Current Trends in Application of Cytosine-rich Oligonucleotides
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 September 2022)
Special Issue Editors
Interests: G-quadruplex; DNAzyme; DNA probes; Bioassay development; bioanalysis
Special Issues, Collections and Topics in MDPI journals
Interests: G-quadruplex; i-motif; DNA probes; DNA-templated silver nanoclusters Bioassay development; bioanalysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Functional nucleic acids are very attractive in terms of their applications in biotechnology and nanotechnology. Among many different types of functional nucleic acids, there is growing interest in cytosine-rich oligonucleotides. A characteristic feature of oligonucleotides rich in cytosine (C-rich) is their ability to fold into a tetraplex called I-motif proceeded by cytosine protonation. The pH-dependent I-motif formation has found applications in many areas, i.e., in the design of molecular sensing devices, nanomachines, nanoswitches, electrodes, and other intelligent nanosurfaces or nanomaterials. Moreover, C-rich oligonucleotides can promote triplex structure formation and serve as efficient templates for fluorescent silver nanoclusters (AgNCs). On the other hand, C-rich sequences have been found in eukaryotic genomes, and some proteins can selectively bind I-motif structures; therefore, such sequences are biologically relevant. Recent trends concerning C-rich oligonucleotides as well as other functional nucleic acids include the diagnostic and therapeutic applications of this kind of biomaterials. This Special Issue aims to provide an opportunity to share new knowledge, developments, and applications of cytosine-rich functional nucleic acids.
Prof. Dr. Bernard Juskowiak
Dr. Anna Renata Dembska
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Cytosine-rich oligonucleotide
- I-motif
- pH sensors
- Silver nanoclusters
- AgNCs
- Nanocontainers
- Molecular logic gates
- Fluorescence probes
- Triplex
