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Exclusive Papers Collection of Editorial Board Members and Invited Scholars on Food Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 924

Special Issue Editors


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Guest Editor
Agrarian Technological Institute of Castilla and Leon (ITACyL), Finca Zamadueñas, 47071 Valladolid, Spain
Interests: functional food; ingredients; bioactivity; antioxidants; food and health
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Agrarian Technological Institute of Castilla and Leon (ITACyL), Finca Zamadueñas, 47071 Valladolid, Spain
Interests: food processing; antioxidants; postharvest; cereals and pulses; fruit and vegetables; extrusion; edible coatings; high pressure processing; vacuum frying
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to announce this Special Issue, which will be a collection of high-quality papers on food chemistry from invited scholars and the Editorial Board Members. Our aim is to provide a platform for sharing insights and developments in the field of food chemistry research, and a venue for networking and communication between scholars.

We will accept submissions of original research articles and comprehensive review papers, grounded in sound science, that addresses the current critical issues in this field and highlights novel concepts.

Please note that all papers will undergo a thorough peer-review process, and if successful, will be published in a fully open-access mode.

Dr. Ana Belén Martín Diana
Dr. Daniel Rico
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional food
  • ingredients
  • bioactivity
  • antioxidants
  • food and health
  • food processing

Published Papers (1 paper)

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Research

15 pages, 1270 KiB  
Article
Hydroxylated Tetramethoxyflavone Affects Intestinal Cell Permeability and Inhibits Cytochrome P450 Enzymes
by Kuo-Ching Jan and Mohsen Gavahian
Molecules 2024, 29(2), 322; https://doi.org/10.3390/molecules29020322 - 09 Jan 2024
Viewed by 753
Abstract
Tetramethoxyflavones (TMFs) found in the Citrus genus have garnered considerable interest from food scientists and the health food industry because of their promising biological properties. Nonetheless, there are currently limited data available regarding the effectiveness and bioavailability of “hydroxylated TMFs”, which are flavones [...] Read more.
Tetramethoxyflavones (TMFs) found in the Citrus genus have garnered considerable interest from food scientists and the health food industry because of their promising biological properties. Nonetheless, there are currently limited data available regarding the effectiveness and bioavailability of “hydroxylated TMFs”, which are flavones known for their potential in disease prevention through dietary means. This study aims to provide insights into the chemical and biological properties of hydroxylated TMF and evaluates its effects on intestinal cell permeability and cytochrome P450 (CYP) inhibition. Liquid chromatography–mass spectrometry (LC-MS) and microsomes analyze the TMFs and hydroxylated TMFs, elucidating cell penetration and metabolic inhibition potential. 3H7-TMF shows the fastest (1-h) transport efficiency in intestinal cells. The Caco-2 cell model exhibits significant transport and absorption efficiency. Dissolved hydroxyl-TMF with hydrophilicity possibly permeates the gut. 3H7-TMF has higher transport efficiency (46%) 3H6-TMF (39%). IC50 values of TMFs (78-TMF, 57-TMF, 3H7-TMF, 3H6-TMF) against CYP enzymes (CYP1A2, CYP2D6, CYP2C9, CYP2C19, CYP3A4) range from 0.15 to 108 μM, indicating potent inhibition. Hydroxyl groups enhance TMF hydrophilicity and membrane permeability. TMFs display varied inhibitory effects due to hydroxyl and methoxy hindrance. This study underscores the strong CYP inhibitory capabilities in these TMFs, implying potential food–drug interactions if used in medicines or supplements. These findings can also help with food nutrition improvement and pharma food developments through innovative approaches for Citrus waste valorization. Full article
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