medical University of Lublin, Collegium Universum, 1 Chodźki Street, 20-093 Lublin, Poland
Interests: phytochemistry; phytotherapy; phytochemical analysis; biological and pharmacological effects of plant constituents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Numerous phytochemical and biological studies conducted with herbal substances or foods of plant origin confirm the strong correlation between the consumption of natural products rich in antioxidant components and chemoprevention as a process of reducing the risk of carcinogenesis or delaying the recurrence of cancer. Specialised plant metabolites (mainly phenolics), showing low or minimal toxicity, play a key role in this health-promoting strategy. As effective radical scavengers, they can directly inactivate exo- and endogenous reactive forms that are harmful to the human genome and initiate tissue degeneration, especially in relation to the hepatocellular, cardiovascular, and nervous systems. In addition, natural antioxidants may also operate by activating immune defence mechanisms, showing beneficial anti-inflammatory effects at various cellular and biochemical levels or enhancing the potency of chemotherapeutics routinely used to treat cancer. A large number of herbal ingredients have also been successful in combating pathogenic microbial species, including antibiotic-resistant bacteria, or altering the profile of the gut microbiota, thereby enhancing regulatory molecular mechanisms helpful in effectively fighting various devastating diseases.

In this Special Issue, preference will be given to review and experimental papers addressing the above topics. Particularly valuable will be papers combining detailed phytochemical analysis of plant extracts/natural products containing antioxidants with biological studies on various aspects and mechanisms of these components as inhibitors of inflammatory processes promoting carcinogenesis and/or antimicrobial agents.

Dr. Grażyna Zgórka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural radical scavengers
  • chemopreventive agents
  • antimicrobials
  • chemical and biomedical analysis
  • biological studies in vitro/in vivo

Published Papers (1 paper)

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Research

18 pages, 2932 KiB  
Article
Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients
by Annalisa Noce, Giulia Marrone, Manuela Di Lauro, Chiara Vita, Giulia Montalto, Gloria Giorgino, Carlo Chiaramonte, Cartesio D’Agostini, Sergio Bernardini and Massimo Pieri
Pharmaceuticals 2024, 17(4), 463; https://doi.org/10.3390/ph17040463 - 5 Apr 2024
Viewed by 2834
Abstract
Long coronavirus disease (COVID) syndrome leads to chronic inflammatory state onset that can have a multisystem impact and compromise organ function. Moreover, long COVID syndrome is often characterized by the presence of chronic fatigue, which affects subjects’ daily activities and worsens their quality [...] Read more.
Long coronavirus disease (COVID) syndrome leads to chronic inflammatory state onset that can have a multisystem impact and compromise organ function. Moreover, long COVID syndrome is often characterized by the presence of chronic fatigue, which affects subjects’ daily activities and worsens their quality of life. The aim of our double-blind, placebo-controlled randomized trial (protocol code RS 150.21, approved on 4 November 2021) was to evaluate the beneficial effects of the consumption of 2 cps/day, for two months, of an oral food supplement (OFS), based on Echinacea angustifolia, rosehip, propolis, royal jelly and zinc, in long COVID patients, compared to a two-month placebo period. The OFS’s vitamin C content was equal to 22.17 mg/g (8.87 mg/capsule). The OFS’s total polyphenol content was 43.98 mg/g gallic acid equivalents. At the end of the in vivo study, we highlighted a significant decrease in the inflammatory parameters in the OFS period, compared to the placebo period (neutrophil-to-lymphocyte ratio, p = 0.0455; monocyte to-lymphocyte ratio, p = 0.0005; C-reactive protein, p = 0.0145). Our study also highlighted a significant increase in vitamin D serum values (p = 0.0005) and, at the same time, an improvement in patients’ life quality and a reduction in fatigue, monitored by the fatigue severity scale. This study showed the OFS’s beneficial effects on the inflammatory state, fatigue and quality of life in long COVID patients. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. Dr. Annalisa Noce (University of Rome Tor Vergata, 00133 Rome, Italy)

2. Dr. Grażyna Zgórka (Medical University of Lublin, Collegium Universum, 1 Chodźki Street, 20-093 Lublin, Poland)

3. Dr. Ákos Jerzsele (University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary)

4. Dr. Stanislava Ivanova  (Medical University-Plovdiv, 4002 Plovdiv, Bulgaria)

5. Dr. Sanda Andrei (University of Agricultural Sciences and Veterinary Medicine Cluj Napoca, 400372 Cluj Napoca, Romania)

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