Importance of Flow Chemistry: Active Pharmaceutical Production
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1820
Special Issue Editors
Interests: flow chemistry; organic synthesis; total synthesis; cycloadditions; heterocyclics; carbohydrates; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: synthetic organic chemistry; synthetic medicinal chemistry; synthetic methodology; multi-component reactions; heterogeneous catalysis; green chemistry
Interests: physical organic chemistry; computational chemistry; cycloadditions; photocatalysis; electrocatalysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Flow chemistry (FC) is one of the rapidly growing fields in modern research. Owing to its advantages over conventional batch techniques, such as faster heat and mass transfer, accurate control over a reaction’s temperature, and a laminar flow profile, the importance if FC has been studied extensively. FC is carried out in continuous-flow reactors which comprise tubes with micro/millimeter-range diameters. These tubes offer a higher order of surface-to-volume ratio when compared to conventional batch reactors. Further, flow techniques do not demand large quantities of reagents and solvents or harsh reaction conditions, in contrast to batch techniques. In addition, flow techniques offer an unprecedented way to observe the reaction progress by tuning parameters like flow rate, temperature, pressure etc. These features are very useful to obtain large yields in highly selective reactions. The development of FC leads to the advancement of green chemistry, as it emphasizes the prevention of waste formation rather than handling or eliminating it. Features such as pressure regulation and control over residence time further broaden the versatility of flow techniques. FC techniques also warrant the safe handling of gaseous and dangerous chemicals, which found widespread applications of FC for multistep reactions in industrial drug synthesis.
In recent years, novel methodologies have been developed in continuous flow chemistry. Some of these techniques include gas-permeable tubing, multi-jet oscillating disk reactors, electrochemical microreactors, coupling of ultrasound generators with microreactors etc. These new methodologies/techniques open new avenues in the field of FC to overcome the limitations of batch techniques and explore more synthetic chemistry using flow techniques.
The current Special Issue addresses the rapid advances in flow chemistry and continuous-flow techniques to improve the public understanding and create a one-place knowledge bank of flow chemistry. The diverse state-of-the-art of flow methodologies in chemistry and the scope for their future developments are the main agenda of this Special Issue.
We welcome original research, review, mini review and perspective articles on themes including, but not limited to, synthesis through homogeneous or heterogeneous flow chemistry; chemoenzymatic approaches; photochemistry or electrochemistry flow, micro- and mesoreactors; photochemical reactions under continuous-flow conditions; catalytic and enzymatic transformations; and the development of in-flow reactions in alternative solvents (ionic liquids and deep eutectic solvents. Special attention will be given to the synthesis of chiral molecules, building blocks, or intermediates for the preparation of industrial products, active pharmaceutical ingredients, and biologically active compounds.
Dr. Lalitha Gummidi
Dr. Nagaraju Kerru
Dr. Venkata Surya Kumar Choutipalli
Guest Editors
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Keywords
- flow reactors
- catalytic reactors
- enzymatic reactions
- deep eutectic solvents
- photochemistry
- microreactors
- asymmetric synthesis
- synergistic catalysis
- organocatalysis
- photocatalysis
- synthesis of heterocycles
