Drug Discovery of Antiprotozoal Agents 2024
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 131
Special Issue Editors
Interests: drug design; neglected diseases; antimicrobial; anti-cancer
Special Issues, Collections and Topics in MDPI journals
Interests: design, synthesis and biological evaluation of heterocyclic compounds for therapeutic purposes (mycology, parasitology, bacteriology and cancer); inhibitors of kinase signaling pathways; ADMET properties of molecules of biological interest
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protozoan diseases continue to represent a serious worldwide health problem, causing serious social and economic impacts, especially in developing countries. Protozooses such as malaria, leishmaniasis, trypanosomiasis, toxoplasmosis, trichomoniasis, giardiasis, and amoebiasis are responsible for high mortality and morbidity rates, potentially affecting more than 1 billion people worldwide.
Globally, the endemicity of these diseases has increased due to several factors, including low investments in research in the search for new drugs with novel mechanisms of action, a lack of effective drugs with low adverse effects and low toxicity, the increase in drug resistance, and the increasing appearance of cross resistance (which has made the few therapeutic options ineffective in many cases).
This problem has led many researchers to seek new antiprotozoal drugs through different scientific approaches, mainly based on two axes: (1) the isolation and identification of drug candidates through the bioprospection of natural resources (plants, animals, and microorganisms) and (2) drug design based on the use of medicinal chemistry tools, involving synthetic chemistry procedures, associated or not with computational approaches (structure-based drug discovery and ligand-based drug discovery).
In this Special Issue, authors are invited to submit reviews and original articles related to recent research centred around the drug design and discovery, synthesis, and pharmacological properties (in vitro and in vivo) of natural products and/or synthetic compounds that have the potential to become drug candidates for protozoan diseases. As well as presenting the latest advances in the search for pharmacological targets for protozoan diseases, we aimed to provide researchers with the most up-to-date information in this field.
Potential topics include, but are not limited to, the following:
- Bioprospecting of natural products;
- Drug design and discovery;
- Synthesis;
- Computational methods (ADMET, CADD, LBDD, SBDD, QSAR, and VS);
- In vitro and in vivo evaluations;
- Recent advances in antiprotozoal drugs;
Prof. Dr. Francisco Jaime Bezerra Mendonça Júnior
Prof. Dr. Pascal Marchand
Guest Editors
Manuscript Submission Information
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Keywords
- antiprotozoal agents
- drug discovery
- medicinal chemistry
- natural products
- in vitro and in vivo studies
- ADMET
- computer-aided drug design
- chemoinformatics
- molecular docking
- virtual screening
Related Special Issue
- Drug Discovery of Antiprotozoal Agents in Pharmaceuticals (12 articles)
