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Total Synthesis of Natural Product 2021

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (15 July 2021) | Viewed by 2719

Special Issue Editor


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Guest Editor
Department of Chemistry and Materials Science, Aalto University School of Chemical Engineering, Kemistintie 1, P.O. Box 16100, 02150 Espoo, Finland
Interests: organic synthesis; asymmetric synthesis; natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the course of evolution, Nature has developed an inexhaustible diversity of biologically active natural products. The great diversity of natural products lends challenge to their synthesis, encouraging the development of new synthetic methodology. Total synthesis plays an important role as a means to achieve the unambiguous assignment of chemical structure and obtain sufficient material for biological assessment and consequent applications. In this forthcoming Special Issue of Molecules entitled “Total Synthesis of Natural Products”, we invite contributions on the total synthesis of natural products, including recent key findings, latest developments, and innovative synthetic approaches.

As Guest Editor, I cordially invite researchers to submit their recent advances in the field to this Special Issue of Molecules.

Prof. Dr. Ari Koskinen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Natural products
  • Total synthesis

Published Papers (1 paper)

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Research

14 pages, 1710 KiB  
Article
The Synthesis of 3-(R)- and 3-(S)-Hydroxyeicosapentaenoic Acid
by Gard Gjessing, Lars-Inge Gammelsæter Johnsen, Simen Gjelseth Antonsen, Jens M. J. Nolsøe, Yngve Stenstrøm and Trond Vidar Hansen
Molecules 2022, 27(7), 2295; https://doi.org/10.3390/molecules27072295 - 1 Apr 2022
Viewed by 2205
Abstract
Monohydroxylated polyunsaturated fatty acids belonging to the oxylipin class of natural products are present in marine and terrestrial sources as well as in the human body. Due to their biological activities and role in diverse biosynthetic pathways, oxylipins biosynthesized from eicosapentaenoic acid and [...] Read more.
Monohydroxylated polyunsaturated fatty acids belonging to the oxylipin class of natural products are present in marine and terrestrial sources as well as in the human body. Due to their biological activities and role in diverse biosynthetic pathways, oxylipins biosynthesized from eicosapentaenoic acid and arachidonic acid have attracted great interest from the scientific community. One example is 3-hydroxyeicosapentaenoic acid where the absolute configuration at C-3 has only been tentatively assigned. In this paper, studies on acetate type aldol reactions that enabled the preparation of 3-(R)-hydroxyeicosapentaenoic acid (3R-HETE, 2) and its enantiomer are presented. Full article
(This article belongs to the Special Issue Total Synthesis of Natural Product 2021)
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