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Isolation, Identification and Application of Biologically Active Natural Products—Second Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 757

Special Issue Editors


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Guest Editor
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, China
Interests: medicinal and edible plants; natural product bioactivity; phytochemistry; structural characterization; biological activity evaluation; toxicological evaluation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, China
Interests: plant-based foods; functional foods; medicinal and edible plants; natural product bioactivity; phytochemistry; structural characterization; biological activity evaluation; toxicological evaluation

Special Issue Information

Dear Colleagues,

It is well known that natural products are small molecules produced naturally by any organism including primary and secondary metabolites. They are usually presented in the edible and medicinal plants, animals and microorganism. Traditionally, ethnopharmacology and phytomedicine have been proved to be an invaluable source of information on the probable medicinal properties of these natural resources. To date, the numerous phytochemical and pharmacological studies have been conducted to found significant biological ingredients. And some of these bioactive compounds were developed into clinical drugs. In many cases, current studies conducted in various pharmacological models (in vitro, in vivo, clinical trials) played important roles in biological evaluation of natural products being used as potential medicinal agents.

This Special Issue of Molecules cover the aspects concerning extraction, isolation and structure elucidation of natural products, structure-bioactivity relationship of natural products, novel analytical methods including in natural products, bioaccessibility and bioavailability of natural products, biological evaluation of bioactive natural products; safety and efficacy phytotherapy of natural products. I hope that this Special Issue will increase the understanding of bioactive natural products and I would like to thank the authors for their valuable contributions.

Prof. Dr. Gui-Guang Cheng
Dr. Ya-Ping Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemistry
  • natural product chemistry
  • food chemistry
  • secondary metabolites
  • isolation and structure elucidation of bioactive compounds
  • novel analytical technique in natural products
  • phytomedicine
  • biological and pharmacological activity
  • toxicological evaluation

Related Special Issue

Published Papers (1 paper)

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Research

20 pages, 10149 KiB  
Article
Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway
by Yongchao Wang, Yongpeng Wang, Tianrui Zhao, Mengcheng Li, Yudan Wang, Jianxin Cao, Yaping Liu, Zhengxuan Wang and Guiguang Cheng
Molecules 2024, 29(6), 1384; https://doi.org/10.3390/molecules29061384 - 20 Mar 2024
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Abstract
Que Zui tea (QT) is an important herbal tea in the diet of the ‘Yi’ people, an ethnic group in China, and it has shown significant antioxidant, anti-inflammatory, and hepatoprotective effects in vitro. This study aims to explore the protective effects of the [...] Read more.
Que Zui tea (QT) is an important herbal tea in the diet of the ‘Yi’ people, an ethnic group in China, and it has shown significant antioxidant, anti-inflammatory, and hepatoprotective effects in vitro. This study aims to explore the protective effects of the aqueous-ethanol extract (QE) taken from QT against ᴅ-galactose (ᴅ-gal)-induced oxidative stress damage in mice and its potential mechanisms. QE was identified as UHPLC-HRMS/MS for its chemical composition and possible bioactive substances. Thus, QE is rich in phenolic and flavonoid compounds. Twelve compounds were identified, the main components of which were chlorogenic acid, quinic acid, and 6′-O-caffeoylarbutin. Histopathological and biochemical analysis revealed that QE significantly alleviated brain, liver, and kidney damage in ᴅ-gal-treated mice. Moreover, QE remarkably attenuated oxidative stress by activating the Nrf2/HO-1 pathway to increase the expression of antioxidant indexes, including GSH, GSH-Px, CAT, SOD, and T-AOC. In addition, QE administration could inhibit the IL-1β and IL-6 levels, which suppress the inflammatory response. QE could noticeably alleviate apoptosis by inhibiting the expressions of Caspase-3 and Bax proteins in the brains, livers, and kidneys of mice. The anti-apoptosis mechanism may be related to the upregulation of the SIRT1 protein and the downregulation of the p53 protein induced by QE in the brain, liver, and kidney tissues of mice. Molecular docking analysis demonstrated that the main components of QE, 6′-O-caffeoylarbutin, chlorogenic acid, quinic acid, and robustaside A, had good binding ability with Nrf2 and SIRT1 proteins. The present study indicated that QE could alleviate ᴅ-gal-induced brain, liver and kidney damage in mice by inhibiting the oxidative stress and cell apoptosis; additionally, the potential mechanism may be associated with the SIRT1/Nrf2 signaling pathway. Full article
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