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Novel Nanocomposite and Metal-Organic Framework Hybrid for the Biomedical and Environmental Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2073

Special Issue Editors


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Guest Editor
Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603 203, Tamilnadu, India
Interests: enzyme immobilization; bioenergy; environmental application; nanomaterials; novel framework; microbial technology

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Guest Editor
Department of Materials Science and Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA
Interests: enzyme immobilization; water treatment; environmental remediation; material science; novel framework; microbiology

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Guest Editor
Department of Civil and Environmental Engineering, Politecnico Di Milano, Piazza Leonardo da Vinci, 32, 20133 Milano MI, Italy
Interests: enzyme immobilization; environmental application; nanomaterials; novel framework; water treatment
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Special Issue Information

Dear Colleagues,

Metal-organic frameworks are one of the trending research areas in biomedical-research-based applications that are thriving through a common key known as enzymes. The combination of nanocomposites with metal-organic frameworks will open up paths for novel research that can make use of enzymes and enzyme immobilization for various applications, including therapeutics, pharmaceuticals, biosensing, targeted drug delivery, drug discovery, bioimaging, theranostics, and the screening and detection of various disease conditions.

Their unique features, stability, specificity, tunability, and manipulative nature makes nanocomposite–metal organic framework hybrids an advanced technology in the field of medical research, medical industries, and wastewater treatment. This issue focuses on novel nanocomposite–MOF hybrid materials, their characterization, catalytic studies, efficiency studies, along with various biomedical industries, the wastewater treatment sector, and research-based applications, including enzyme immobilization, doping, and multi-stimuli responsive nature.

This Special Issue aims to attract researchers actively working in the development of nanomaterials and their application in the biomedical area of biotechnology and environmental applications (e.g., wastewater treatment). We cordially invite researchers to contribute their original research work and review based on the theme areas.

Dr. Ethiraj Selvarajan
Dr. Melvin S. Samuel
Dr. Srikanth Vuppala
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanocomposite – MOF hybrid
  • Microbial enzyme
  • Biosensing
  • Biomedical devices
  • Enzyme immobilization
  • Industrial application
  • Target drug delivery system
  • Detection and imaging
  • Theranoustics
  • Wastewater

Published Papers (1 paper)

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Research

14 pages, 2001 KiB  
Article
Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters
by Li-Guo Liao, Duo Ke, Guo-Chen Li, Sheng Zhang and Bang-Jing Li
Molecules 2023, 28(2), 852; https://doi.org/10.3390/molecules28020852 - 14 Jan 2023
Cited by 3 | Viewed by 1753
Abstract
The important role of gasotransmitters in physiology and pathophysiology suggest employing gasotransmitters for biomedical treatment. Unfortunately, the difficulty in storage and controlled delivery of these gaseous molecules hindered the development of effective gasotransmitters-based therapies. The design of a safe, facile, and wide-scale method [...] Read more.
The important role of gasotransmitters in physiology and pathophysiology suggest employing gasotransmitters for biomedical treatment. Unfortunately, the difficulty in storage and controlled delivery of these gaseous molecules hindered the development of effective gasotransmitters-based therapies. The design of a safe, facile, and wide-scale method to delivery multiple gasotransmitters is a great challenge. Herein, we use an ultrasonic assisted preparation γ-cyclodextrin metal organic framework (γ-CD-MOF) as a broad-spectrum delivery vehicle for various gasotransmitters, such as SO2, NO, and H2S. The release rate of gasotransmitters could be tuned by modifying the γ-CD-MOF with different Pluronics. The biological relevance of the exogenous gasotransmitters produced by this method is evidenced by the DNA cleavage ability and the anti-inflammatory effects. Furthermore, the γ-CD-MOF composed of food-grade γ-CD and nontoxic metal salts shows good biocompatibility and particle size (180 nm). Therefore, γ-CD-MOF is expected to be an excellent tool for the study of co-delivery and cooperative therapy of gasotransmitters. Full article
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