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Anti-inflammatory Activity of Natural Products and Alternative Medicine: 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 978

Special Issue Editors


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Guest Editor
Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, Republic of Korea
Interests: natural products; atopic dermatitis; contact dermatitis; allergy; asthma; chronic obstructive pulmonary disease (COPD)
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Interests: natural products; inflammatory bowel disease; colorectal cancer; ulcerative colitis; tight junction; Crohn's disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, there has been a growing interest in harnessing the therapeutic potential of natural products and alternative medicine to combat inflammation—a pervasive factor in various health conditions. This Special Issue serves as a dedicated platform to explore and dissect the multifaceted aspects of the "Anti-Inflammatory Activity of Natural Products and Alternative Medicine: 2nd Edition"

Inflammation, while a vital aspect of the body's defense mechanism, can become chronic and contribute to the development and progression of numerous diseases, including atopic dermatitis, rhinitis, allergic conjunctivitis, asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease. The use of natural products and alternative medical approaches has garnered attention for their potential to mitigate inflammation and improve overall health outcomes.

This Special Issue brings together a diverse array of research articles, reviews, and studies that delve into the following key themes:

Natural compounds: unveiling the anti-inflammatory properties of natural compounds, ranging from botanical extracts and dietary constituents to minerals and herbal remedies.  

Pharmacological mechanisms: investigating the underlying molecular pathways and biological mechanisms through which natural products exert their anti-inflammatory effects.

We cordially invite you to publish research or review papers in this Special Issue, which aims to summarize the findings of recent studies on the bioactivity of natural and alternative medicines and the evolving landscape of the "Anti-Inflammatory Activity of Natural Products and Alternative Medicine: 2nd Edition."

Dr. Ju-Hye Yang
Dr. Kwang-Il Park
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • inflammatory diseases
  • environmental factors
  • atopic dermatitis
  • rhinitis
  • allergic conjunctivitis
  • asthma
  • inflammatory bowel disease

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Published Papers (1 paper)

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Research

14 pages, 6839 KiB  
Article
Anti-Inflammatory Effect of Chamaecyparis obtusa (Siebold & Zucc.) Endl. Leaf Essential Oil
by Sung-Hee Kim, Young-Ah Jang and Yong-Jin Kwon
Molecules 2024, 29(5), 1117; https://doi.org/10.3390/molecules29051117 - 01 Mar 2024
Viewed by 709
Abstract
Chamaecyparis obtusa (Siebold & Zucc.) Endl. (C. obtusa) belongs to the Cupressaceae family and is native to East Asian regions. Essential oils extracted from the leaves, bark, branches, and roots of C. obtusa have both aesthetic and medicinal properties and are [...] Read more.
Chamaecyparis obtusa (Siebold & Zucc.) Endl. (C. obtusa) belongs to the Cupressaceae family and is native to East Asian regions. Essential oils extracted from the leaves, bark, branches, and roots of C. obtusa have both aesthetic and medicinal properties and are thus widely used. However, detailed analyses of the active ingredients of C. obtusa extract are lacking. In this study, the sabinene content in the hydro-distillation of C. obtusa leaf essential oil (COD) was analyzed using GC-MS, and the anti-inflammatory effect of COD was compared with that of pure sabinene. Cell viability was evaluated by MTT assay, and nitric oxide (NO) production was measured using Griess reagent. Relative mRNA and protein levels were analyzed using RT-qPCR and western blot, and secreted cytokines were analyzed using a cytokine array kit. The results showed that both COD and sabinene inhibited the expression of inducible nitric oxide synthase (iNOS) and the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 in lipopolysaccharide (LPS)-induced RAW 264.7 cells. COD and sabinene also reduced the production of pro-inflammatory cytokines interleukin (IL)-1β, IL-6, IL-27, IL-1 receptor antagonist (IL-1ra), and granulocyte-macrophage colony-stimulating factor (GM-CSF). The anti-inflammatory mechanisms of COD and sabinene partially overlap, as COD was shown to inhibit MAPKs and the JAK/STAT axis, and sabinene inhibited MAPKs, thereby preventing LPS-induced macrophage activation. Full article
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