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Pharmaceuticals
Special Issues
Pharmacognosy and Phytotherapy: Natural Compounds from an Anti-aging Perspective 2024
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Pharmacognosy and Phytotherapy: Natural Compounds from an Anti-aging Perspective 2024

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 4695

Special Issue Editors

Dr. Geir Bjørklund

E-Mail Website
Guest Editor
Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway
Interests: biofactors; vitamins; minerals; trace elements; transition metals; toxic metals; metal interaction; chelating agents; chelation therapy; neurodegeneration; autism spectrum disorder; nutrition; nutritional biochemistry; peptides; polyphenols
Dr. Mariia Shanaida

E-Mail Website
Guest Editor
Department of Pharmacognosy and Medical Botany, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine
Interests: medicinal plants; phytochemistry; terpenoids; phenolic compounds; herbal drug development; natural products; nutraceuticals; antioxidants; biological activities
Special Issues, Collections and Topics in MDPI journals
Dr. Olha Mykhailenko

E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry, National University of Pharmacy, Kharkiv, Ukraine
Interests: secondary metabolism; natural products; chromatographic analysis; plant-environment interactions; plant biochemistry; GxP; agrochemistry

Special Issue Information

Dear Colleagues,

Undoubtedly, aging is a natural, evolutionarily programmed degenerative process characterized by functional impairments, tissue degeneration, cognitive deficits, and a senescent phenotype. Many external and internal factors can cause aging-related oxidative stress, including skin dryness and wrinkles, neurodegenerative disorders, atherosclerosis, diabetes, and cancer.

The true success of modern pharmaceutical and medical sciences in the field of prevention and treatment of diseases related to aging largely depends on drugs originally derived from natural sources. Herbal raw materials, seafood, beekeeping products, and many other natural substances have been used in traditional medicine to treat and prevent various human diseases since time immemorial.

In this Special Issue, we kindly invite you to join the scientific discussion of the latest achievements in the prevention and treatment of age-related disorders using natural compounds: from the theoretical aspects of promising constituents to discovering new natural drugs by involving the latest approaches and techniques. The comprehensive pharmaceutical analysis of natural anti-aging compounds could increase prospects for bringing them in the form of medicines to the pharmaceutical market.

This Special Issue aims to highlight the latest advances and the newest research to reveal the chemical structures of various natural substances which are promising for anti-aging applications as well as mechanisms and targets of their pharmacological actions.

We are looking forward to receiving your submissions.

Dr. Geir Bjørklund
Dr. Mariia Shanaida
Dr. Olha Mykhailenko
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • senescence
  • anti-aging compounds
  • natural products
  • medicinal plants
  • micronutrients
  • cosmetic ingredients
  • bioactive natural substances
  • antioxidant activity
  • pharmacological effect

Published Papers (2 papers)

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Research

20 pages, 4962 KiB  
Article
Effects of Water–Ethanol Extracts from Four Sphagnum Species on Gene Expression of Selected Enzymes in Normal Human Dermal Fibroblasts and Their Antioxidant Properties
by Maria Zych, Katarzyna Urbisz, Magdalena Kimsa-Dudek, Maria Kamionka, Sławomir Dudek, Barbara Klaudia Raczak, Stanisław Wacławek, Damian Chmura, Ilona Kaczmarczyk-Żebrowska and Adam Stebel
Pharmaceuticals 2023, 16(8), 1076; https://doi.org/10.3390/ph16081076 - 28 Jul 2023
Cited by 2 | Viewed by 1372
Abstract
Mosses (Bryophyta), particularly species of the genus Sphagnum, which have been used for centuries for the treatment of skin diseases and damage, are still not explored enough in terms of their use in cosmetics. The purpose of this study was to determine [...] Read more.
Mosses (Bryophyta), particularly species of the genus Sphagnum, which have been used for centuries for the treatment of skin diseases and damage, are still not explored enough in terms of their use in cosmetics. The purpose of this study was to determine the antioxidant properties of water–ethanol extracts from four selected species of the genus Sphagnum (S. girgenshonii Russow, S. magellanicum Brid., S. palustre L., and S. squarrosum Crome) and their impact on the expression of genes encoding key enzymes for the functioning of the skin. In this study, the effects of Sphagnum extracts on the expression of genes encoding tyrosinase, collagenase, elastase, hyaluronidase and hyaluronic acid synthase in human dermal fibroblasts were determined for the first time in vitro. The extracts inhibited tyrosinase gene expression and showed antioxidant activity. The experiment showed an increase in the expression of some genes encoding collagenase (MMP1) or hyaluronidase (HYAL2, HYAL3 and HYAL4) and a decrease in the hyaluronan synthase (HAS1, HAS2 and HAS3) genes expression by the tested extracts. The obtained results suggest that using extracts from the tested Sphagnum species in anti-aging cosmetics does not seem beneficial. Further studies are needed to clarify their impact on the skin. Full article
(This article belongs to the Special Issue Pharmacognosy and Phytotherapy: Natural Compounds from an Anti-aging Perspective 2024)
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16 pages, 2850 KiB  
Article
Investigation on the Biological Safety and Activity of a Gluconolactone-Based Lotion for Dermocosmetic Application
by Nicola Zerbinati, Serena Di Francesco, Maria Chiara Capillo, Cristina Maccario, Giorgio Stabile, Hassan Galadari, Raffaele Rauso, Sabrina Sommatis and Roberto Mocchi
Pharmaceuticals 2023, 16(5), 655; https://doi.org/10.3390/ph16050655 - 27 Apr 2023
Cited by 1 | Viewed by 2027
Abstract
(1) Background: Cosmeceuticals are formulas enriched with active ingredients that exert efficacy on different skin molecular targets. (2) Methods: Cell viability and the absence of potential irritant risk were evaluated on keratinocytes (HaCaT), fibroblasts (NHDF), adipocytes (3T3-L1), sebocytes (PCi-SEB_CAU) and reconstructed human epidermis [...] Read more.
(1) Background: Cosmeceuticals are formulas enriched with active ingredients that exert efficacy on different skin molecular targets. (2) Methods: Cell viability and the absence of potential irritant risk were evaluated on keratinocytes (HaCaT), fibroblasts (NHDF), adipocytes (3T3-L1), sebocytes (PCi-SEB_CAU) and reconstructed human epidermis (RHE), respectively. Several treatments were performed to evaluate the ability of the lotion to stimulate the production of collagen and elastin, stimulate the differentiation of keratinocytes and reduce the number of senescent cells following UVB stimulation. In addition, the modulation of genes involved in the production, storage and accumulation of sebum were investigated. (3) Results: The results obtained demonstrated the biosafety of the formula in all cell lines tested. The 24-h treatment with non-cytotoxic concentrations determined an increase in the expression of the collagen (COL1A1), elastin (ELN) and involucrin (IVL) genes, while a reduction of peroxisome proliferator-activated receptor-gamma (PPARγ) gene expression and a reduction of SA-βgal-positive cells were found. Moreover, the treatment did not interfere with normal steroid 5-alpha reductase (5RDA3) gene expression levels. (4) Conclusions: Data collected demonstrated the biosafety of the lotion, the non-comedogenic property and a multi targets anti-aging effect. In particular, data collected on the booster lotion make it a valid way to counteract the pore dilatation aging related. Full article
(This article belongs to the Special Issue Pharmacognosy and Phytotherapy: Natural Compounds from an Anti-aging Perspective 2024)
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