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Molecules
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New Approach in Multicomponent Reactions II
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New Approach in Multicomponent Reactions II

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 3220

Special Issue Editors

Dr. Ana Maria Gomez Neo

E-Mail Website
Guest Editor
Department of Organic and Inorganic Chemistry, Universidad de Extremadura, Badajoz, Spain
Interests: organic chemistry; synthetic organic chemistry; multicomponent reactions; heterocyclic chemistry; green chemistry; materials chemistry; bioorganic chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Carlos Fernández Marcos

E-Mail Website
Guest Editor
Department of Organic and Inorganic Chemistry, Universidad de Extremadura, Badajoz, Spain
Interests: synthetic methodology; multicomponent reactions; heterocyclic chemistry; bioactive molecules
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Multicomponent reactions are highly convergent processes that permit the synthesis of complex molecules in a simple procedure. This synthetic methodology has been widely used in different research fields, such as medicinal chemistry, combinatorial chemistry, green chemistry, or materials chemistry. In particular, multicomponent reactions are well suited for diversity-oriented chemistry, constituting an excellent tool for exploring chemical molecular space. Multicomponent chemistry is now more active than ever, and new approaches are being developed every day to respond to the challenges of contemporary organic chemistry.

Dr. Ana Maria Gomez Neo
Dr. Carlos Fernández Marcos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multicomponent reaction
  • MCR
  • new synthetic methodologies
  • isocyanides
  • green chemistry
  • diversity-oriented chemistry

Published Papers (2 papers)

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Research

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16 pages, 3891 KiB  
Article
Multicomponent Synthesis of 4-Aryl-4,9-dihydro-1H-pyrazolo[3,4-b]quinolines Using L-Proline as a Catalyst—Does It Really Proceed?
by Andrzej Danel, Elżbieta Porębska, Kacper Markiel, Oleksii Havrysh, Mateusz Kucharek, Arkadiusz Gut and Tomasz Uchacz
Molecules 2023, 28(22), 7612; https://doi.org/10.3390/molecules28227612 - 15 Nov 2023
Viewed by 788
Abstract
Looking for effective synthetic methods for 1H-pyrazolo[3,4-b]quinolines preparation, we came across a procedure where, in a three-component reaction catalysed by L-proline, 4-aryl-4,9-dihydro-1H-pyrazolo[3,4-b]quinolines are formed. These compounds can be easily oxidised to a fully aromatic system, [...] Read more.
Looking for effective synthetic methods for 1H-pyrazolo[3,4-b]quinolines preparation, we came across a procedure where, in a three-component reaction catalysed by L-proline, 4-aryl-4,9-dihydro-1H-pyrazolo[3,4-b]quinolines are formed. These compounds can be easily oxidised to a fully aromatic system, which gives hope for a synthetic method that could replace, e.g., Friedländer condensation, often used for this purpose, even though severely limited by the availability of suitable substrates. However, after careful repetition of the procedures described in the publication, it turned out that the compounds described therein do not form at all. The actual compounds turned out to be 4,4-(phenyl-methylene)-bis-(3-methyl-1-phenylpyrazol-5-oles). Therefore, 4-Aryl-4,9-dihydro-1H-pyrazolo[3,4-b]quinolines were prepared by another method and used as standards to compare the products formed in the original procedure. Full article
(This article belongs to the Special Issue New Approach in Multicomponent Reactions II)
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Review

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43 pages, 18066 KiB  
Review
The Castagnoli–Cushman Reaction
by José Luis Ramiro, Sonia Martínez-Caballero, Ana G. Neo, Jesús Díaz and Carlos F. Marcos
Molecules 2023, 28(6), 2654; https://doi.org/10.3390/molecules28062654 - 15 Mar 2023
Cited by 3 | Viewed by 2176
Abstract
Since the first reports of the reaction of imines and cyclic anhydrides by Castagnoli and Cushman, this procedure has been applied to the synthesis of a variety of lactams, some of them with important synthetic or biological interest. The scope of the reaction [...] Read more.
Since the first reports of the reaction of imines and cyclic anhydrides by Castagnoli and Cushman, this procedure has been applied to the synthesis of a variety of lactams, some of them with important synthetic or biological interest. The scope of the reaction has been extended to the use of various Schiff bases and anhydrides as well as to different types of precursors for these reagents. In recent years, important advances have been made in understanding the mechanism of the reaction, which has historically been quite controversial. This has helped to develop reaction conditions that lead to pure diastereomers and even homochiral products. In addition, these mechanistic studies have also led to the development of new multicomponent versions of the Castagnoli–Cushman reaction that allow products with more diverse and complex molecular structures to be easily obtained. Full article
(This article belongs to the Special Issue New Approach in Multicomponent Reactions II)
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