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Natural Product Chemistry in China-2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1387

Special Issue Editors


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Guest Editor
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Interests: high throughput screening of bioactive compounds from natural products
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
Interests: synthesis and structural modification of natural products for the discovery of lead compound; small-molecule probe synthesis employing PROTACs technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nature is an underexplored source of unique and desirable structural scaffolds for novel drug discovery. Natural products and natural product structures continue to play a highly significant role in the drug discovery and development process. Nature-derived molecules afford varied scaffolds for bioassay and structure modification. The bio-guided isolation, semi-synthesis, and total synthesis of natural bioactive compounds has gained increased research attention in the cross field of 

organic chemistry and natural products. Therefore, this Special Issue aims to illustrate the most recent and important developments in the isolation, modification, and bioactivities of natural compounds from medicinal plants, traditional Chinese medicine, and marine sources. Special attention will be paid to effective solutions that optimize natural product scaffolds based on structure−activity relationships (SARs) and novel phenotypic bioassays. The identification of active compounds with similar pharmacological effects or targets by analytical approaches coupled with advanced bioassays will also be highlighted.

Communications, full papers, and reviews on the abovementioned topics are particularly welcome.

Prof. Dr. Yi Wang
Prof. Dr. Xingxian Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds isolated from traditional Chinese medicine
  • structure elucidation of bioactive compounds
  • bioinspired drug design
  • total synthesis of natural products
  • structural optimization of natural products
  • C-H activation in the modification of bioactive compounds
  • structure–activity relationship of natural compounds

Published Papers (1 paper)

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Research

13 pages, 3021 KiB  
Article
Synthesis of Aminoalkyl Sclareolide Derivatives and Antifungal Activity Studies
by Ziyi Li, Hua Gao, Haibo Mei, Guangwei Wu, Vadim A. Soloshonok and Jianlin Han
Molecules 2023, 28(10), 4067; https://doi.org/10.3390/molecules28104067 - 12 May 2023
Viewed by 1008
Abstract
Sclareolide was developed as an efficient C-nucleophilic reagent for an asymmetric Mannich addition reaction with a series of N-tert-butylsulfinyl aldimines. The Mannich reaction was carried out under mild conditions, affording the corresponding aminoalkyl sclareolide derivatives with up to 98% [...] Read more.
Sclareolide was developed as an efficient C-nucleophilic reagent for an asymmetric Mannich addition reaction with a series of N-tert-butylsulfinyl aldimines. The Mannich reaction was carried out under mild conditions, affording the corresponding aminoalkyl sclareolide derivatives with up to 98% yield and 98:2:0:0 diastereoselectivity. Furthermore, the reaction could be performed on a gram scale without any reduction in yield and diastereoselectivity. Additionally, deprotection of the obtained Mannich addition products to give the target sclareolide derivatives bearing a free N-H group was demonstrated. In addition, target compounds 46 were subjected to an antifungal assay in vitro, which showed considerable antifungal activity against forest pathogenic fungi. Full article
(This article belongs to the Special Issue Natural Product Chemistry in China-2nd Edition)
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