Special Issue "Recent Advances in Natural Product Based Nanostructured Systems"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 25 January 2024 | Viewed by 3815

Special Issue Editors

Special Issue Information

Dear Colleagues,

Nanotechnology has presented innovative solutions to many of humanity’s needs over the last few decades. Medicine, environmental sanitation, engineering, power generation, agriculture, and many other fields have benefited from nano-based solutions. However, the continuous development of nanotechnology depends on high-performance materials. In this regard, nature is an incredibly rich source of chemical compounds, many of which can be used either to design new products or to replace non-sustainable materials in products and processes. Natural compounds are not only intrinsically sustainable but can also present superior biocompatibility, enhanced effectiveness and better safety. The use of these compounds in nanotechnology can be also inspired by their in situ role in the organisms from which they are derived. Indeed, many naturally occurring nanostructures, such as films, membranes, vesicles, and viruses, are based on biomolecules specially selected over millions of years of biological evolution for performing their function at the nanoscale. Moreover, many drugs and other bioactive compounds derived from natural sources can be loaded into nanosystems in order to achieve enhanced effectiveness and safety. Therefore, this Special Issue entitled "Recent Advances in Natural Product-Based Nanostructured Systems" is dedicated to collecting works on: 1) biomimetic and bioinspired nanostructures; 2) green nanotechnology; and 3) nanocarriers for bioactive compounds.

Dr. Luís Alexandre Muehlmann
Dr. João Paulo Longo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

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Published Papers (2 papers)

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Review

16 pages, 1061 KiB  
Review
Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention and Treatment of Diabetes Mellitus and Its Complications
Pharmaceuticals 2023, 16(5), 736; https://doi.org/10.3390/ph16050736 - 12 May 2023
Cited by 1 | Viewed by 1484
Abstract
Diabetes mellitus (DM) is a metabolic disease characterized by abnormal blood glucose levels-hyperglycemia, caused by a lack of insulin secretion, impaired insulin action, or a combination of both. The incidence of DM is increasing, resulting in billions of dollars in annual healthcare costs [...] Read more.
Diabetes mellitus (DM) is a metabolic disease characterized by abnormal blood glucose levels-hyperglycemia, caused by a lack of insulin secretion, impaired insulin action, or a combination of both. The incidence of DM is increasing, resulting in billions of dollars in annual healthcare costs worldwide. Current therapeutics aim to control hyperglycemia and reduce blood glucose levels to normal. However, most modern drugs have numerous side effects, some of which cause severe kidney and liver problems. On the other hand, natural compounds rich in anthocyanidins (cyanidin, delphinidin, malvidin, pelargonidin, peonidin, and petunidin) have also been used for the prevention and treatment of DM. However, lack of standardization, poor stability, unpleasant taste, and decreased absorption leading to low bioavailability have hindered the application of anthocyanins as therapeutics. Therefore, nanotechnology has been used for more successful delivery of these bioactive compounds. This review summarizes the potential of anthocyanins for the prevention and treatment of DM and its complications, as well as the strategies and advances in the delivery of anthocyanins using nanoformulations. Full article
(This article belongs to the Special Issue Recent Advances in Natural Product Based Nanostructured Systems)
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19 pages, 2092 KiB  
Review
Research Progress of Bioinspired Nanostructured Systems for the Treatment of Ocular Disorders
Pharmaceuticals 2023, 16(1), 96; https://doi.org/10.3390/ph16010096 - 10 Jan 2023
Viewed by 1793
Abstract
How to enhance the bioavailability and prolong the residence time of drugs in the eye present the major barriers to traditional eye delivery. Nanotechnology has been widely used in ocular drug delivery systems because of its advantages of minimizing adverse reactions, decreasing the [...] Read more.
How to enhance the bioavailability and prolong the residence time of drugs in the eye present the major barriers to traditional eye delivery. Nanotechnology has been widely used in ocular drug delivery systems because of its advantages of minimizing adverse reactions, decreasing the frequency of administration, prolonging the release time, and improving the bioavailability of the drug in the eye. As natural product-based nanostructured systems, bioinspired nanostructured systems have presented as less toxic, easy to prepare, and cost-effective and have potential application value in the field of nanotechnology. A systematic classification of bioinspired nanostructured systems based on their inspiration source and formulation and their brief applications in disease are presented here. A review of recent research progress of the bioinspired nanostructured systems for the treatment of the anterior and posterior segment of ocular disorders is then presented in detail. Finally, current challenges and future directions with regard to manufacturing bioinspired nanomaterials are provided. Full article
(This article belongs to the Special Issue Recent Advances in Natural Product Based Nanostructured Systems)
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