Recent Advances in Targeted Protein Degradation
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 6613
Special Issue Editors
Interests: PROTACs; senolytics; epigenetics apoptosis; targeted drug delivery
Special Issue Information
Dear Colleagues,
Targeted protein degradation (TPD), an efficient strategy to reversibly eliminate dysfunctional proteins, is emerging as a game-changing remedy for the clinical treatment of various diseases. Proximity-based protein degraders include PROTACs and molecular glues that recruit E3 ubiquitin ligase in close proximity to the target protein and therefore induce the degradation of the target protein via the proteasomal system, and LYTACs and AUTACs that trigger protein degradation via the lysosome and autophagy, separately. The rapid development of protein degraders with different proteolytic machinery expands their potential applications.
This Special Issue of Molecules aims to present the most recent advances in the TPD field. Herein, we welcome original research articles and reviews that cover, but are not limited to, the following topics: chemical and biological studies for the rational design and optimization of protein degraders or their prodrugs; synthetic approaches for assembling of heterobifunctional molecules; identification of new ligands for E3 ubiquitin ligase.
Dr. Xuan Zhang
Dr. Xingui Liu
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- targeted protein degradation
- protein degraders
- PROTAC
- molecular glue
- LYTAC
- AUTAC
- prodrug
- E3 ubiquitin ligase
