Role of Natural and Synthetic Compounds in Inflammation and Inflammatory-Related Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 3971
Special Issue Editor
Interests: inflammation; immuno-pharmacology; pharmacology of natural compounds and nutraceuticals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Inflammatory injuries induce the release of a variety of systemic mediators, cytokines, and chemokines that orchestrate the cellular infiltration that consequentially brings about the resolution of inflammatory responses and the restoration of tissue integrity. However, persistent inflammatory stimuli or the disregulation of mechanisms of the resolution phase can lead to chronic inflammation and inflammatory-based diseases.
Nowadays, commercially approved anti-inflammatory drugs are represented by nonsteroidal anti-inflammatory drugs (NSAID); glucocorticoids (SAID); and, in some cases, immunosuppressant and/or biological drugs. These agents are effective for the relief of the main inflammatory symptoms. However, they induce severe side effects, and most of them are inadequate for chronic use.
Starting from these premises, the demand for new effective and safe anti-inflammatory drugs has furthered research into new therapeutic approaches. The recent and emerging scientific community approach is oriented towards natural products/compounds that could aid the discovery of new active molecules and the development of new drugs and potentially useful therapeutic agents in different inflammatory-related diseases.
We hope that this Special Issue will stimulate the interest of the scientific community involved in studying the effects of natural and synthetic compounds in different fields of interests such as acute and chronic inflammation, inflammatory pain, inflammatory-related diseases (such as autoimmune diseases), and others.
The papers published here will contribute to proposing new insights into the mechanisms of several conditions, as well as suggesting new diagnostic alternatives and therapeutic targets in widespread pathologies.
Prof. Francesco Maione
Guest Editor
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Keywords
- Inflammation
- Inflammatory-based diseases
- Immunity
- Natural compounds
- Nutraceuticals
