Special Issue "Can Membrane Transporters Contribute to Drug Discovery?"
Deadline for manuscript submissions: closed (30 January 2017) | Viewed by 58865
2. Laboratory of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: medicinal chemistry; organic synthesis; heterocycles; P-glycoprotein; anticancer; antimicrobials; chiral drugs; marine natural products
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Membrane transporters are experiencing a renascence. Two families of transporters, the ATP-binding cassette (ABC) and the solute carrier (SLC) transporters, contribute to the efficacy and safety of drugs in the drug development process. The question for this Special Issue of Molecules is “Can membrane transporters contribute to drug discovery?”. We know that many transporters are implicated in human diseases, mainly by affecting endogenous substances and/or drug disposition; such is the case of P-glycoprotein, which has been an “old target” for multidrug resistance and is now being considered for treatment of Alzheimer’s disease.
This Special Issue intends to collect the state-of-the-art in original research and review articles that consider ABC and SLC modulators as potential drug candidates. Select topics are: Membrane transporters in cancer, membrane transporters and antimicrobial resistance, membrane transporters and metabolic disorders, membrane transporters and CNS, membrane transporters and signaling and their role in medicinal chemistry, membrane transporters in detoxifying xenobiotics. You are welcome to generate a unique topic.
Prof. Maria Emília de Sousa
Manuscript Submission Information
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- ATP-binding cassette transporters
- solute carrier transporters
- pharmacological targets
- drug discovery
- drug disposition