Hydrogels for Pharmaceutical and Biomedical Applications 2024

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 25 June 2024 | Viewed by 2374

Special Issue Editors


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Guest Editor
Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo 162-8601, Japan
Interests: hydrogel; pharmaceutical applications; bio medical applications; drug delivery system; tissue engineering
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
Interests: pre-formulation; solid dispersion; hydrogel; wound healing; semi-solid formulation; prevention of stomatitis; nanoparticle; grinding; DSC; PXRD
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogels are hydrophilic and have three-dimensional cross-linked structures that absorb or retain large amounts of water or biological fluids, forming aqueous, semi-solid/solid gel networks. Furthermore, they are also insoluble due to chemical and/or physical crosslinks. The main features of hydrogels are similar, both compositionally and mechanically, to those of native extracellular matrices, as they have a soft material nature, and their hydrophilic and cross-linked properties impart biocompatibility, meaning that they have been widely used in applications in pharmaceutical and medical fields; for example, as drug carriers in drug delivery systems and as materials for cells during tissue regeneration, and so on.

In recent years, 3D printing systems that utilize biopolymers have been developed; these systems can create various hydrogels for use in biological tissues. Hydrogels can uptake water and form hydrated yet solid materials that are similar to cells in the human body. In addition, many polymers are used to prepare hydrogels that have mucoadhesive and bioadhesive characteristics.

Hence, hydrogels have many possible applications beyond the pharmaceutical and medical fields in regenerative medicine and tissue engineering.

This Special Issue of Pharmaceuticals invites the submission of both reviews and original articles regarding the use of hydrogels in pharmaceutical and biomedical applications. Topics of interest include the preparation and evaluation of hydrogels (physicochemical properties, in vivo studies, etc.), clinical trials for new formulations, etc.

Dr. Yayoi Kawano
Dr. Takehisa Hanawa
Guest Editors

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Keywords

  • hydrogel
  • pharmaceutical applications
  • biomedical applications
  • drug delivery system
  • tissue engineering

Published Papers (3 papers)

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Research

11 pages, 809 KiB  
Article
Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid Plus Calcium Hydroxyapatite in the Treatment of Stress Urinary Incontinence
by Piotr Kolczewski, Mariusz Łukaszuk, Aneta Cymbaluk-Płoska, Mateusz Kozłowski, Sylwester Ciećwież, Rafał Kuźlik and Nicola Zerbinati
Pharmaceuticals 2024, 17(5), 622; https://doi.org/10.3390/ph17050622 - 11 May 2024
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Abstract
Background: Stress urinary incontinence (SUI) causes both physical and psychological problems to women and their partners. Recently, vaginal radiofrequency (RF) application, as well as the administration of non-crosslinked hyaluronic acid (NCLHA) together with calcium hydroxyapatite (CaHA), has attracted attention for SUI treatment. The [...] Read more.
Background: Stress urinary incontinence (SUI) causes both physical and psychological problems to women and their partners. Recently, vaginal radiofrequency (RF) application, as well as the administration of non-crosslinked hyaluronic acid (NCLHA) together with calcium hydroxyapatite (CaHA), has attracted attention for SUI treatment. The current, comparative study evaluated the efficacy and safety of these technologies acting separately and in a combined treatment. Methods: Sixty women with mild to moderate SUI, aged between 46 and 76 years (mean age 63.2) were divided into three groups intended for different treatments: group I, RF vaginal treatment only, group II, NCLHA plus CaHA periurethral injection only, group III, combined treatment including a single periurethral injection of NCLHA plus CaHA followed by four vaginal applications of RF at intervals of 3–5 days. The clinical effects of the treatments were evaluated by ICIQ-LUTSqol (Polish version) and UDI-6. Results: The obtained results suggest that the symptoms of SUI and the quality of life of the patients improved significantly in each group after the therapies compared to the pre-treatment levels and were more persistent in the third HA + RF group compared to the HA or the RF group. Full article
(This article belongs to the Special Issue Hydrogels for Pharmaceutical and Biomedical Applications 2024)
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29 pages, 8076 KiB  
Article
Characterization, Biocompatibility and Antioxidant Activity of Hydrogels Containing Propolis Extract as an Alternative Treatment in Wound Healing
by Lindalva Maria de Meneses Costa Ferreira, Yuri Yoshioka Modesto, Poliana Dimsan Queiroz de Souza, Fabiana Cristina de Araújo Nascimento, Rayanne Rocha Pereira, Attilio Converti, Desireé Gyles Lynch, Davi do Socorro Barros Brasil, Edilene Oliveira da Silva, José Otávio Carréra Silva-Júnior and Roseane Maria Ribeiro-Costa
Pharmaceuticals 2024, 17(5), 575; https://doi.org/10.3390/ph17050575 - 30 Apr 2024
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Abstract
Hydrogels consist of a network of highly porous polymeric chains with the potential for use as a wound dressing. Propolis is a natural product with several biological properties including anti-inflammatory, antibacterial and antioxidant activities. This study was aimed at synthesizing and characterizing a [...] Read more.
Hydrogels consist of a network of highly porous polymeric chains with the potential for use as a wound dressing. Propolis is a natural product with several biological properties including anti-inflammatory, antibacterial and antioxidant activities. This study was aimed at synthesizing and characterizing a polyacrylamide/methylcellulose hydrogel containing propolis as an active ingredient, to serve as a wound dressing alternative, for the treatment of skin lesions. The hydrogels were prepared using free radical polymerization, and were characterized using scanning electron microscopy, infrared spectroscopy, thermogravimetry, differential scanning calorimetry, swelling capacity, mechanical and rheological properties, UV-Vis spectroscopy, antioxidant activity by the DPPH, ABTS and FRAP assays and biocompatibility determined in Vero cells and J774 macrophages by the MTT assay. Hydrogels showed a porous and foliaceous structure with a well-defined network, a good ability to absorb water and aqueous solutions simulating body fluids as well as desirable mechanical properties and pseudoplastic behavior. In hydrogels containing 1.0 and 2.5% propolis, the contents of total polyphenols were 24.74 ± 1.71 mg GAE/g and 32.10 ± 1.01 mg GAE/g and those of total flavonoids 8.01 ± 0.99 mg QE/g and 13.81 ± 0.71 mg QE/g, respectively, in addition to good antioxidant activity determined with all three methods used. Therefore, hydrogels containing propolis extract, may serve as a promising alternative wound dressing for the treatment of skin lesions, due to their anti-oxidant properties, low cost and availability. Full article
(This article belongs to the Special Issue Hydrogels for Pharmaceutical and Biomedical Applications 2024)
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34 pages, 24442 KiB  
Article
Cytocompatibility, Antimicrobial and Antioxidant Activity of a Mucoadhesive Biopolymeric Hydrogel Embedding Selenium Nanoparticles Phytosynthesized by Sea Buckthorn Leaf Extract
by Naomi Tritean, Luminița Dimitriu, Ștefan-Ovidiu Dima, Rusăndica Stoica, Bogdan Trică, Marius Ghiurea, Ionuț Moraru, Anisoara Cimpean, Florin Oancea and Diana Constantinescu-Aruxandei
Pharmaceuticals 2024, 17(1), 23; https://doi.org/10.3390/ph17010023 - 22 Dec 2023
Cited by 2 | Viewed by 1176
Abstract
Phytosynthesized selenium nanoparticles (SeNPs) are less toxic than the inorganic salts of selenium and show high antioxidant and antibacterial activity. Chitosan prevents microbial biofilm formation and can also determine microbial biofilm dispersal. Never-dried bacterial nanocellulose (NDBNC) is an efficient carrier of bioactive compounds [...] Read more.
Phytosynthesized selenium nanoparticles (SeNPs) are less toxic than the inorganic salts of selenium and show high antioxidant and antibacterial activity. Chitosan prevents microbial biofilm formation and can also determine microbial biofilm dispersal. Never-dried bacterial nanocellulose (NDBNC) is an efficient carrier of bioactive compounds and a flexible nanofibrillar hydrophilic biopolymer. This study aimed to develop a selenium-enriched hydrogel nanoformulation (Se-HNF) based on NDBNC from kombucha fermentation and fungal chitosan with embedded biogenic SeNPs phytosynthesized by an aqueous extract of sea buckthorn leaves (SbLEx)—SeNPsSb—in order to both disperse gingival dysbiotic biofilm and prevent its development. We determined the total phenolic content and antioxidant activity of SbLEx. Liquid chromatography–mass spectrometry (LC-MS) and high-performance liquid chromatography (HPLC) were used for the identification of polyphenols from SbLEx. SeNPsSb were characterized by transmission electron microscopy–energy-dispersive X-ray spectroscopy (TEM-EDX), dynamic light scattering (DLS), zeta potential, Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) in small- and wide-angle X-ray scattering (SAXS and WAXS). The hydrogel nanoformulation with embedded SeNPsSb was characterized by SEM, FTIR, XRD, rheology, mucin binding efficiency, contact angle and interfacial tension measurements. We also assessed the in vitro biocompatibility, antioxidant activity and antimicrobial and antibiofilm potential of SeNPsSb and Se-HNF. TEM, DLS and SAXS evidenced polydisperse SeNPsSb, whereas FTIR highlighted a heterogeneous biocorona with various biocompounds. The contact angle on the polar surface was smaller (52.82 ± 1.23°) than that obtained on the non-polar surface (73.85 ± 0.39°). The interfacial tension was 97.6 ± 0.47 mN/m. The mucin binding efficiency of Se-HNF decreased as the amount of hydrogel decreased, and the SEM analysis showed a relatively compact structure upon mucin contact. FTIR and XRD analyses of Se-HNF evidenced an interaction between BNC and CS through characteristic peak shifting, and the rheological measurements highlighted a pseudoplastic behavior, 0.186 N adhesion force and 0.386 adhesion energy. The results showed a high degree of cytocompatibility and the significant antioxidant and antimicrobial efficiency of SeNPsSb and Se-HNF. Full article
(This article belongs to the Special Issue Hydrogels for Pharmaceutical and Biomedical Applications 2024)
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