Novel Natural and Derivative Products: Synthesis and Pharmacological Potential II
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 1645
Special Issue Editors
Interests: biological activity; organic and medicinal chemistry; pharmacology; neurodegenerative disorders
Special Issues, Collections and Topics in MDPI journals
Interests: stereodynamic behavior; dynamic stereochemistry; NMR investigation; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nature contains many compounds with biologically active properties, and scientists have created many ways to improve upon them. This Issue is devoted to the identification of derivatives of natural substances using modern technologies, as well as their modification by the inclusion functional groups in their structures to achieve specific physicochemical properties and biological activities.
Neurological disorders are one of the main sources of premature mortality, ranking second after cardiovascular diseases, and have become the absolute leaders in terms of the percentage of temporary or permanent disability among survivors. As the prevalence of most neurological disorders increases with age, this burden is expected to increase in countries with aging populations, despite the significant progress that has been made in stroke prevention. During the 2020 pandemic, the defeat of the central nervous system also began to play an important role in the clinical picture and severity of COVID-19 infection. Degenerative changes in the cerebral cortex of convalescents have been described to persist for more than 5 months and have serious cognitive consequences, as well as concomitant depressive states, against the background of inflammatory processes.
The epidemiology of infection predicts that there wll be an increased demand for therapeutic approaches to treat both elderly patients and the younger working population.
In this Issue, particular attention will be paid to bioactive compounds for the treatment of neurodegenerative diseases and the development of new antiviral and anti-inflammatory drugs. The compounds obtained from natural sources and synthesized under laboratory conditions will be considered in the context of in silico technologies’ application, along with in vitro and in vivo experiments. The results should include modern methods of physicochemical analysis, such as IR, UV, multinuclear NMR, HPLC, GC-MS, computer approaches of studying the structure–biological activity relationship, and biological methods confirming their activity in in vitro and in vivo models.
Thus, the relevance of this Special Issue, dedicated to the identification, synthesis, prediction, and verification of the pharmacological activity of natural and semi-synthetic compounds, is beyond doubt. In this regard, I would be glad if you agreed to submit an original research paper, short message, or overview to this Issue.
Prof. Dr. Yuri Baukov
Dr. Vadim V. Negrebetsky
Guest Editors
Manuscript Submission Information
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Keywords
- natural compounds and their synthetic derivatives
- medicinal chemistry
- structure–activity relationships
- inflammatory processes
- neurodegenerative disorders
- viral infections
- cognitive impairment
- antimicrobial agents
- pharmaco-toxicological activities
