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Progress in Metal Catalysis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 4994

Special Issue Editors

School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
Interests: selenium; maleimide; difunctionalization; copper-catalyzed; cascade reaction
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Guest Editor
College of Chemical Engineering and Technology, Hainan University, Haikou 570228, China
Interests: developing new synthetic methods and elucidating the associated mechanisms; green synthesis of phosphorus compounds and transformations of carboxylic derivatives

Special Issue Information

Dear Colleagues,

Metal-catalysis undertakes the significant task of creating new substances, new structures and new functions. It is the core and foundation of chemical science and has always been at the forefront of the development of chemical science. Every time chemists add a new tool of metal-catalysis to the "toolbox", the fineness of molecular construction is further improved. At present, more than 90% of the world's industrial chemicals involve chemical catalysis in the production process, and about 35% of the world's GDP involves chemical catalysis to some extent. With the help of metal catalysts, the process of drug production is simplified and the efficiency is greatly improved. At the same time, the Nobel prize also favors metal catalysis. For example, in 2001, the Nobel Prize in chemistry was awarded to "chiral catalytic hydrogenation and oxidation"; in 2010, Pd-catalyzed cross coupling reaction was also awarded. The birth of metal-catalysis has unprecedentedly improved the ability and level of chemists to manipulate atoms and molecules. Metal catalysis not only solves the problems in the process of compound synthesis but also promotes molecular drug manufacturers to develop a new generation of drugs. For example, 15% ~ 30% of the compounds currently being developed by AstraZeneca are metal-catalyzed methods. Gleevec, Valsartan, Boscalid, Prosulfuron and Cyclotene are only some of the achievements of metal catalysis. Therefore, the significance of metal catalysis is not only on paper but also further invested in the great cause of national production and building socialism, which is beneficial to the country and the people.

This Special Issue aims to collect scientific papers with metal-catalysis works. The most remarkable feature of metal catalysis is that it has strong creativity. It can not only create substances already existing in nature, but it can also create new substances with ideal properties and functions that do not exist in nature. Through the intersection and integration with other disciplines, metal-catalysis has produced many new interdisciplinary and cutting-edge fields, which provide new opportunities for the development of metals. At the same time, it also puts forward higher requirements for metal catalysis itself in different space–time scales in order to explore its infinite possibilities.

Dr. Ge Wu
Prof. Dr. Tieqiao Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cross-coupling Reaction
  • C-H Activation
  • CO2 Utilization
  • Asymmetric Synthesis
  • Cascade Reaction
  • Multi-Component Reaction
  • Domino Reaction
 

Published Papers (3 papers)

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Research

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14 pages, 1340 KiB  
Article
Palladium-Catalyzed N-Alkenylation of N-Aryl Phosphoramidates with Alkenes
by Yu-An Li, Ge Wu and Jia Li
Molecules 2023, 28(11), 4466; https://doi.org/10.3390/molecules28114466 - 31 May 2023
Viewed by 1007
Abstract
Versatile and concise Pd-catalyzed oxidative N-alkenylation of N-aryl phosphoramidates with alkenes is described in this study, a reaction that is of great significance but surprisingly unexploited. The transformation proceeds under mild reaction conditions, using O2 as a green oxidant and [...] Read more.
Versatile and concise Pd-catalyzed oxidative N-alkenylation of N-aryl phosphoramidates with alkenes is described in this study, a reaction that is of great significance but surprisingly unexploited. The transformation proceeds under mild reaction conditions, using O2 as a green oxidant and TBAB as an effective additive. An efficient catalytic system allows a variety of drug-related substrates to participate in these transformations, which is of great interest in the drug discovery and development of phosphoramidates. Full article
(This article belongs to the Special Issue Progress in Metal Catalysis)
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14 pages, 3578 KiB  
Article
Synergistic Catalysis in Heterobimetallic Complexes for Homogeneous Carbon Dioxide Hydrogenation
by Zeno B. G. Fickenscher, Peter Lönnecke, Anna K. Müller, Oldamur Hollóczki, Barbara Kirchner and Evamarie Hey-Hawkins
Molecules 2023, 28(6), 2574; https://doi.org/10.3390/molecules28062574 - 12 Mar 2023
Cited by 5 | Viewed by 1723
Abstract
Two heterobimetallic Mo,M’ complexes (M’ = IrIII, RhIII) were synthesized and fully characterized. Their catalytic activity in homogeneous carbon dioxide hydrogenation to formate was studied. A pronounced synergistic effect between the two metals was found, most notably between Mo [...] Read more.
Two heterobimetallic Mo,M’ complexes (M’ = IrIII, RhIII) were synthesized and fully characterized. Their catalytic activity in homogeneous carbon dioxide hydrogenation to formate was studied. A pronounced synergistic effect between the two metals was found, most notably between Mo and Ir, leading to a fourfold increase in activity compared with a binary mixture of the two monometallic counterparts. This synergism can be attributed to spatial proximity of the two metals rather than electronic interactions. To further understand the nature of this interaction, the mechanism of the CO2 hydrogenation to formate by a monometallic IrIII catalyst was studied using computational and spectroscopic methods. The resting state of the reaction was found to be the metal-base adduct, whereas the rate-determining step is the inner-sphere hydride transfer to CO2. Based on these findings, the synergism in the heterobimetallic complex is beneficial in this key step, most likely by further activating the CO2. Full article
(This article belongs to the Special Issue Progress in Metal Catalysis)
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Review

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25 pages, 15018 KiB  
Review
Copper-Catalyzed Difluoroalkylation Reaction
by Dao-Qing Dong, Shao-Hui Yang, Pei Wu, Jin-Zhi Wang, Ling-Hao Min, Hao Yang, Meng-Yu Zhou, Ze-Hui Wei, Cai-Zhen Ding, Yan-Li Wang, Jia-Hui Gao, Shu-Jie Wang and Zu-Li Wang
Molecules 2022, 27(23), 8461; https://doi.org/10.3390/molecules27238461 - 02 Dec 2022
Cited by 6 | Viewed by 1725
Abstract
This review describes recent advances in copper-catalyzed difluoroalkylation reactions. The RCF2 radical is generally proposed in the mechanism of these reactions. At present, various types of copper-catalyzed difluoroalkylation reactions have been realized. According to their characteristics, we classify these difluoroalkylation reactions into [...] Read more.
This review describes recent advances in copper-catalyzed difluoroalkylation reactions. The RCF2 radical is generally proposed in the mechanism of these reactions. At present, various types of copper-catalyzed difluoroalkylation reactions have been realized. According to their characteristics, we classify these difluoroalkylation reactions into three types. Full article
(This article belongs to the Special Issue Progress in Metal Catalysis)
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