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Pharmaceuticals
Special Issues
Interaction between Nanoparticles and Antibiotics：Against Antimicrobial Resistance
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Interaction between Nanoparticles and Antibiotics：Against Antimicrobial Resistance

A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: 22 August 2024 | Viewed by 2160

Special Issue Editors

Dr. Isabella Macário Ferro Cavalcanti

E-Mail Website
Guest Editor
1. Laboratory of Clinical Microbiology, Keizo Asami Institute (iLIKA), Federal University of Pernambuco (UFPE), Recife 50670-901, Brazil
2. Laboratory of Microbiology and Immunology, Academic Center of Vitória (CAV), Federal University of Pernambuco (UFPE), Recife 55608-680, Brazil
Interests: nanotechnology; antimicrobial resistance; drugs
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Carolina Accioly Brelaz de Castro

E-Mail Website
Guest Editor
1. Laboratory of Parasitology , Academic Center of Vitória (CAV), R. Alto do Reservatório - Alto José Leal, Federal University of Pernambuco (UFPE), Recife 55608-680, Brazil
2. Immunology Department, Aggeu Magalhães Institute, Campus da UFPE, Av. Prof. Moraes Rego, s/n - Cidade Universitária, Recife 50740-465, Brazil
Interests: flow cytometry; parasitology; immunology

Special Issue Information

Dear Colleagues,

Over the past decade, microbial infections have been described as a frequent cause of morbidity and mortality and are already considered a worldwide public health problem. Furthermore, infections caused by multidrug-resistant (MDR) microorganisms (bacteria, fungi, and parasites) have been worrying the scientific community, as estimates indicate that the number of deaths caused by them will increase to 10 million by 2050. The increasing inefficacy of current drugs for these infections is putting the achievements of modern medicine at risk. In this context, pharmaceutical nanotechnology appears to be a promising alternative. Pharmaceutical nanotechnology allows the encapsulation of drugs in nanocarriers. These systems can direct the molecules to the target sites, in addition to promoting their controlled release, increasing the time of permanence of the drug in the body and maintaining a constant concentration of the drug in the therapeutic range. In addition, the encapsulation of drugs in drug delivery systems (DDSs) can potentiate the therapeutic effect of the drug, increase the bioavailability of this drug, reduce its toxicity, minimize the number of administrations and adverse effects, and improve the patient's adherence to therapy. Based on these findings, we invite researchers to contribute articles in interaction between nanoparticles and antibiotics against antimicrobial resistance.

Dr. Isabella Macário Ferro Cavalcanti
Dr. Maria Carolina Accioly Brelaz de Castro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microorganisms
  • resistance
  • pharmaceutical research
  • nanotechnology

Published Papers (2 papers)

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Research

14 pages, 5650 KiB  
Article
Glycyrrhizic Acid Nanoparticles Subside the Activity of Methicillin-Resistant Staphylococcus aureus by Suppressing PBP2a
by Patricia Rijo, Tamer M. M. Abuamara, Lashin Saad Ali Lashin, Sherif A. Kamar, Vera M. S. Isca, Tahseen S. Mohammed, Mohamed S. M. Abdrabo, Mohamed A. Amin, Ahmed I. Abd El Maksoud and Amr Hassan
Pharmaceuticals 2024, 17(5), 589; https://doi.org/10.3390/ph17050589 - 06 May 2024
Viewed by 179
Abstract
Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) are classified as high-risk infections that can lead to death, particularly among older individuals. Nowadays, plant nanoparticles such as glycyrrhizic acid are recognized as efficient bactericides against a wide range of bacterial strains. Recently, scientists have [...] Read more.
Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) are classified as high-risk infections that can lead to death, particularly among older individuals. Nowadays, plant nanoparticles such as glycyrrhizic acid are recognized as efficient bactericides against a wide range of bacterial strains. Recently, scientists have shown interest in plant extract nanoparticles, derived from natural sources, which can be synthesized into nanomaterials. Interestingly, glycyrrhizic acid is rich in antioxidants as well as antibacterial agents, and it exhibits no adverse effects on normal cells. In this study, glycyrrhizic acid nanoparticles (GA-NPs) were synthesized using the hydrothermal method and characterized through physicochemical techniques such as UV–visible spectrometry, DLS, zeta potential, and TEM. The antimicrobial activity of GA-NPs was investigated through various methods, including MIC assays, anti-biofilm activity assays, ATPase activity assays, and kill-time assays. The expression levels of mecA, mecR1, blaR1, and blaZ genes were measured by quantitative RT-qPCR. Additionally, the presence of the penicillin-binding protein 2a (PBP2a) protein of S. aureus and MRSA was evaluated by a Western blot assay. The results emphasized the fabrication of GA nanoparticles in spherical shapes with a diameter in the range of 40–50 nm. The data show that GA nanoparticles exhibit great bactericidal effectiveness against S. aureus and MRSA. The treatment with GA-NPs remarkably reduces the expression levels of the mecA, mecR1, blaR1, and blaZ genes. PBP2a expression in MRSA was significantly reduced after treatment with GA-NPs. Overall, this study demonstrates that glycyrrhizic acid nanoparticles have potent antibacterial activity, particularly against MRSA. This research elucidates the inhibition mechanism of glycyrrhizic acid, which involves the suppressing of PBP2a expression. This work emphasizes the importance of utilizing plant nanoparticles as effective antimicrobial agents against a broad spectrum of bacteria. Full article
(This article belongs to the Special Issue Interaction between Nanoparticles and Antibiotics：Against Antimicrobial Resistance)
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31 pages, 5674 KiB  
Article
Ceftazidime/Tobramycin Co-Loaded Chitosan-Coated Zein Nanoparticles against Antibiotic-Resistant and Biofilm-Producing Pseudomonas aeruginosa and Klebsiella pneumoniae
by Luís André de Almeida Campos, Azael Francisco Silva Neto, Alexsandra Maria Lima Scavuzzi, Ana Catarina De Souza Lopes, Nereide Stela Santos-Magalhães and Isabella Macário Ferro Cavalcanti
Pharmaceuticals 2024, 17(3), 320; https://doi.org/10.3390/ph17030320 - 29 Feb 2024
Viewed by 1310
Abstract
This study aimed to co-encapsulate ceftazidime and tobramycin in zein nanoparticles coated with chitosan and to characterize and evaluate the antibacterial and antibiofilm activity against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae. Zein nanoparticles, synthesized using the nanoprecipitation method, were characterized by their [...] Read more.
This study aimed to co-encapsulate ceftazidime and tobramycin in zein nanoparticles coated with chitosan and to characterize and evaluate the antibacterial and antibiofilm activity against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae. Zein nanoparticles, synthesized using the nanoprecipitation method, were characterized by their particle size (Ø), polydispersity index (PDI), zeta potential (ζ), pH, and encapsulation efficiency (%EE). The chitosan coating provided stability, and physicochemical analyses revealed chemical interactions, efficient drug encapsulation, and thermal stability. The release kinetics demonstrated controlled release in simulated gastric and intestinal pH. The antibacterial activity, assessed by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), indicated effectiveness against both pathogens. Antibiofilm assays, conducted using the crystal violet method, demonstrated the inhibition and eradication of biofilms. The chitosan-coated zein nanoparticles with CAZ and/or TOB exhibited Ø (315–335 nm), PDI (<0.2), ζ (+40 to +50 mV), pH (5), and %EE (>55%). Notably, the co-encapsulation formulation (CAZ–TOB–ZNP–CH) showed enhanced antibacterial and antibiofilm activities compared to the individual formulations. These findings suggest that the developed nanoparticles present a promising alternative for treating respiratory and intestinal infections caused by antibiotic-resistant and biofilm-producing P. aeruginosa and K. pneumoniae. Full article
(This article belongs to the Special Issue Interaction between Nanoparticles and Antibiotics：Against Antimicrobial Resistance)
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