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Carriers, Channels, Receptors, and Enzymes: Protein Targets of New Synthetic and Natural Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 301

Special Issue Editors

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Guest Editor
Department of Biosciences, Biotechnologies and Enviroment, NIBA University of Bari “Aldo Moro”, Via E. Orabona, 4, 70125 Bari, Italy
Interests: mitochondrial carrier; a-glucosidase inhibitors; AChE inhibitors; neurotoxicity; butyrylcholinesterase inhibitors

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Guest Editor
ENEA, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Department of Sustainability, Trisaia Research Center, 75026 Rotondella, Italy
Interests: mitochondria; protein purification; antioxidant activity; biomolecules extraction; agricultural waste valorization; novel food
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmacy - Pharmaceutical Sciences, UNIBA University of Bari “Aldo Moro”, Via E. Orabona, 4, 70125 Bari, Italy
Interests: medicinal chemistry; drug design; chirality; cancer; metabolic disorders; antibacterials; ion channels; rare diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Proteins are biomolecules playing a key role in biochemical and physiological processes, especially as carriers, channels, receptors and enzymes. There are also various links between the malfunction or even absence of any of these functions and several human diseases, including diabetes, metabolic syndrome, cardiovascular and neurodegenerative diseases, infectious diseases, and cancer. Therefore, scientific research is committed to designing and synthesizing or extracting from natural sources new bioactive compounds that have protein biomolecules as pharmacological targets to develop innovative treatments of human pathologies. This Special Issue aims to collect and publish original research articles and reviews on the design, synthesis, and development of new bioactive molecules or on natural compounds as drug candidates targeting carriers, channels, receptors, and enzymes.

In particular, we invite scientists focused on organic chemistry, medicinal chemistry, food chemistry, chemical biology, and biotechnology to report studies of synthetic and natural compounds ranging from the design and synthesis to their pharmacological evaluation in vivo or in vitro and computational modeling.

We very much look forward to your contributions.

Dr. Annalisa De Palma
Dr. Anna Spagnoletta
Prof. Dr. Giovanni Lentini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • carrier
  • channel
  • receptor
  • enzyme
  • drug design
  • synthesis
  • biological evaluation
  • inhibitors
  • bioactive compounds
  • cell metabolism
  • mitochondria
  • human pathology

Published Papers

This special issue is now open for submission.
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