Special Issue "Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment 2.0"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 25 April 2024 | Viewed by 1447

Special Issue Editors

School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China
Interests: nanomedicine; biomaterials; drug/gene delivery; cancer immunotherapy; wound healing
Special Issues, Collections and Topics in MDPI journals
School of Life Sciences, Shanghai University, Shanghai, China
Interests: nanomaterials; nanomedicine; biomaterials; drug delivery; biomimetic; nanotechnology

Special Issue Information

Dear Colleagues,

Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to mankind. Effective cancer treatment is still a great challenge due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies. There is an urgent need for the discovery of novel therapeutic strategies with superior anticancer capabilities. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim at the targeted delivery of chemotherapeutic drugs to the tumor site, and utilize strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues; together, they lead to an improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.

This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy. In this regard, we would like to invite authors to contribute original papers or comprehensive reviews on the development and possible applications of nanomedicines for cancer therapy.

Dr. Huijie Zhang
Dr. Shini Feng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer therapy
  • drug delivery
  • targeted delivery
  • nanocarriers
  • nanoparticles
  • controlled release
  • tumor targeting

Published Papers (1 paper)

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Review

35 pages, 2848 KiB  
Review
Liposomes for the Treatment of Brain Cancer—A Review
Pharmaceuticals 2023, 16(8), 1056; https://doi.org/10.3390/ph16081056 - 25 Jul 2023
Cited by 3 | Viewed by 1302
Abstract
Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release [...] Read more.
Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consolidate relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes. The paper first briefly explains conventional treatment modalities for cancer, followed by describing the blood–brain barrier and ways, challenges, and techniques involved in transporting drugs across the BBB. Various nanocarrier systems are introduced, with attention to liposomes, due to their ability to circumvent the challenges imposed by the BBB. Relevant studies involving liposomal systems researched to treat brain tumors are reviewed in vitro, in vivo, and clinical studies. Finally, the challenges associated with the use of liposomes to treat brain tumors and how they can be addressed are presented. Full article
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